Optimization of MISCORE-based Motif Identification Systems
Identification of motifs in DNA sequences using classification techniques is one of computational approaches to discovering novel binding sites. In the previous work [16], we proposed a simple and effective method for motif detection using a single crisp rule governed by a mismatch-based matrix simi...
| Main Authors: | , |
|---|---|
| Format: | Proceeding |
| Language: | English |
| Published: |
IEEE
2009
|
| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/11946/ http://ir.unimas.my/id/eprint/11946/1/Optimization%20of%20MISCORE_abstract.pdf |
| Summary: | Identification of motifs in DNA sequences using classification techniques is one of computational approaches to discovering novel binding sites. In the previous work [16], we proposed a simple and effective method for motif detection using a single crisp rule governed by a mismatch-based matrix similarity score (MISCORE). In this paper, we consider the problem
of finding suitable motif cut-off value for MISCORE-based motif identification systems using cost-sensitivity metric. We utilize phylogenetic footprinting data to estimate the parameters in the cost function. We also extend the MISCORE to include entropy to weigh each motif model position to minimize the false positive rate. The performance evaluation is done by using artificial and real DNA sequences. The results demonstrate the feasibility and
usefulness of our proposed approach for model based cut-off
value estimation. |
|---|