Early clearance of Chikungunya virus in children is associated with a strong innate immune response
Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infectio...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016
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| Online Access: | http://ir.unimas.my/id/eprint/12144/ http://ir.unimas.my/id/eprint/12144/1/Early%20clearance%20of%20Chikungunya%20virus%20in%20children%20is%20associated%20with%20a%20strong%20innate%20immune%20response.pdf |
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| author | Diane, Simarmata Ng, David Chun Ern Yiu-Wing, Kam Lee, Bernett Magdline Sia, Henry Sum Her, Zhisheng Chow, Angela Yee-Sin, Leo Jane, Cardosa Perera, David Ooi, Mong How Ng, Lisa F.P. |
| author_facet | Diane, Simarmata Ng, David Chun Ern Yiu-Wing, Kam Lee, Bernett Magdline Sia, Henry Sum Her, Zhisheng Chow, Angela Yee-Sin, Leo Jane, Cardosa Perera, David Ooi, Mong How Ng, Lisa F.P. |
| author_sort | Diane, Simarmata |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children. |
| first_indexed | 2025-11-15T06:34:50Z |
| format | Article |
| id | unimas-12144 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:34:50Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-121442016-06-24T02:18:42Z http://ir.unimas.my/id/eprint/12144/ Early clearance of Chikungunya virus in children is associated with a strong innate immune response Diane, Simarmata Ng, David Chun Ern Yiu-Wing, Kam Lee, Bernett Magdline Sia, Henry Sum Her, Zhisheng Chow, Angela Yee-Sin, Leo Jane, Cardosa Perera, David Ooi, Mong How Ng, Lisa F.P. QR355 Virology R Medicine (General) RJ Pediatrics Chikungunya fever (CHIKF) is a global infectious disease which can affect a wide range of age groups. The pathological and immunological response upon Chikungunya virus (CHIKV) infection have been reported over the last few years. However, the clinical profile and immune response upon CHIKV infection in children remain largely unknown. In this study, we analyzed the clinical and immunological response, focusing on the cytokine/chemokine profile in a CHIKV-infected pediatric cohort from Sarawak, Malaysia. Unique immune mediators triggered upon CHIKV infection were identified through meta-analysis of the immune signatures between this pediatric group and cohorts from previous outbreaks. The data generated from this study revealed that a broad spectrum of cytokines/chemokines is up-regulated in a sub-group of virus-infected children stratified according to their viremic status during hospitalization. Furthermore, different immune mediator profiles (the levels of pro-inflammatory cytokines, chemokines and growth and other factors) were observed between children and adults. This study gives an important insight to understand the immune response of CHIKV infection in children and would aid in the development of better prognostics and clinical management for children. Nature Publishing Group 2016-05-16 Article PeerReviewed text en http://ir.unimas.my/id/eprint/12144/1/Early%20clearance%20of%20Chikungunya%20virus%20in%20children%20is%20associated%20with%20a%20strong%20innate%20immune%20response.pdf Diane, Simarmata and Ng, David Chun Ern and Yiu-Wing, Kam and Lee, Bernett and Magdline Sia, Henry Sum and Her, Zhisheng and Chow, Angela and Yee-Sin, Leo and Jane, Cardosa and Perera, David and Ooi, Mong How and Ng, Lisa F.P. (2016) Early clearance of Chikungunya virus in children is associated with a strong innate immune response. Scientific Reports, 6 (26097). ISSN 2045-2322 http://www.nature.com/scientificreports doi:10.1038/srep26097 |
| spellingShingle | QR355 Virology R Medicine (General) RJ Pediatrics Diane, Simarmata Ng, David Chun Ern Yiu-Wing, Kam Lee, Bernett Magdline Sia, Henry Sum Her, Zhisheng Chow, Angela Yee-Sin, Leo Jane, Cardosa Perera, David Ooi, Mong How Ng, Lisa F.P. Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title | Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title_full | Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title_fullStr | Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title_full_unstemmed | Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title_short | Early clearance of Chikungunya virus in children is associated with a strong innate immune response |
| title_sort | early clearance of chikungunya virus in children is associated with a strong innate immune response |
| topic | QR355 Virology R Medicine (General) RJ Pediatrics |
| url | http://ir.unimas.my/id/eprint/12144/ http://ir.unimas.my/id/eprint/12144/ http://ir.unimas.my/id/eprint/12144/ http://ir.unimas.my/id/eprint/12144/1/Early%20clearance%20of%20Chikungunya%20virus%20in%20children%20is%20associated%20with%20a%20strong%20innate%20immune%20response.pdf |