Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers
Polysaccharide-based nanoparticles have been developed as drug delivery nanocarriers for encapsulating and releasing optimum doses of drug at targeted sites over a predictable period of time. We have reported herein the successful loading of curcumin onto both native starch and starch-maleate nanopa...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Electrochemical Society Inc.
2015
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/12709/ |
| _version_ | 1848837256878489600 |
|---|---|
| author | Pang, S.C Chin, S.F. Nadirah, A. Tay, S.H. Yazid, S.N.A.M |
| author_facet | Pang, S.C Chin, S.F. Nadirah, A. Tay, S.H. Yazid, S.N.A.M |
| author_sort | Pang, S.C |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Polysaccharide-based nanoparticles have been developed as drug delivery nanocarriers for encapsulating and releasing optimum doses of drug at targeted sites over a predictable period of time. We have reported herein the successful loading of curcumin onto both native starch and starch-maleate nanoparticles prepared via in-situ nanoprecipitation in aqueous medium and water-in-oil emulsion, respectively. The physico-chemical characteristics of curcumin-loaded polysaccharide-based nanoparticles such as sizes, porosity, and hydrophilicity or hydrophobicity were subsequently optimized by tailoring synthesis parameters which include solvents, surfactants, cross-linkers, and polysaccharide precursors. Under optimum conditions, native starch nanoparticles with a mean diameter of 87 nm exhibited a maximum curcumin loading efficiency of 78%. Curcumin was observed to release from native starch nanoparticles at physiological pH in sustained and predictable manners over a period of 10 days. On the other hand, the diameter of curcumin-loaded starch-maleate nanoparticles varied between 30 nm and 110 nm and a mean diameter of 50 nm. The loading of curcumin onto starch-maleate nanoparticles occurred rapidly initially but declined gradually until the curcumin loading capacity of 15 mg/g was achieved within 12 hours. Curcumin-loaded starch-maleate nanoparticles exhibited a water solubility of 6.0 x 10-2 mg/mL, which was about 300 times higher than that of free curcumin. Increased water solubility coupled with desirable loading capacity and release kinetic profile of curcumin in polysaccharide-based nanoparticles should, in turn, lead to enhanced bioavailability of curcumin. The potential utility of native starch and starch-maleate nanoparticles as cost-effective polysaccharide-based drug delivery nanocarriers is therefore envisaged. |
| first_indexed | 2025-11-15T06:36:47Z |
| format | Article |
| id | unimas-12709 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| last_indexed | 2025-11-15T06:36:47Z |
| publishDate | 2015 |
| publisher | Electrochemical Society Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-127092016-07-28T03:22:09Z http://ir.unimas.my/id/eprint/12709/ Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers Pang, S.C Chin, S.F. Nadirah, A. Tay, S.H. Yazid, S.N.A.M TP Chemical technology Polysaccharide-based nanoparticles have been developed as drug delivery nanocarriers for encapsulating and releasing optimum doses of drug at targeted sites over a predictable period of time. We have reported herein the successful loading of curcumin onto both native starch and starch-maleate nanoparticles prepared via in-situ nanoprecipitation in aqueous medium and water-in-oil emulsion, respectively. The physico-chemical characteristics of curcumin-loaded polysaccharide-based nanoparticles such as sizes, porosity, and hydrophilicity or hydrophobicity were subsequently optimized by tailoring synthesis parameters which include solvents, surfactants, cross-linkers, and polysaccharide precursors. Under optimum conditions, native starch nanoparticles with a mean diameter of 87 nm exhibited a maximum curcumin loading efficiency of 78%. Curcumin was observed to release from native starch nanoparticles at physiological pH in sustained and predictable manners over a period of 10 days. On the other hand, the diameter of curcumin-loaded starch-maleate nanoparticles varied between 30 nm and 110 nm and a mean diameter of 50 nm. The loading of curcumin onto starch-maleate nanoparticles occurred rapidly initially but declined gradually until the curcumin loading capacity of 15 mg/g was achieved within 12 hours. Curcumin-loaded starch-maleate nanoparticles exhibited a water solubility of 6.0 x 10-2 mg/mL, which was about 300 times higher than that of free curcumin. Increased water solubility coupled with desirable loading capacity and release kinetic profile of curcumin in polysaccharide-based nanoparticles should, in turn, lead to enhanced bioavailability of curcumin. The potential utility of native starch and starch-maleate nanoparticles as cost-effective polysaccharide-based drug delivery nanocarriers is therefore envisaged. Electrochemical Society Inc. 2015 Article PeerReviewed Pang, S.C and Chin, S.F. and Nadirah, A. and Tay, S.H. and Yazid, S.N.A.M (2015) Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers. ECS Transactions, 66 (37). pp. 15-32. ISSN 1938-5862 https://www.scopus.com/record/display.uri?eid=2-s2.0-84940403657&origin=inward&txGid=0 DOI: 10.1149/06637.0015ecst |
| spellingShingle | TP Chemical technology Pang, S.C Chin, S.F. Nadirah, A. Tay, S.H. Yazid, S.N.A.M Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title | Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title_full | Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title_fullStr | Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title_full_unstemmed | Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title_short | Fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| title_sort | fabrication of polysaccharide-based nanoparticles as drug delivery nanocarriers |
| topic | TP Chemical technology |
| url | http://ir.unimas.my/id/eprint/12709/ http://ir.unimas.my/id/eprint/12709/ http://ir.unimas.my/id/eprint/12709/ |