Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis
Aim To systematically review the literature to compare the use of DPP4 inhibitors vs sulphonylurea in type 2 diabetic Muslim patients who fast in Ramadan, with regards to its safety, tolerability, glycemic control, and body weight changes. Methods All English-language medical literature published fr...
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2016
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| Online Access: | http://ir.unimas.my/id/eprint/13598/ http://ir.unimas.my/id/eprint/13598/7/Comparative%20studies%20of%20dipeptidyl%20peptidase%20%28abstract%29.pdf |
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| author | Loh, Huai Heng Yee, Anne Loh, Huai Seng Norlela, Sukor Nor Azmi Zmi, Kamaruddin |
| author_facet | Loh, Huai Heng Yee, Anne Loh, Huai Seng Norlela, Sukor Nor Azmi Zmi, Kamaruddin |
| author_sort | Loh, Huai Heng |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Aim To systematically review the literature to compare the use of DPP4 inhibitors vs sulphonylurea in type 2 diabetic Muslim patients who fast in Ramadan, with regards to its safety, tolerability, glycemic control, and body weight changes. Methods All English-language medical literature published from inception till October 2014 which met the inclusion criteria were reviewed and analyzed. Results A total of nine papers were included, reviewed and analyzed. The total sample size was 4276 patients. All studies used either of the two DPP4 inhibitors - Vildagliptin or Sitagliptin, vs sulphonylurea or meglitinides. Patients receiving DPP4 inhibitors were less likely to develop symptomatic hypoglycemia (risk ratio 0.46; 95% CI, 0.30-0.70), confirmed hypoglycemia (risk ratio 0.36; 95% CI, 0.21-0.64) and severe hypoglycemia (risk ratio 0.22; 95% CI, 0.10-0.53) compared with patients on sulphonylureas. There was no statistically significant difference in HbA1C changes comparing Vildagliptin and sulphonylurea. Conclusion DPP4 inhibitor is a safer alternative to sulphonylurea in Muslim patients with type 2 diabetes mellitus who fast during the month of Ramadan as it is associated with lower risk of symptomatic, confirmed and severe hypoglycemia, with efficacy comparable to sulphonylurea. |
| first_indexed | 2025-11-15T06:39:42Z |
| format | Article |
| id | unimas-13598 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:39:42Z |
| publishDate | 2016 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-135982017-02-17T01:17:55Z http://ir.unimas.my/id/eprint/13598/ Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis Loh, Huai Heng Yee, Anne Loh, Huai Seng Norlela, Sukor Nor Azmi Zmi, Kamaruddin R Medicine (General) Aim To systematically review the literature to compare the use of DPP4 inhibitors vs sulphonylurea in type 2 diabetic Muslim patients who fast in Ramadan, with regards to its safety, tolerability, glycemic control, and body weight changes. Methods All English-language medical literature published from inception till October 2014 which met the inclusion criteria were reviewed and analyzed. Results A total of nine papers were included, reviewed and analyzed. The total sample size was 4276 patients. All studies used either of the two DPP4 inhibitors - Vildagliptin or Sitagliptin, vs sulphonylurea or meglitinides. Patients receiving DPP4 inhibitors were less likely to develop symptomatic hypoglycemia (risk ratio 0.46; 95% CI, 0.30-0.70), confirmed hypoglycemia (risk ratio 0.36; 95% CI, 0.21-0.64) and severe hypoglycemia (risk ratio 0.22; 95% CI, 0.10-0.53) compared with patients on sulphonylureas. There was no statistically significant difference in HbA1C changes comparing Vildagliptin and sulphonylurea. Conclusion DPP4 inhibitor is a safer alternative to sulphonylurea in Muslim patients with type 2 diabetes mellitus who fast during the month of Ramadan as it is associated with lower risk of symptomatic, confirmed and severe hypoglycemia, with efficacy comparable to sulphonylurea. Elsevier Ltd 2016-06-01 Article PeerReviewed text en http://ir.unimas.my/id/eprint/13598/7/Comparative%20studies%20of%20dipeptidyl%20peptidase%20%28abstract%29.pdf Loh, Huai Heng and Yee, Anne and Loh, Huai Seng and Norlela, Sukor and Nor Azmi Zmi, Kamaruddin (2016) Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis. Primary Care Diabetes, 10 (3). pp. 210-219. ISSN 17519918 https://www.scopus.com/record/display.uri?eid=2-s2.0-84942044944&origin=resultslist&sort=plf-f&src=s&st1=Comparative+studies+of+dipeptidyl+peptidase+4+inhibitor+vs+sulphonylurea+among+Muslim+Type+2+diabetes+patients+who+fast+in+the+month+of+Ramadan%3a+A+s DOI: 10.1016/j.pcd.2015.09.001 |
| spellingShingle | R Medicine (General) Loh, Huai Heng Yee, Anne Loh, Huai Seng Norlela, Sukor Nor Azmi Zmi, Kamaruddin Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title | Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title_full | Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title_fullStr | Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title_full_unstemmed | Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title_short | Comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among Muslim Type 2 diabetes patients who fast in the month of Ramadan: A systematic review and meta-analysis |
| title_sort | comparative studies of dipeptidyl peptidase 4 inhibitor vs sulphonylurea among muslim type 2 diabetes patients who fast in the month of ramadan: a systematic review and meta-analysis |
| topic | R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/13598/ http://ir.unimas.my/id/eprint/13598/ http://ir.unimas.my/id/eprint/13598/ http://ir.unimas.my/id/eprint/13598/7/Comparative%20studies%20of%20dipeptidyl%20peptidase%20%28abstract%29.pdf |