Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach
Ribosomal proteins (RPs) are the main component of ribosomes and play important roles in protein biosynthesis. Besides, several of them are shown to have extraribosomal functions. In this research, we used bioinformatics approach in finding the interaction between the ribosomal protein S3 (RPS3) and...
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| Format: | Final Year Project Report / IMRAD |
| Language: | English English |
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Universiti Malaysia Sarawak, (UNIMAS)
2015
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| Online Access: | http://ir.unimas.my/id/eprint/10517/ http://ir.unimas.my/id/eprint/10517/1/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%2824pgs%29.pdf http://ir.unimas.my/id/eprint/10517/2/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%28fulltext%29.pdf |
| _version_ | 1848836798265950208 |
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| author | Nazatul Syahira, bt. Roslan |
| author_facet | Nazatul Syahira, bt. Roslan |
| author_sort | Nazatul Syahira, bt. Roslan |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Ribosomal proteins (RPs) are the main component of ribosomes and play important roles in protein biosynthesis. Besides, several of them are shown to have extraribosomal functions. In this research, we used bioinformatics approach in finding the interaction between the ribosomal protein S3 (RPS3) and ribosomal protein S12 (RPS12) with their protein partners. Our results discovered that RPS3 interacts with Epidermal Growth Factor Receptor (EGFR) and 14-3-3 protein epsilon (YWHAE). RPS3 is predicted to inhibit the function of EGFR and YWHAE. RPS12 interacts with Transcription Elongation Factor B Polypeptide (ELOB) and Ski-like protein (SKIL). Hence, it is predicted to interrupt the function of ELOB and SKIL. |
| first_indexed | 2025-11-15T06:29:29Z |
| format | Final Year Project Report / IMRAD |
| id | unimas-10517 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T06:29:29Z |
| publishDate | 2015 |
| publisher | Universiti Malaysia Sarawak, (UNIMAS) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-105172016-02-11T07:55:01Z http://ir.unimas.my/id/eprint/10517/ Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach Nazatul Syahira, bt. Roslan Q Science (General) Ribosomal proteins (RPs) are the main component of ribosomes and play important roles in protein biosynthesis. Besides, several of them are shown to have extraribosomal functions. In this research, we used bioinformatics approach in finding the interaction between the ribosomal protein S3 (RPS3) and ribosomal protein S12 (RPS12) with their protein partners. Our results discovered that RPS3 interacts with Epidermal Growth Factor Receptor (EGFR) and 14-3-3 protein epsilon (YWHAE). RPS3 is predicted to inhibit the function of EGFR and YWHAE. RPS12 interacts with Transcription Elongation Factor B Polypeptide (ELOB) and Ski-like protein (SKIL). Hence, it is predicted to interrupt the function of ELOB and SKIL. Universiti Malaysia Sarawak, (UNIMAS) 2015 Final Year Project Report / IMRAD NonPeerReviewed text en http://ir.unimas.my/id/eprint/10517/1/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%2824pgs%29.pdf text en http://ir.unimas.my/id/eprint/10517/2/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%28fulltext%29.pdf Nazatul Syahira, bt. Roslan (2015) Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach. [Final Year Project Report / IMRAD] (Unpublished) |
| spellingShingle | Q Science (General) Nazatul Syahira, bt. Roslan Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title | Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title_full | Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title_fullStr | Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title_full_unstemmed | Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title_short | Identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, RPS3 and RPS12 via In Silico approach |
| title_sort | identification of logical extra-ribosomal functions mediated by the ribosomal protein genes, rps3 and rps12 via in silico approach |
| topic | Q Science (General) |
| url | http://ir.unimas.my/id/eprint/10517/ http://ir.unimas.my/id/eprint/10517/1/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%2824pgs%29.pdf http://ir.unimas.my/id/eprint/10517/2/Identification%20of%20Logical%20Extra-Ribosomal%20Functions%20Mediated%20by%20The%20Ribosomal%20Protein%20Genes%2C%20RPS3%20and%20RPS12%20via%20In%20Silico%20Approach%20%28fulltext%29.pdf |