Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi
Plasmodium cynomolgi is a malaria parasite that typically infects Asian macaque monkeys, and humans on rare occasions. P. cynomolgi serves as a model system for the human malaria parasite Plasmodium vivax, with which it shares such important biological characteristics as formation of a dormant liv...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier B.V.
2016
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| Online Access: | http://ir.unimas.my/id/eprint/12526/ http://ir.unimas.my/id/eprint/12526/1/Characterizing-the-genetic-diversity-of-the-monkey-malaria-parasite-Plasmodium-cynomolgi%20%28abstract%29.pdf |
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| author | Sutton, Patrick L. Zunping, Luo Paul C.S., Divis Friedrich, Volney K. Conway, D.J Balbir, Singh Barnwell, John W. Carltona, Jane M. Sullivan, Steven A. |
| author_facet | Sutton, Patrick L. Zunping, Luo Paul C.S., Divis Friedrich, Volney K. Conway, D.J Balbir, Singh Barnwell, John W. Carltona, Jane M. Sullivan, Steven A. |
| author_sort | Sutton, Patrick L. |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Plasmodium cynomolgi is a malaria parasite that typically infects Asian macaque monkeys, and humans on rare
occasions. P. cynomolgi serves as a model system for the human malaria parasite Plasmodium vivax, with which
it shares such important biological characteristics as formation of a dormant liver stage and a preference to
invade reticulocytes. While genomes of three P. cynomolgi strains have been sequenced, genetic diversity of
P. cynomolgi has not been widely investigated. To address this we developed the first panel of P. cynomolgi microsatellite
markers to genotype eleven P. cynomolgi laboratory strains and 18 field isolates fromSarawak,Malaysian
Borneo. We found diverse genotypes among most of the laboratory strains, though two nominally different
strains were found to be genetically identical. We also investigated sequence polymorphism in two erythrocyte
invasion gene families, the reticulocyte binding protein and Duffy binding protein genes, in these strains. Wealso
observed copy number variation in rbp genes. |
| first_indexed | 2025-11-15T06:36:07Z |
| format | Article |
| id | unimas-12526 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:36:07Z |
| publishDate | 2016 |
| publisher | Elsevier B.V. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-125262016-06-28T00:47:17Z http://ir.unimas.my/id/eprint/12526/ Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi Sutton, Patrick L. Zunping, Luo Paul C.S., Divis Friedrich, Volney K. Conway, D.J Balbir, Singh Barnwell, John W. Carltona, Jane M. Sullivan, Steven A. QR Microbiology R Medicine (General) Plasmodium cynomolgi is a malaria parasite that typically infects Asian macaque monkeys, and humans on rare occasions. P. cynomolgi serves as a model system for the human malaria parasite Plasmodium vivax, with which it shares such important biological characteristics as formation of a dormant liver stage and a preference to invade reticulocytes. While genomes of three P. cynomolgi strains have been sequenced, genetic diversity of P. cynomolgi has not been widely investigated. To address this we developed the first panel of P. cynomolgi microsatellite markers to genotype eleven P. cynomolgi laboratory strains and 18 field isolates fromSarawak,Malaysian Borneo. We found diverse genotypes among most of the laboratory strains, though two nominally different strains were found to be genetically identical. We also investigated sequence polymorphism in two erythrocyte invasion gene families, the reticulocyte binding protein and Duffy binding protein genes, in these strains. Wealso observed copy number variation in rbp genes. Elsevier B.V. 2016 Article PeerReviewed text en http://ir.unimas.my/id/eprint/12526/1/Characterizing-the-genetic-diversity-of-the-monkey-malaria-parasite-Plasmodium-cynomolgi%20%28abstract%29.pdf Sutton, Patrick L. and Zunping, Luo and Paul C.S., Divis and Friedrich, Volney K. and Conway, D.J and Balbir, Singh and Barnwell, John W. and Carltona, Jane M. and Sullivan, Steven A. (2016) Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi. Infection, Genetics and Evolution, 40. pp. 243-252. ISSN 1567-1348 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961154941&partnerID=40&md5=d782c58f224108283be0f3dbe34d38a8 http://dx.doi.org/10.1016/j.meegid.2016.03.009 |
| spellingShingle | QR Microbiology R Medicine (General) Sutton, Patrick L. Zunping, Luo Paul C.S., Divis Friedrich, Volney K. Conway, D.J Balbir, Singh Barnwell, John W. Carltona, Jane M. Sullivan, Steven A. Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title | Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title_full | Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title_fullStr | Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title_full_unstemmed | Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title_short | Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi |
| title_sort | characterizing the genetic diversity of the monkey malaria parasite plasmodium cynomolgi |
| topic | QR Microbiology R Medicine (General) |
| url | http://ir.unimas.my/id/eprint/12526/ http://ir.unimas.my/id/eprint/12526/ http://ir.unimas.my/id/eprint/12526/ http://ir.unimas.my/id/eprint/12526/1/Characterizing-the-genetic-diversity-of-the-monkey-malaria-parasite-Plasmodium-cynomolgi%20%28abstract%29.pdf |