Synthesis of aspirin-chalcone derivatives and their antibacterial activity
Aspirin and chalcone have long been used for its medicinal purpose due to its biological activity. This research focused on the synthesis of aspirin-chalcone derivatives resulting from the reactions of chalcone intermediate with acetylsalicyloyl chloride. Aspirinchalcone derivatives have been syn...
| Main Author: | |
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/10833/ http://ir.unimas.my/id/eprint/10833/1/Ji.pdf http://ir.unimas.my/id/eprint/10833/4/Lim%20Ji%20ft.pdf |
| _version_ | 1848836870067191808 |
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| author | Lim, Ji Yuan |
| author_facet | Lim, Ji Yuan |
| author_sort | Lim, Ji Yuan |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Aspirin and chalcone have long been used for its medicinal purpose due to its biological
activity. This research focused on the synthesis of aspirin-chalcone derivatives resulting
from the reactions of chalcone intermediate with acetylsalicyloyl chloride. Aspirinchalcone
derivatives have been synthesized. The successfully synthesized compounds were
characterized using FTIR, 1H NMR and 13C NMR. Antibacterial assay was carried out
using disc diffusion method against the growth of Escherichia coli ATCC 29522. However,
the result indicated that the newly synthesized aspirin-chalcone derivatives showed no
antibacterial activity against E.coli. |
| first_indexed | 2025-11-15T06:30:38Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-10833 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:30:38Z |
| publishDate | 2015 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-108332024-02-20T07:50:31Z http://ir.unimas.my/id/eprint/10833/ Synthesis of aspirin-chalcone derivatives and their antibacterial activity Lim, Ji Yuan R Medicine (General) RM Therapeutics. Pharmacology Aspirin and chalcone have long been used for its medicinal purpose due to its biological activity. This research focused on the synthesis of aspirin-chalcone derivatives resulting from the reactions of chalcone intermediate with acetylsalicyloyl chloride. Aspirinchalcone derivatives have been synthesized. The successfully synthesized compounds were characterized using FTIR, 1H NMR and 13C NMR. Antibacterial assay was carried out using disc diffusion method against the growth of Escherichia coli ATCC 29522. However, the result indicated that the newly synthesized aspirin-chalcone derivatives showed no antibacterial activity against E.coli. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/10833/1/Ji.pdf text en http://ir.unimas.my/id/eprint/10833/4/Lim%20Ji%20ft.pdf Lim, Ji Yuan (2015) Synthesis of aspirin-chalcone derivatives and their antibacterial activity. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | R Medicine (General) RM Therapeutics. Pharmacology Lim, Ji Yuan Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title | Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title_full | Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title_fullStr | Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title_full_unstemmed | Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title_short | Synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| title_sort | synthesis of aspirin-chalcone derivatives and their antibacterial activity |
| topic | R Medicine (General) RM Therapeutics. Pharmacology |
| url | http://ir.unimas.my/id/eprint/10833/ http://ir.unimas.my/id/eprint/10833/1/Ji.pdf http://ir.unimas.my/id/eprint/10833/4/Lim%20Ji%20ft.pdf |