Aleukemic bcr-abl positive granulocytic sarcoma
Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders. With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl, PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘prima...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd.
2009
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/12279/ http://ir.unimas.my/id/eprint/12279/7/Aleukemic%20bcr-abl%20positive%20granulocytic%20sarcoma%20%28abstract%29.pdf |
| Summary: | Granulocytic sarcoma (GS) can occur de novo or in association with intramedullary myeloid disorders.
With the advent of sophisticated molecular detection techniques to detect diagnostic genes such as bcrabl,
PML-RARAandCBFB/MYH11 in bone marrowor peripheral blood,many cases of the so called ‘primary’
GS are questionable. We report a case of primary GS where the tumor mass bcr-abl translocation was
demonstrated by fluorescent in situ hybridization in which there was no evidence of chronic myeloid
leukemia (CML). This is an important finding as it highlights the possibility that CML may present as a
sole extramedullary form, and illustrates potential treatment by tyrosine kinase inhibitor. |
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