Aleukemic bcr-abl positive granulocytic sarcoma
Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl, PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘prima...
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| Format: | Article |
| Language: | English |
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Elsevier Ltd.
2009
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| Online Access: | http://ir.unimas.my/id/eprint/12279/ http://ir.unimas.my/id/eprint/12279/7/Aleukemic%20bcr-abl%20positive%20granulocytic%20sarcoma%20%28abstract%29.pdf |
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| author | Kuan, Jew-Win Pathmanathan, Rajadurai Chang, Kian Meng Tan, Sen Mui |
| author_facet | Kuan, Jew-Win Pathmanathan, Rajadurai Chang, Kian Meng Tan, Sen Mui |
| author_sort | Kuan, Jew-Win |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders.
With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl,
PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘primary’
GS are questionable. We report a case of primary GS where the tumor mass bcr-abl translocation was
demonstrated by fluorescent in situ hybridization in which there was no evidence of chronic myeloid
leukemia (CML). This is an important finding as it highlights the possibility that CML may present as a
sole extramedullary form, and illustrates potential treatment by tyrosine kinase inhibitor. |
| first_indexed | 2025-11-15T06:35:20Z |
| format | Article |
| id | unimas-12279 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:35:20Z |
| publishDate | 2009 |
| publisher | Elsevier Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-122792016-06-10T07:44:12Z http://ir.unimas.my/id/eprint/12279/ Aleukemic bcr-abl positive granulocytic sarcoma Kuan, Jew-Win Pathmanathan, Rajadurai Chang, Kian Meng Tan, Sen Mui RZ Other systems of medicine Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl, PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘primary’ GS are questionable. We report a case of primary GS where the tumor mass bcr-abl translocation was demonstrated by fluorescent in situ hybridization in which there was no evidence of chronic myeloid leukemia (CML). This is an important finding as it highlights the possibility that CML may present as a sole extramedullary form, and illustrates potential treatment by tyrosine kinase inhibitor. Elsevier Ltd. 2009 Article PeerReviewed text en http://ir.unimas.my/id/eprint/12279/7/Aleukemic%20bcr-abl%20positive%20granulocytic%20sarcoma%20%28abstract%29.pdf Kuan, Jew-Win and Pathmanathan, Rajadurai and Chang, Kian Meng and Tan, Sen Mui (2009) Aleukemic bcr-abl positive granulocytic sarcoma. Leukemia Research, 33 (11). pp. 1574-1577. ISSN 0145-2126 doi:10.1016/j.leukres.2009.01.016 |
| spellingShingle | RZ Other systems of medicine Kuan, Jew-Win Pathmanathan, Rajadurai Chang, Kian Meng Tan, Sen Mui Aleukemic bcr-abl positive granulocytic sarcoma |
| title | Aleukemic bcr-abl positive granulocytic sarcoma |
| title_full | Aleukemic bcr-abl positive granulocytic sarcoma |
| title_fullStr | Aleukemic bcr-abl positive granulocytic sarcoma |
| title_full_unstemmed | Aleukemic bcr-abl positive granulocytic sarcoma |
| title_short | Aleukemic bcr-abl positive granulocytic sarcoma |
| title_sort | aleukemic bcr-abl positive granulocytic sarcoma |
| topic | RZ Other systems of medicine |
| url | http://ir.unimas.my/id/eprint/12279/ http://ir.unimas.my/id/eprint/12279/ http://ir.unimas.my/id/eprint/12279/7/Aleukemic%20bcr-abl%20positive%20granulocytic%20sarcoma%20%28abstract%29.pdf |