Solid phase transformation and stability of carbamazepine-saccharin co-crystal
Formulation of drug products is a multidisciplinary field, with pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought this research possibility to pr...
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| Format: | Undergraduates Project Papers |
| Language: | English |
| Published: |
2012
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| Online Access: | http://umpir.ump.edu.my/id/eprint/7121/ http://umpir.ump.edu.my/id/eprint/7121/1/NAZRUL_SHAFEEQ_BIN_SHAHADAN.PDF |
| _version_ | 1848817932637831168 |
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| author | Nazrul Shafeeq, Shahadan |
| author_facet | Nazrul Shafeeq, Shahadan |
| author_sort | Nazrul Shafeeq, Shahadan |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Formulation of drug products is a multidisciplinary field, with pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought this research possibility to produce pharmaceutical materials by crystallization design. This research is conducted to determine the character by both physical and chemical properties beside to determine the solubility of Carbamazepine and Saccharin. It is started by determine the co-crystal solubility of Carbamazepine and. Saccharin by applying the different concentration and temperature of Carbamazepine and Saccharin solution by following gravimetric method. It is proceed by determine the characterization of solution by screening using FTIIR, TGA and DSC to get morphology, melting point, weight loss and wavelength. The final discussion after result finding, it can be concluding that concentration and temperature are the main factor to control the solubility of Carbamazepine and Saccharin co-crystal. By using the solubility that was obtained from the gravimetric method, the characterization process of both Carbamazepine and Saccharin are also conclude by their own properties. As an additional conclusion, solid state form of active pharmaceutical ingredients (APIs), cocrystals not only offer a tool for tailoring physicochemical properties, but also create new opportunities for the research-based pharmaceutical companies to address intellectual property (IP) protection issues. |
| first_indexed | 2025-11-15T01:29:38Z |
| format | Undergraduates Project Papers |
| id | ump-7121 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:29:38Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-71212021-06-03T04:57:01Z http://umpir.ump.edu.my/id/eprint/7121/ Solid phase transformation and stability of carbamazepine-saccharin co-crystal Nazrul Shafeeq, Shahadan TP Chemical technology Formulation of drug products is a multidisciplinary field, with pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought this research possibility to produce pharmaceutical materials by crystallization design. This research is conducted to determine the character by both physical and chemical properties beside to determine the solubility of Carbamazepine and Saccharin. It is started by determine the co-crystal solubility of Carbamazepine and. Saccharin by applying the different concentration and temperature of Carbamazepine and Saccharin solution by following gravimetric method. It is proceed by determine the characterization of solution by screening using FTIIR, TGA and DSC to get morphology, melting point, weight loss and wavelength. The final discussion after result finding, it can be concluding that concentration and temperature are the main factor to control the solubility of Carbamazepine and Saccharin co-crystal. By using the solubility that was obtained from the gravimetric method, the characterization process of both Carbamazepine and Saccharin are also conclude by their own properties. As an additional conclusion, solid state form of active pharmaceutical ingredients (APIs), cocrystals not only offer a tool for tailoring physicochemical properties, but also create new opportunities for the research-based pharmaceutical companies to address intellectual property (IP) protection issues. 2012-07 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7121/1/NAZRUL_SHAFEEQ_BIN_SHAHADAN.PDF Nazrul Shafeeq, Shahadan (2012) Solid phase transformation and stability of carbamazepine-saccharin co-crystal. Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang. |
| spellingShingle | TP Chemical technology Nazrul Shafeeq, Shahadan Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title | Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title_full | Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title_fullStr | Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title_full_unstemmed | Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title_short | Solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| title_sort | solid phase transformation and stability of carbamazepine-saccharin co-crystal |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/7121/ http://umpir.ump.edu.my/id/eprint/7121/1/NAZRUL_SHAFEEQ_BIN_SHAHADAN.PDF |