| Summary: | Breast cancer is a prominent cause of death in women, highlighting the need for new therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally been used for its anti-inflammatory and antioxidant effects, may contain bioactive chemicals that can help treat cancer. The anticancer efficacy of C. vespertilionis leaf extracts on MCF-7 breast cancer cells were investigated in vitro using Dichloromethane (DCM) and butanol as solvents. GC-MS study discovered bioactive substances with anticancer and antioxidant effects, including Phytol, 6-tert-Butyl-2,4-dimethylphenol, and n-Hexadecanoic acid. The DCM extract had a higher flavonoid content (0.5435 mg QE/mL), but the butanol extract had a higher phenolic (0.4 mg GAE/mL) and tannin content (0.09071 mg TAE/mL). Cytotoxicity studies revealed dose-dependent effects, with IC50 values of 279.64 µg/mL (DCM) and 269.77 µg/mL (butanol). Apoptotic morphological changes were seen in treated cells. These findings indicate that C. vespertilionis leaf extracts are a potential source of natural anticancer chemicals.
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