Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer
Breast cancer is a prominent cause of death in women, highlighting the need for new therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally been used for its anti-inflammatory and antioxidant effects, may contain bioactive chemicals that can help treat cancer. The...
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| Format: | Undergraduates Project Papers |
| Language: | English |
| Published: |
2025
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| Online Access: | https://umpir.ump.edu.my/id/eprint/45705/ |
| _version_ | 1848827490044215296 |
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| author | P’ng, Zhe Hung |
| author_facet | P’ng, Zhe Hung |
| author_sort | P’ng, Zhe Hung |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Breast cancer is a prominent cause of death in women, highlighting the need for new therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally been used for its anti-inflammatory and antioxidant effects, may contain bioactive chemicals that can help treat cancer. The anticancer efficacy of C. vespertilionis leaf extracts on MCF-7 breast cancer cells were investigated in vitro using Dichloromethane (DCM) and butanol as solvents. GC-MS study discovered bioactive substances with anticancer and antioxidant effects, including Phytol, 6-tert-Butyl-2,4-dimethylphenol, and n-Hexadecanoic acid. The DCM extract had a higher flavonoid content (0.5435 mg QE/mL), but the butanol extract had a higher phenolic (0.4 mg GAE/mL) and tannin content (0.09071 mg TAE/mL). Cytotoxicity studies revealed dose-dependent effects, with IC50 values of 279.64 µg/mL (DCM) and 269.77 µg/mL (butanol). Apoptotic morphological changes were seen in treated cells. These findings indicate that C. vespertilionis leaf extracts are a potential source of natural anticancer chemicals. |
| first_indexed | 2025-11-15T04:01:32Z |
| format | Undergraduates Project Papers |
| id | ump-45705 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T04:01:32Z |
| publishDate | 2025 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-457052025-10-02T07:12:51Z https://umpir.ump.edu.my/id/eprint/45705/ Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer P’ng, Zhe Hung HD Industries. Land use. Labor T Technology (General) Breast cancer is a prominent cause of death in women, highlighting the need for new therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally been used for its anti-inflammatory and antioxidant effects, may contain bioactive chemicals that can help treat cancer. The anticancer efficacy of C. vespertilionis leaf extracts on MCF-7 breast cancer cells were investigated in vitro using Dichloromethane (DCM) and butanol as solvents. GC-MS study discovered bioactive substances with anticancer and antioxidant effects, including Phytol, 6-tert-Butyl-2,4-dimethylphenol, and n-Hexadecanoic acid. The DCM extract had a higher flavonoid content (0.5435 mg QE/mL), but the butanol extract had a higher phenolic (0.4 mg GAE/mL) and tannin content (0.09071 mg TAE/mL). Cytotoxicity studies revealed dose-dependent effects, with IC50 values of 279.64 µg/mL (DCM) and 269.77 µg/mL (butanol). Apoptotic morphological changes were seen in treated cells. These findings indicate that C. vespertilionis leaf extracts are a potential source of natural anticancer chemicals. 2025-02 Undergraduates Project Papers NonPeerReviewed pdf en https://umpir.ump.edu.my/id/eprint/45705/1/Evaluation%20of%20anticancer%20activities%20of%20chistia%20vespertilionis%20%28red%20butterfly%20wing%29%20on%20breast%20cancer.pdf P’ng, Zhe Hung (2025) Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer. Faculty of Industrial Sciences and Technology, Universti Malaysia Pahang Al-Sultan Abdullah. |
| spellingShingle | HD Industries. Land use. Labor T Technology (General) P’ng, Zhe Hung Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title | Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title_full | Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title_fullStr | Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title_full_unstemmed | Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title_short | Evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| title_sort | evaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer |
| topic | HD Industries. Land use. Labor T Technology (General) |
| url | https://umpir.ump.edu.my/id/eprint/45705/ |