Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit

Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit

Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete understanding of these roles. Standard experimental studies have limited usefulness in defining the complete biological significance of ribosomal proteins. An alternative strategy is via in silico analys...

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Main Authors: Ui-Hang, Edmund Sim, Chin-Ming, Er
Format: Article
Language:English
Published: International Academy Publishing (IAP) 2015
Subjects:
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/13008/
http://ir.unimas.my/id/eprint/13008/1/Structure-to-Function%20Computational%20Prediction%20of%20a%20Subset%20of%20Ribosomal%20Protiens%20%28abstract%29.pdf
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author Ui-Hang, Edmund Sim
Chin-Ming, Er
author_facet Ui-Hang, Edmund Sim
Chin-Ming, Er
author_sort Ui-Hang, Edmund Sim
building UNIMAS Institutional Repository
collection Online Access
description Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete understanding of these roles. Standard experimental studies have limited usefulness in defining the complete biological significance of ribosomal proteins. An alternative strategy is via in silico analysis. Here, we sought a sequence-to-structure-to-function approach to computationally predict the extra-ribosomal functions of a subset of ribosomal proteins of the small ribosome subunit, namely RPS12, RPS19, RPS20 and RPS24. Three-dimensional structure constructed from amino acid sequence was precisely matched with structural neighbours to extrapolate possible functions. Our analysis reveals new logical roles for these ribosomal proteins, of which represent important information for planning experimental and further in silico studies to elucidate their physiological roles.
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institution Universiti Malaysia Sarawak
institution_category Local University
language English
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publishDate 2015
publisher International Academy Publishing (IAP)
recordtype eprints
repository_type Digital Repository
spelling unimas-130082016-08-15T23:42:49Z http://ir.unimas.my/id/eprint/13008/ Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit Ui-Hang, Edmund Sim Chin-Ming, Er Q Science (General) Extra-ribosomal functions of ribosomal proteins have been widely accepted albeit an incomplete understanding of these roles. Standard experimental studies have limited usefulness in defining the complete biological significance of ribosomal proteins. An alternative strategy is via in silico analysis. Here, we sought a sequence-to-structure-to-function approach to computationally predict the extra-ribosomal functions of a subset of ribosomal proteins of the small ribosome subunit, namely RPS12, RPS19, RPS20 and RPS24. Three-dimensional structure constructed from amino acid sequence was precisely matched with structural neighbours to extrapolate possible functions. Our analysis reveals new logical roles for these ribosomal proteins, of which represent important information for planning experimental and further in silico studies to elucidate their physiological roles. International Academy Publishing (IAP) 2015 Article PeerReviewed text en http://ir.unimas.my/id/eprint/13008/1/Structure-to-Function%20Computational%20Prediction%20of%20a%20Subset%20of%20Ribosomal%20Protiens%20%28abstract%29.pdf Ui-Hang, Edmund Sim and Chin-Ming, Er (2015) Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit. International Journal of Bioscience, Biochemistry and Bioinformatics, 5 (2). ISSN 2010-3638 doi: 10.17706/ijbbb.2015.v5.100-110
spellingShingle Q Science (General)
Ui-Hang, Edmund Sim
Chin-Ming, Er
Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title_full Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title_fullStr Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title_full_unstemmed Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title_short Structure-to-Function Computational Prediction of a Subset of Ribosomal Proteins for the Small Ribosome Subunit
title_sort structure-to-function computational prediction of a subset of ribosomal proteins for the small ribosome subunit
topic Q Science (General)
url http://ir.unimas.my/id/eprint/13008/
http://ir.unimas.my/id/eprint/13008/
http://ir.unimas.my/id/eprint/13008/1/Structure-to-Function%20Computational%20Prediction%20of%20a%20Subset%20of%20Ribosomal%20Protiens%20%28abstract%29.pdf

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