Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats
The present study appraised the hepatoprotective effects of aqueous leaf extract of Camellia sinensis against carbon tetrachloride (CCl4)-induced liver injury in rats. The 100 and 200 mg kg-1 b.wt. of Camellia sinensis and 100 mg kg-1 b.wt. Silymarin was administered orally to separate groups of rat...
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Academic Journals Inc., USA
2015
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| Online Access: | http://ir.unimas.my/id/eprint/10717/ http://ir.unimas.my/id/eprint/10717/1/NO%2097%20Protective%20effects%20of%20camellia%20sinensis%20leaf%20extract%20against%20carbon%20tetrachloride-induced%20liver%20injury%20in%20rats%20%28abstract%29.pdf |
| _version_ | 1848836844576309248 |
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| author | Wakawa, Hy Md., Ira |
| author_facet | Wakawa, Hy Md., Ira |
| author_sort | Wakawa, Hy |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | The present study appraised the hepatoprotective effects of aqueous leaf extract of Camellia sinensis against carbon tetrachloride (CCl4)-induced liver injury in rats. The 100 and 200 mg kg-1 b.wt. of Camellia sinensis and 100 mg kg-1 b.wt. Silymarin was administered orally to separate groups of rats for 7 days prior to CCl4 administration. A significant decrease (p<0.05) was observed in both the groups treated with 100 and 200 mg kg-1 b.wt. of the leaf extract and Silymarin on the levels of the enzymes and non-enzyme markers of tissue damage and lipid peroxidation, with no significant changes in the relative organ weight of the treated groups. This result shows that the leaf extract of Camellia sinensis contains some phytochemical(s) that can protect the liver against CCl4-induced injury in rats. |
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| format | Article |
| id | unimas-10717 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:30:13Z |
| publishDate | 2015 |
| publisher | Academic Journals Inc., USA |
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| spelling | unimas-107172016-10-24T06:45:49Z http://ir.unimas.my/id/eprint/10717/ Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats Wakawa, Hy Md., Ira GE Environmental Sciences The present study appraised the hepatoprotective effects of aqueous leaf extract of Camellia sinensis against carbon tetrachloride (CCl4)-induced liver injury in rats. The 100 and 200 mg kg-1 b.wt. of Camellia sinensis and 100 mg kg-1 b.wt. Silymarin was administered orally to separate groups of rats for 7 days prior to CCl4 administration. A significant decrease (p<0.05) was observed in both the groups treated with 100 and 200 mg kg-1 b.wt. of the leaf extract and Silymarin on the levels of the enzymes and non-enzyme markers of tissue damage and lipid peroxidation, with no significant changes in the relative organ weight of the treated groups. This result shows that the leaf extract of Camellia sinensis contains some phytochemical(s) that can protect the liver against CCl4-induced injury in rats. Academic Journals Inc., USA 2015 Article PeerReviewed text en http://ir.unimas.my/id/eprint/10717/1/NO%2097%20Protective%20effects%20of%20camellia%20sinensis%20leaf%20extract%20against%20carbon%20tetrachloride-induced%20liver%20injury%20in%20rats%20%28abstract%29.pdf Wakawa, Hy and Md., Ira (2015) Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats. Asian Journal of Biochemistry, 10 (2). pp. 86-92. ISSN 1815-9931 http://www.scopus.com/inward/record.url?eid=2-s2.0-84936775083&partnerID=40&md5=5b1b04a40e5a5f8204f4d3123b6dc32e DOI: 10.3923/ajb.2015.86.92 |
| spellingShingle | GE Environmental Sciences Wakawa, Hy Md., Ira Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title | Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title_full | Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title_fullStr | Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title_full_unstemmed | Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title_short | Protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| title_sort | protective effects of camellia sinensis leaf extract against carbon tetrachloride-induced liver injury in rats |
| topic | GE Environmental Sciences |
| url | http://ir.unimas.my/id/eprint/10717/ http://ir.unimas.my/id/eprint/10717/ http://ir.unimas.my/id/eprint/10717/ http://ir.unimas.my/id/eprint/10717/1/NO%2097%20Protective%20effects%20of%20camellia%20sinensis%20leaf%20extract%20against%20carbon%20tetrachloride-induced%20liver%20injury%20in%20rats%20%28abstract%29.pdf |