Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents
A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR, 1H and 13C NMR spectroscopy. Antibacterial activities against wild-type Escherichi...
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| Format: | Article |
| Language: | English |
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Taylor and Francis Ltd.
2016
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| Online Access: | http://ir.unimas.my/id/eprint/13505/ http://ir.unimas.my/id/eprint/13505/1/Wan.pdf |
| _version_ | 1848837422500020224 |
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| author | Wan Sharifatun Handayani, Wan Zullkiplee Maya Asyikin, Mohd Ariff Hasnain, Hussain Wan Mohd Khairul Zainab Ngaini |
| author_facet | Wan Sharifatun Handayani, Wan Zullkiplee Maya Asyikin, Mohd Ariff Hasnain, Hussain Wan Mohd Khairul Zainab Ngaini |
| author_sort | Wan Sharifatun Handayani, Wan Zullkiplee |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR, 1H and 13C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline. |
| first_indexed | 2025-11-15T06:39:24Z |
| format | Article |
| id | unimas-13505 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:39:24Z |
| publishDate | 2016 |
| publisher | Taylor and Francis Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-135052023-03-29T03:58:31Z http://ir.unimas.my/id/eprint/13505/ Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents Wan Sharifatun Handayani, Wan Zullkiplee Maya Asyikin, Mohd Ariff Hasnain, Hussain Wan Mohd Khairul Zainab Ngaini QD Chemistry A series of tri-substituted thiourea derivatives were synthesized by the reaction of 1,3,5-triacetylbenzoyl isothiocyanate with aminoacids and aniline derivatives. All thiourea derivatives were characterized by FT-IR, 1H and 13C NMR spectroscopy. Antibacterial activities against wild-type Escherichia coli American Type Culture Collection 8739 were determined by use of the turbidimetric methodto evaluate the effect of varying amino groups on the synthesized thioureas. Tris-thiourea derivatives bearing ortho-chloroaryl substituents showed excellent antibacterial activity against E. coli with minimal inhibitory concentration (MIC) of 96 ppm. The optimum inhibition was dependent on the type of amines and the position of the halogen in aniline. Taylor and Francis Ltd. 2016 Article PeerReviewed text en http://ir.unimas.my/id/eprint/13505/1/Wan.pdf Wan Sharifatun Handayani, Wan Zullkiplee and Maya Asyikin, Mohd Ariff and Hasnain, Hussain and Wan Mohd Khairul and Zainab Ngaini (2016) Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents. Phosphorus, Sulfur and Silicon and the Related Elements. pp. 1-5. ISSN 10426507 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979623321&partnerID=40&md5=15b1431e4215fb7261537c029627baf9 DOI: 10.1080/10426507.2016.1192627 |
| spellingShingle | QD Chemistry Wan Sharifatun Handayani, Wan Zullkiplee Maya Asyikin, Mohd Ariff Hasnain, Hussain Wan Mohd Khairul Zainab Ngaini Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title_full | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title_fullStr | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title_full_unstemmed | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title_short | Bacteriostatic activities of N-substituted tris-thioureas bearing amino acid and aniline substituents |
| title_sort | bacteriostatic activities of n-substituted tris-thioureas bearing amino acid and aniline substituents |
| topic | QD Chemistry |
| url | http://ir.unimas.my/id/eprint/13505/ http://ir.unimas.my/id/eprint/13505/ http://ir.unimas.my/id/eprint/13505/ http://ir.unimas.my/id/eprint/13505/1/Wan.pdf |