Effects of synthesis parameters on drug loading capacity of starch nanoparticles
Using simple nanoprecipitation, sago, tapioca and soluble starch were being used to prepare starch nanoparticles (St-NPs). Various concentrations of native starch (NS) solutions ranging from from 0.1 to 5.0% w/v were being prepared. NS concentration and type of NS were found to affect morphology and...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English |
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Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/10820/ http://ir.unimas.my/id/eprint/10820/8/Effects%20of%20Synthesis%20Parameters%20on%20Drug%20Loading%20Capacity%20of%20Starch%20Nanoparticles%20%28fulltext%29.pdf |
| Summary: | Using simple nanoprecipitation, sago, tapioca and soluble starch were being used to prepare starch nanoparticles (St-NPs). Various concentrations of native starch (NS) solutions ranging from from 0.1 to 5.0% w/v were being prepared. NS concentration and type of NS were found to affect morphology and particle size of St-NPs. Morphology displayed the three NS types of nanoparticles that synthesized at 1% w/v started to consist of relatively discrete and homogeneous nanoparticles. Drug absorption technique was carried out to load starch nanoparticles with Methylene Blue (MB) as a model drug. It was found that various formulation parameters such as type of NS, concentration of NS, drug loading time and drug concentration affected loading capacity and loading efficiency of MB onto St-NPs. Highest loading capacity and loading capacity of MB loaded St-NPs were attained when sago starch were prepared into 3% w/v NS concentration with 5 hours drug loading time. Increasing MB concentration enhanced loading capacity, whereas, overshot MB concentration beyond 0.6 mg/mL eventually decreased loading efficiency of St-NPs.
Keywords: starch nanoparticles, nanoprecipitation, drug absorption, drug loading capacity, |
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