Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi

Malaria cases due to the zoonotic parasite P. knowlesi are being increasingly reported throughout Southeast Asia and in travelers returning from the region. To test for evidence of signatures of selection or unusual population structure in this parasite, we surveyed genome sequence diversity in 48 c...

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Main Authors: Assefa, S., Lim, C., Preston, M.D., Duffy, C.W., Nair, M.B., Adroub, S.A., Kadir, K.A., Goldberg, J.M., Neafsey, D.E., Divis, Paul Cliff Simon, Clark, T.G., Duraisingh, M.T., Conway, D.J., Pain, A., Singh, B.
Format: Article
Language:English
Published: Proceedings of the National Academy 2015
Subjects:
Online Access:http://ir.unimas.my/id/eprint/10250/
http://ir.unimas.my/id/eprint/10250/1/2015_PNAS_PkGenomeFinal.pdf
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author Assefa, S.
Lim, C.
Preston, M.D.
Duffy, C.W.
Nair, M.B.
Adroub, S.A.
Kadir, K.A.
Goldberg, J.M.
Neafsey, D.E.
Divis, Paul Cliff Simon
Clark, T.G.
Duraisingh, M.T.
Conway, D.J.
Pain, A.
Singh, B.
author_facet Assefa, S.
Lim, C.
Preston, M.D.
Duffy, C.W.
Nair, M.B.
Adroub, S.A.
Kadir, K.A.
Goldberg, J.M.
Neafsey, D.E.
Divis, Paul Cliff Simon
Clark, T.G.
Duraisingh, M.T.
Conway, D.J.
Pain, A.
Singh, B.
author_sort Assefa, S.
building UNIMAS Institutional Repository
collection Online Access
description Malaria cases due to the zoonotic parasite P. knowlesi are being increasingly reported throughout Southeast Asia and in travelers returning from the region. To test for evidence of signatures of selection or unusual population structure in this parasite, we surveyed genome sequence diversity in 48 clinical isolates recently sampled from Malaysian Borneo and 5 lines maintained in laboratory rhesus macaques after isolation in the 1960s from Peninsular Malaysia and the Philippines. Overall genome-wide nucleotide diversity (π = 6.03 x 10-3) was much higher than has been seen in worldwide samples of either of the major endemic malaria parasite species P. falciparum and P. vivax. A remarkable substructure is revealed within P. knowlesi, consisting of two major sympatric clusters of the clinical isolates, and a third cluster comprising the laboratory isolates. There was deep differentiation between the two clusters of clinical isolates (mean genome-wide FST = 0.21, with 9,293 SNPs having fixed differences of FST = 1.0). This showed marked heterogeneity across the genome, mean FST values of different chromosomes ranging from 0.08 to 0.34, with further significant variation across regions within several chromosomes. Analysis of the largest cluster (Cluster 1, 38 isolates) indicated long-term population growth, with negatively skewed allele frequency distributions (genome-wide average Tajima’s D = -1.35). Against this background there was evidence of balancing selection on particular genes, including the circumsporozoite protein (csp gene had the top value of Tajima’s D = 1.57), and scans of haplotype homozygosity implicate several genomic regions to be under recent positive selection.
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spelling unimas-102502017-02-23T01:40:52Z http://ir.unimas.my/id/eprint/10250/ Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi Assefa, S. Lim, C. Preston, M.D. Duffy, C.W. Nair, M.B. Adroub, S.A. Kadir, K.A. Goldberg, J.M. Neafsey, D.E. Divis, Paul Cliff Simon Clark, T.G. Duraisingh, M.T. Conway, D.J. Pain, A. Singh, B. Q Science (General) QR Microbiology Malaria cases due to the zoonotic parasite P. knowlesi are being increasingly reported throughout Southeast Asia and in travelers returning from the region. To test for evidence of signatures of selection or unusual population structure in this parasite, we surveyed genome sequence diversity in 48 clinical isolates recently sampled from Malaysian Borneo and 5 lines maintained in laboratory rhesus macaques after isolation in the 1960s from Peninsular Malaysia and the Philippines. Overall genome-wide nucleotide diversity (π = 6.03 x 10-3) was much higher than has been seen in worldwide samples of either of the major endemic malaria parasite species P. falciparum and P. vivax. A remarkable substructure is revealed within P. knowlesi, consisting of two major sympatric clusters of the clinical isolates, and a third cluster comprising the laboratory isolates. There was deep differentiation between the two clusters of clinical isolates (mean genome-wide FST = 0.21, with 9,293 SNPs having fixed differences of FST = 1.0). This showed marked heterogeneity across the genome, mean FST values of different chromosomes ranging from 0.08 to 0.34, with further significant variation across regions within several chromosomes. Analysis of the largest cluster (Cluster 1, 38 isolates) indicated long-term population growth, with negatively skewed allele frequency distributions (genome-wide average Tajima’s D = -1.35). Against this background there was evidence of balancing selection on particular genes, including the circumsporozoite protein (csp gene had the top value of Tajima’s D = 1.57), and scans of haplotype homozygosity implicate several genomic regions to be under recent positive selection. Proceedings of the National Academy 2015-10-20 Article PeerReviewed text en http://ir.unimas.my/id/eprint/10250/1/2015_PNAS_PkGenomeFinal.pdf Assefa, S. and Lim, C. and Preston, M.D. and Duffy, C.W. and Nair, M.B. and Adroub, S.A. and Kadir, K.A. and Goldberg, J.M. and Neafsey, D.E. and Divis, Paul Cliff Simon and Clark, T.G. and Duraisingh, M.T. and Conway, D.J. and Pain, A. and Singh, B. (2015) Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi. Proceedings of the National Academy of Sciences USA, 112 (42). pp. 13027-13032. ISSN 1091-6490 http://www.scopus.com/inward/record.url?eid=2-s2.0-84947207193&partnerID=40&md5=8f2eddd4285a03c50f936ec10b21f488 doi: 10.1073/pnas.1509534112
spellingShingle Q Science (General)
QR Microbiology
Assefa, S.
Lim, C.
Preston, M.D.
Duffy, C.W.
Nair, M.B.
Adroub, S.A.
Kadir, K.A.
Goldberg, J.M.
Neafsey, D.E.
Divis, Paul Cliff Simon
Clark, T.G.
Duraisingh, M.T.
Conway, D.J.
Pain, A.
Singh, B.
Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title_full Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title_fullStr Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title_full_unstemmed Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title_short Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi
title_sort population genomic structure and adaptation in the zoonotic malaria parasite plasmodium knowlesi
topic Q Science (General)
QR Microbiology
url http://ir.unimas.my/id/eprint/10250/
http://ir.unimas.my/id/eprint/10250/
http://ir.unimas.my/id/eprint/10250/
http://ir.unimas.my/id/eprint/10250/1/2015_PNAS_PkGenomeFinal.pdf