Antibiosis activities against burkholderia pseudomallei by other burkholderia species
Burkholderia pseudomallei is known as a significant causative agent of melioidosis and a versatile species of bacteria which inhabit diverse ecological niches including soil and water sources. By studying and understanding the nature of antibiosis activities against B. pseudomallei by other antagoni...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
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Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/11244/ http://ir.unimas.my/id/eprint/11244/1/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%2824%20pages%29.pdf http://ir.unimas.my/id/eprint/11244/2/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%28fulltext%29.pdf |
| _version_ | 1848836970976903168 |
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| author | Nur Ezzah, binti Sainei |
| author_facet | Nur Ezzah, binti Sainei |
| author_sort | Nur Ezzah, binti Sainei |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Burkholderia pseudomallei is known as a significant causative agent of melioidosis and a versatile species of bacteria which inhabit diverse ecological niches including soil and water sources. By studying and understanding the nature of antibiosis activities against B. pseudomallei by other antagonistic Burkholderia species, Burkholderia spp. that are potentially capable of inhibiting the growth of B. pseudomallei are determined to serve as possible biocontrol for the widespread of melioidosis. In this study, certain Burkholderia spp. such as Burkholderia cepacia-complex and Burkholderia ubonensis displayed strong inhibition against B. pseudomallei. Bacteriocins in a cell free state (CFS) isolated from Burkholderia spp. were found to inhibit B. pseudomallei as well. Further characterization of the bacteriocins through various heat treatments indicated that the stability of bacteriocins to heat treatments varies greatly depending on strain-type and exposure to alkaline conditions substantially enhanced the inhibitory activities of the bacteriocins. Subjection to trypsin digestion and freezing showed that the bacteriocins contained both protease-sensitive and phage-like compounds. |
| first_indexed | 2025-11-15T06:32:14Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-11244 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:32:14Z |
| publishDate | 2015 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-112442016-07-18T07:12:57Z http://ir.unimas.my/id/eprint/11244/ Antibiosis activities against burkholderia pseudomallei by other burkholderia species Nur Ezzah, binti Sainei SB Plant culture Burkholderia pseudomallei is known as a significant causative agent of melioidosis and a versatile species of bacteria which inhabit diverse ecological niches including soil and water sources. By studying and understanding the nature of antibiosis activities against B. pseudomallei by other antagonistic Burkholderia species, Burkholderia spp. that are potentially capable of inhibiting the growth of B. pseudomallei are determined to serve as possible biocontrol for the widespread of melioidosis. In this study, certain Burkholderia spp. such as Burkholderia cepacia-complex and Burkholderia ubonensis displayed strong inhibition against B. pseudomallei. Bacteriocins in a cell free state (CFS) isolated from Burkholderia spp. were found to inhibit B. pseudomallei as well. Further characterization of the bacteriocins through various heat treatments indicated that the stability of bacteriocins to heat treatments varies greatly depending on strain-type and exposure to alkaline conditions substantially enhanced the inhibitory activities of the bacteriocins. Subjection to trypsin digestion and freezing showed that the bacteriocins contained both protease-sensitive and phage-like compounds. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/11244/1/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%2824%20pages%29.pdf text en http://ir.unimas.my/id/eprint/11244/2/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%28fulltext%29.pdf Nur Ezzah, binti Sainei (2015) Antibiosis activities against burkholderia pseudomallei by other burkholderia species. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | SB Plant culture Nur Ezzah, binti Sainei Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title | Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title_full | Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title_fullStr | Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title_full_unstemmed | Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title_short | Antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| title_sort | antibiosis activities against burkholderia pseudomallei by other burkholderia species |
| topic | SB Plant culture |
| url | http://ir.unimas.my/id/eprint/11244/ http://ir.unimas.my/id/eprint/11244/1/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%2824%20pages%29.pdf http://ir.unimas.my/id/eprint/11244/2/Antibiosis%20Activities%20Against%20Burkholderia%20Pseudomallei%20by%20Other%20Burkholderia%20Species.%20%28fulltext%29.pdf |