Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors
Cancer is a class of diseases characterized by out-of-control cells' growth which affect cells and make them damaged. Many treatment options for cancer exist. Chemotherapy as an important treatment option is the use of drugs to treat cancer. The anticancer drug travels to the tumor and then dif...
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| Format: | Article |
| Language: | English |
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Hidawi Publishing Coperation
2016
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| Online Access: | http://ir.unimas.my/id/eprint/12824/ http://ir.unimas.my/id/eprint/12824/1/Mathematical-Based-Calculation-of-Drug-Penetration-Depth-in-Solid-Tumors_2016_BioMed-Research-International%20%28abstract%29.pdf |
| _version_ | 1848837281582940160 |
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| author | Namazi, H. Kulish, V.V. Wong, A. Nazeri, S. |
| author_facet | Namazi, H. Kulish, V.V. Wong, A. Nazeri, S. |
| author_sort | Namazi, H. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Cancer is a class of diseases characterized by out-of-control cells' growth which affect cells and make them damaged. Many treatment options for cancer exist. Chemotherapy as an important treatment option is the use of drugs to treat cancer. The anticancer drug travels to the tumor and then diffuses in it through capillaries. The diffusion of drugs in the solid tumor is limited by penetration depth which is different in case of different drugs and cancers. The computation of this depth is important as it helps physicians to investigate about treatment of infected tissue. Although many efforts have been made on studying and measuring drug penetration depth, less works have been done on computing this length from a mathematical point of view. In this paper, first we propose phase lagging model for diffusion of drug in the tumor. Then, using this model on one side and considering the classic diffusion on the other side, we compute the drug penetration depth in the solid tumor. This computed value of drug penetration depth is corroborated by comparison with the values measured by experiments. |
| first_indexed | 2025-11-15T06:37:10Z |
| format | Article |
| id | unimas-12824 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:37:10Z |
| publishDate | 2016 |
| publisher | Hidawi Publishing Coperation |
| recordtype | eprints |
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| spelling | unimas-128242016-08-07T22:28:18Z http://ir.unimas.my/id/eprint/12824/ Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors Namazi, H. Kulish, V.V. Wong, A. Nazeri, S. R Medicine (General) Cancer is a class of diseases characterized by out-of-control cells' growth which affect cells and make them damaged. Many treatment options for cancer exist. Chemotherapy as an important treatment option is the use of drugs to treat cancer. The anticancer drug travels to the tumor and then diffuses in it through capillaries. The diffusion of drugs in the solid tumor is limited by penetration depth which is different in case of different drugs and cancers. The computation of this depth is important as it helps physicians to investigate about treatment of infected tissue. Although many efforts have been made on studying and measuring drug penetration depth, less works have been done on computing this length from a mathematical point of view. In this paper, first we propose phase lagging model for diffusion of drug in the tumor. Then, using this model on one side and considering the classic diffusion on the other side, we compute the drug penetration depth in the solid tumor. This computed value of drug penetration depth is corroborated by comparison with the values measured by experiments. Hidawi Publishing Coperation 2016 Article PeerReviewed text en http://ir.unimas.my/id/eprint/12824/1/Mathematical-Based-Calculation-of-Drug-Penetration-Depth-in-Solid-Tumors_2016_BioMed-Research-International%20%28abstract%29.pdf Namazi, H. and Kulish, V.V. and Wong, A. and Nazeri, S. (2016) Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors. BioMed Research International, 2016. ISSN 2314-6133 https://www.scopus.com/record/display.uri?eid=2-s2.0-84976566364&origin=inward&txGid=0 DOI: 10.1155/2016/8437247 |
| spellingShingle | R Medicine (General) Namazi, H. Kulish, V.V. Wong, A. Nazeri, S. Mathematical Based Calculation of Drug Penetration Depth in Solid Tumors |
| title | Mathematical Based Calculation of Drug Penetration
Depth in Solid Tumors |
| title_full | Mathematical Based Calculation of Drug Penetration
Depth in Solid Tumors |
| title_fullStr | Mathematical Based Calculation of Drug Penetration
Depth in Solid Tumors |
| title_full_unstemmed | Mathematical Based Calculation of Drug Penetration
Depth in Solid Tumors |
| title_short | Mathematical Based Calculation of Drug Penetration
Depth in Solid Tumors |
| title_sort | mathematical based calculation of drug penetration
depth in solid tumors |
| topic | R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/12824/ http://ir.unimas.my/id/eprint/12824/ http://ir.unimas.my/id/eprint/12824/ http://ir.unimas.my/id/eprint/12824/1/Mathematical-Based-Calculation-of-Drug-Penetration-Depth-in-Solid-Tumors_2016_BioMed-Research-International%20%28abstract%29.pdf |