Apoptosis-induced chromosome break in the AF9 gene
Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. Th...
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| Format: | Thesis |
| Language: | English |
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Please get the password from Digital Collection Development Unit, ext : 3932 / 3914
2008
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| Online Access: | http://ir.unimas.my/id/eprint/14116/ http://ir.unimas.my/id/eprint/14116/2/Cynthia%20Patricia%20ft.pdf |
| _version_ | 1848837571126231040 |
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| author | Cynthia Patricia, anak Nicholas |
| author_facet | Cynthia Patricia, anak Nicholas |
| author_sort | Cynthia Patricia, anak Nicholas |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. There are evidences that the apoptotic nuclease may play a role in chromosomal translocation as they are known to cleave the chromosome. Erroneous repair of these chromosomal breaks by DNA repair mechanisms may mediate chromosomal translocations. One of the genes frequently involved in chromosomal translocations in acute leukaemia is the AF9 gene. The AF9 gene is only one of the fusion partners of the MLL gene, thus the same hypothesis can be tested on other MLL fusion partner genes. It is possible that apoptosis may also play a role during chromosomal breakage in other MLL fusion partner genes too. |
| first_indexed | 2025-11-15T06:41:46Z |
| format | Thesis |
| id | unimas-14116 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:41:46Z |
| publishDate | 2008 |
| publisher | Please get the password from Digital Collection Development Unit, ext : 3932 / 3914 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-141162025-06-18T03:38:16Z http://ir.unimas.my/id/eprint/14116/ Apoptosis-induced chromosome break in the AF9 gene Cynthia Patricia, anak Nicholas RB Pathology Chromosomal translocations are commonly associated with leukemia. Although the results of translocation are shown to be leukaemogenic, the initial event leading to the translocation remains mainly unknown. However, it is know that the initial step of translocation is the chromosome break event. There are evidences that the apoptotic nuclease may play a role in chromosomal translocation as they are known to cleave the chromosome. Erroneous repair of these chromosomal breaks by DNA repair mechanisms may mediate chromosomal translocations. One of the genes frequently involved in chromosomal translocations in acute leukaemia is the AF9 gene. The AF9 gene is only one of the fusion partners of the MLL gene, thus the same hypothesis can be tested on other MLL fusion partner genes. It is possible that apoptosis may also play a role during chromosomal breakage in other MLL fusion partner genes too. Please get the password from Digital Collection Development Unit, ext : 3932 / 3914 2008 Thesis NonPeerReviewed text en http://ir.unimas.my/id/eprint/14116/2/Cynthia%20Patricia%20ft.pdf Cynthia Patricia, anak Nicholas (2008) Apoptosis-induced chromosome break in the AF9 gene. Masters thesis, Universiti Malaysia Sarawak, (UNIMAS). |
| spellingShingle | RB Pathology Cynthia Patricia, anak Nicholas Apoptosis-induced chromosome break in the AF9 gene |
| title | Apoptosis-induced chromosome break in the AF9 gene |
| title_full | Apoptosis-induced chromosome break in the AF9 gene |
| title_fullStr | Apoptosis-induced chromosome break in the AF9 gene |
| title_full_unstemmed | Apoptosis-induced chromosome break in the AF9 gene |
| title_short | Apoptosis-induced chromosome break in the AF9 gene |
| title_sort | apoptosis-induced chromosome break in the af9 gene |
| topic | RB Pathology |
| url | http://ir.unimas.my/id/eprint/14116/ http://ir.unimas.my/id/eprint/14116/2/Cynthia%20Patricia%20ft.pdf |