Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents
Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures f...
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ACS Publications
2013
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| Online Access: | http://umpir.ump.edu.my/id/eprint/6219/ |
| _version_ | 1848817723615739904 |
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| author | Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam |
| author_facet | Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam |
| author_sort | Siti Kholijah, Abdul Mudalip |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Different classes of solvents provide different polarity
values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents(N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water. |
| first_indexed | 2025-11-15T01:26:18Z |
| format | Article |
| id | ump-6219 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| last_indexed | 2025-11-15T01:26:18Z |
| publishDate | 2013 |
| publisher | ACS Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-62192018-02-05T03:04:33Z http://umpir.ump.edu.my/id/eprint/6219/ Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam TP Chemical technology Different classes of solvents provide different polarity values, which influence the solubility of pharmaceutical solids. In this article, the solubility of mefenamic acid in different classes of organic solvents, including polar protic, dipolar aprotic, and apolar aprotics at a range of temperatures from (298 to 323) K are reported. It has been found that mefenamic acid shows high solubility in dipolar aprotic solvents(N,N-dimethylacetamide, N,N-dimethylformamide, ethyl acetate, and propanone), moderate solubility in polar protic solvents (ethanol and propan-2-ol), and poor solubility in apolar aprotic solvents (hexane, heptane, and cyclohexane) and water. ACS Publications 2013 Article PeerReviewed Siti Kholijah, Abdul Mudalip and Mohd R., Abu Bakar and Parveen, Jamal and Fatmawati, Adam (2013) Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents. Journal of Chemical & Engineering Data, 58 (12). pp. 3447-3452. ISSN 0021-9568. (Published) http://dx.doi.org/10.1021/je400714f DOI: 10.1021/je400714f |
| spellingShingle | TP Chemical technology Siti Kholijah, Abdul Mudalip Mohd R., Abu Bakar Parveen, Jamal Fatmawati, Adam Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title | Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title_full | Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title_fullStr | Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title_full_unstemmed | Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title_short | Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents |
| title_sort | solubility and dissolution thermodynamic data of mefenamic acid crystals in different classes of organic solvents |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/ http://umpir.ump.edu.my/id/eprint/6219/ |