Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity
Thiourea and its derivatives have been actively studied in recent years mostly in their biological activities. This study focused on the synthesis and characterization of aspirinthiourea derivatives. The syntheses have been done via the reaction of acetylsalicyloyl chloride with series of amines. Th...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
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Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/11049/ http://ir.unimas.my/id/eprint/11049/3/Choi%20Ching%20Liang%2024pgs.pdf http://ir.unimas.my/id/eprint/11049/6/Choi%20Ching%20Liang%20ft.pdf |
| _version_ | 1848836922732969984 |
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| author | Choi, Ching Liang |
| author_facet | Choi, Ching Liang |
| author_sort | Choi, Ching Liang |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Thiourea and its derivatives have been actively studied in recent years mostly in their biological activities. This study focused on the synthesis and characterization of aspirinthiourea derivatives. The syntheses have been done via the reaction of acetylsalicyloyl chloride with series of amines. The long chains of amine formed by using 4-hydroxyl acetanilide and a series of bromoalkane have been synthesized. The synthesis aspirinthiourea derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR) and 1H NMR spectroscopy. The antibacterial properties of the synthesized compound were determined by disc diffusion method against Escherichia Coli (E.coli). However, the newly synthesized aspirin-thiourea derivatives show intermediate antibacterial activity against E.coli. The effect of the structure of the compounds on antibacterial activity is discussed. |
| first_indexed | 2025-11-15T06:31:28Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-11049 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:31:28Z |
| publishDate | 2015 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-110492023-01-20T08:04:52Z http://ir.unimas.my/id/eprint/11049/ Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity Choi, Ching Liang RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Thiourea and its derivatives have been actively studied in recent years mostly in their biological activities. This study focused on the synthesis and characterization of aspirinthiourea derivatives. The syntheses have been done via the reaction of acetylsalicyloyl chloride with series of amines. The long chains of amine formed by using 4-hydroxyl acetanilide and a series of bromoalkane have been synthesized. The synthesis aspirinthiourea derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), 13C nuclear magnetic resonance (NMR) and 1H NMR spectroscopy. The antibacterial properties of the synthesized compound were determined by disc diffusion method against Escherichia Coli (E.coli). However, the newly synthesized aspirin-thiourea derivatives show intermediate antibacterial activity against E.coli. The effect of the structure of the compounds on antibacterial activity is discussed. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/11049/3/Choi%20Ching%20Liang%2024pgs.pdf text en http://ir.unimas.my/id/eprint/11049/6/Choi%20Ching%20Liang%20ft.pdf Choi, Ching Liang (2015) Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Choi, Ching Liang Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title | Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title_full | Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title_fullStr | Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title_full_unstemmed | Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title_short | Synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| title_sort | synthesis and characterization of aspirin-thiourea derivatives and their antibacterial activity |
| topic | RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine |
| url | http://ir.unimas.my/id/eprint/11049/ http://ir.unimas.my/id/eprint/11049/3/Choi%20Ching%20Liang%2024pgs.pdf http://ir.unimas.my/id/eprint/11049/6/Choi%20Ching%20Liang%20ft.pdf |