Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus
Background: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Parasites & Vectors
2012
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| Online Access: | http://ir.unimas.my/id/eprint/10246/ http://ir.unimas.my/id/eprint/10246/1/Elevation%20of%20dopamine%20level%20reduces%20host-seeking%20activity%20in%20the%20adult%20female%20mosquito%20Aedes%20albopictus%20%28abstract%29.pdf |
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| author | Yuki, Fukumitsu Keiichi, Irie Tomomitsu, Satho Hitoshi, Aonuma Hamady, Dieng Abu Hassan, Ahmad Yukihiko, Nakashima Kenichi, Mishima Nobuhiro, Kashige Fumio, Miake |
| author_facet | Yuki, Fukumitsu Keiichi, Irie Tomomitsu, Satho Hitoshi, Aonuma Hamady, Dieng Abu Hassan, Ahmad Yukihiko, Nakashima Kenichi, Mishima Nobuhiro, Kashige Fumio, Miake |
| author_sort | Yuki, Fukumitsu |
| building | UNIMAS Institutional Repository |
| collection | Online Access |
| description | Background: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female
mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent
virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in
the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female
mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it
remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this
study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult
female mosquito Aedes albopictus (Ae. albopictus).
Findings: We compared host-seeking behavior in one group of emerging female adults treated with
L-β-3,4-dihydroxyphenylalanine (L-DOPA), the precursor of DA, (L-DOPA group), with that in an untreated
control (control group) after confirming elevation of head DA in L-DOPA group by using high-performance
liquid chromatography. The content of head DA in L-DOPA group significantly remained higher than that in
controls on all days examined. The host-seeking activity in the control group showed a gradual increase over
the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the
L-DOPA group. Therefore, the host-seeking activity of L-DOPA group was significantly lower than that of the
controls between day 3 and 6 post-emergence.
Conclusion: Our results indicate that elevation of DA level reduces host-seeking activity in adult female
mosquito Ae. albopictus. |
| first_indexed | 2025-11-15T06:28:35Z |
| format | Article |
| id | unimas-10246 |
| institution | Universiti Malaysia Sarawak |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T06:28:35Z |
| publishDate | 2012 |
| publisher | Parasites & Vectors |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | unimas-102462016-01-19T02:26:47Z http://ir.unimas.my/id/eprint/10246/ Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus Yuki, Fukumitsu Keiichi, Irie Tomomitsu, Satho Hitoshi, Aonuma Hamady, Dieng Abu Hassan, Ahmad Yukihiko, Nakashima Kenichi, Mishima Nobuhiro, Kashige Fumio, Miake SF Animal culture Background: Mosquito-borne viruses are transmitted to human hosts via blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult female mosquito Aedes albopictus (Ae. albopictus). Findings: We compared host-seeking behavior in one group of emerging female adults treated with L-β-3,4-dihydroxyphenylalanine (L-DOPA), the precursor of DA, (L-DOPA group), with that in an untreated control (control group) after confirming elevation of head DA in L-DOPA group by using high-performance liquid chromatography. The content of head DA in L-DOPA group significantly remained higher than that in controls on all days examined. The host-seeking activity in the control group showed a gradual increase over the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the L-DOPA group. Therefore, the host-seeking activity of L-DOPA group was significantly lower than that of the controls between day 3 and 6 post-emergence. Conclusion: Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito Ae. albopictus. Parasites & Vectors 2012 Article NonPeerReviewed text en http://ir.unimas.my/id/eprint/10246/1/Elevation%20of%20dopamine%20level%20reduces%20host-seeking%20activity%20in%20the%20adult%20female%20mosquito%20Aedes%20albopictus%20%28abstract%29.pdf Yuki, Fukumitsu and Keiichi, Irie and Tomomitsu, Satho and Hitoshi, Aonuma and Hamady, Dieng and Abu Hassan, Ahmad and Yukihiko, Nakashima and Kenichi, Mishima and Nobuhiro, Kashige and Fumio, Miake (2012) Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus. Parasites & Vectors, 5 (1). ISSN 1756-3305 https://www.researchgate.net/publication/224938134_Elevation_of_dopamine_level_reduces_host-seeking_activity_in_the_adult_female_mosquito_Aedes_albopictus DOI: 10.1186/1756-3305-5-92 |
| spellingShingle | SF Animal culture Yuki, Fukumitsu Keiichi, Irie Tomomitsu, Satho Hitoshi, Aonuma Hamady, Dieng Abu Hassan, Ahmad Yukihiko, Nakashima Kenichi, Mishima Nobuhiro, Kashige Fumio, Miake Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title | Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title_full | Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title_fullStr | Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title_full_unstemmed | Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title_short | Elevation of dopamine level reduces hostseeking activity in the adult female mosquito Aedes albopictus |
| title_sort | elevation of dopamine level reduces hostseeking activity in the adult female mosquito aedes albopictus |
| topic | SF Animal culture |
| url | http://ir.unimas.my/id/eprint/10246/ http://ir.unimas.my/id/eprint/10246/ http://ir.unimas.my/id/eprint/10246/ http://ir.unimas.my/id/eprint/10246/1/Elevation%20of%20dopamine%20level%20reduces%20host-seeking%20activity%20in%20the%20adult%20female%20mosquito%20Aedes%20albopictus%20%28abstract%29.pdf |