Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal
Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetr...
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| Format: | Undergraduates Project Papers |
| Language: | English |
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2012
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| Online Access: | http://umpir.ump.edu.my/id/eprint/7117/ http://umpir.ump.edu.my/id/eprint/7117/1/CD7170.pdf |
| _version_ | 1848817931545214976 |
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| author | Mohd Rohaizam, Mohd Sidek |
| author_facet | Mohd Rohaizam, Mohd Sidek |
| author_sort | Mohd Rohaizam, Mohd Sidek |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future. |
| first_indexed | 2025-11-15T01:29:36Z |
| format | Undergraduates Project Papers |
| id | ump-7117 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:29:36Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-71172021-06-03T04:57:51Z http://umpir.ump.edu.my/id/eprint/7117/ Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal Mohd Rohaizam, Mohd Sidek TP Chemical technology Co-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future. 2012-07 Undergraduates Project Papers NonPeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/7117/1/CD7170.pdf Mohd Rohaizam, Mohd Sidek (2012) Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal. Faculty of Chemical and Natural Resources Engineering, Universiti Malaysia Pahang. |
| spellingShingle | TP Chemical technology Mohd Rohaizam, Mohd Sidek Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title | Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title_full | Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title_fullStr | Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title_full_unstemmed | Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title_short | Solid Phase Transformation and Stability of Carbamazepine-adipic Acid Co-Crystal |
| title_sort | solid phase transformation and stability of carbamazepine-adipic acid co-crystal |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/7117/ http://umpir.ump.edu.my/id/eprint/7117/1/CD7170.pdf |