Product optimization of a fed-batch fermentation process
This paper discusses the development of constrained optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2007
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| Online Access: | http://umpir.ump.edu.my/id/eprint/6218/ http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf |
| _version_ | 1848817723313750016 |
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| author | Arshad, Ahmad Noor Asma Fazli, Abdul Samad Mohd Kamaruddin, Abd Hamid |
| author_facet | Arshad, Ahmad Noor Asma Fazli, Abdul Samad Mohd Kamaruddin, Abd Hamid |
| author_sort | Arshad, Ahmad |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | This paper discusses the development of constrained optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process. |
| first_indexed | 2025-11-15T01:26:18Z |
| format | Conference or Workshop Item |
| id | ump-6218 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T01:26:18Z |
| publishDate | 2007 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-62182025-02-04T07:28:12Z http://umpir.ump.edu.my/id/eprint/6218/ Product optimization of a fed-batch fermentation process Arshad, Ahmad Noor Asma Fazli, Abdul Samad Mohd Kamaruddin, Abd Hamid QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology This paper discusses the development of constrained optimization strategies for a fed-batch penicillin fermentation process. To facilitate the study, a mathematical model of the system is developed based on published materials, and simulated using MATLAB software. Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. Using these estimates, good control of product concentration is established thus enabling it to be implemented as part of product concentration control loop. Further improvements are introduced using dynamic optimization aiming at increasing the achievable product concentration while satisfying all process constraints. Two strategies are considered. These are optimal control policy using direct-shooting algorithm and unconstrained Dynamic Matrix Control (DMC). From this two optimization approaches, it is possible to estimate the optimal operating conditions as substrate feed rate so that the systems presents high performance within threshold value limit. The result also revealed that the use of DMC approach is superior the direct shooting method in term of the penicillin concentration as well as penicillin purity. Results obtained in this study have exposed the potentials of dynamic optimization schemes in improving the product purity in a fed-batch fermentation process. 2007 Conference or Workshop Item PeerReviewed application/pdf en http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf Arshad, Ahmad and Noor Asma Fazli, Abdul Samad and Mohd Kamaruddin, Abd Hamid (2007) Product optimization of a fed-batch fermentation process. In: Proceedings of European Congress of Chemical Engineering (ECCE-6). Proceedings of European Congress of Chemical Engineering (ECCE-6) , 16-20 September 2007 , Copenhagen. pp. 1-17.. (Published) |
| spellingShingle | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Arshad, Ahmad Noor Asma Fazli, Abdul Samad Mohd Kamaruddin, Abd Hamid Product optimization of a fed-batch fermentation process |
| title | Product optimization of a fed-batch fermentation process |
| title_full | Product optimization of a fed-batch fermentation process |
| title_fullStr | Product optimization of a fed-batch fermentation process |
| title_full_unstemmed | Product optimization of a fed-batch fermentation process |
| title_short | Product optimization of a fed-batch fermentation process |
| title_sort | product optimization of a fed-batch fermentation process |
| topic | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/6218/ http://umpir.ump.edu.my/id/eprint/6218/1/fkksa-2007_proceeding.pdf |