Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals
Previous research utilising diffusion tensor imaging (DTI) has reported disruptions in white matter pathways among individuals with anxiety-related disorders. However, there is limited research focusing on healthy or non-clinical groups with self-reported anxiety symptoms. This investigation aims to...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universiti Sultan Zainal Abidin
2025
|
| Subjects: | |
| Online Access: | https://umpir.ump.edu.my/id/eprint/45561/ |
| _version_ | 1848827450974273536 |
|---|---|
| author | Wan Adibah Nadiah, Abd Razak Rajeev Shamsuddin, Perisamy Che Mohd Nasril, Che Mohd Nassir Muzaimi, Mustapha Mohd Khairul Izamil, Zolkefley |
| author_facet | Wan Adibah Nadiah, Abd Razak Rajeev Shamsuddin, Perisamy Che Mohd Nasril, Che Mohd Nassir Muzaimi, Mustapha Mohd Khairul Izamil, Zolkefley |
| author_sort | Wan Adibah Nadiah, Abd Razak |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Previous research utilising diffusion tensor imaging (DTI) has reported disruptions in white matter pathways among individuals with anxiety-related disorders. However, there is limited research focusing on healthy or non-clinical groups with self-reported anxiety symptoms. This investigation aims to explore how self- reported anxiety relates to white matter microstructural differences in non-clinical adult brains. A total of twenty-nine participants took part in the study. Each participant completed the Depression Anxiety Stress Scale-21 (DASS-21) and underwent a detailed high-resolution 3T magnetic resonance imaging (MRI). Diffusion MRI connectometry was conducted to generate correlational tractography, identifying links between generalised fractional anisotropy (FA) values of white matter and anxiety scores derived from the DASS-21. The average anxiety score, as measured by the DASS-21, was 10.97 with a standard deviation of 7.002. Notably, a significant inverse association emerged between anxiety levels and FA values in several white matter regions, including the left and right inferior fronto-occipital fasciculi, the left inferior longitudinal fasciculus, the right superior longitudinal fasciculus, and the left parahippocampal cingulum bundle (p < 0.05). The local brain connectome associated with anxiety may serve as a biomarker for early diagnosis and prevention of anxiety disorders in non-clinical populations. |
| first_indexed | 2025-11-15T04:00:55Z |
| format | Article |
| id | ump-45561 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T04:00:55Z |
| publishDate | 2025 |
| publisher | Universiti Sultan Zainal Abidin |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-455612025-09-12T07:29:33Z https://umpir.ump.edu.my/id/eprint/45561/ Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals Wan Adibah Nadiah, Abd Razak Rajeev Shamsuddin, Perisamy Che Mohd Nasril, Che Mohd Nassir Muzaimi, Mustapha Mohd Khairul Izamil, Zolkefley RA0421 Public health. Hygiene. Preventive Medicine RC Internal medicine Previous research utilising diffusion tensor imaging (DTI) has reported disruptions in white matter pathways among individuals with anxiety-related disorders. However, there is limited research focusing on healthy or non-clinical groups with self-reported anxiety symptoms. This investigation aims to explore how self- reported anxiety relates to white matter microstructural differences in non-clinical adult brains. A total of twenty-nine participants took part in the study. Each participant completed the Depression Anxiety Stress Scale-21 (DASS-21) and underwent a detailed high-resolution 3T magnetic resonance imaging (MRI). Diffusion MRI connectometry was conducted to generate correlational tractography, identifying links between generalised fractional anisotropy (FA) values of white matter and anxiety scores derived from the DASS-21. The average anxiety score, as measured by the DASS-21, was 10.97 with a standard deviation of 7.002. Notably, a significant inverse association emerged between anxiety levels and FA values in several white matter regions, including the left and right inferior fronto-occipital fasciculi, the left inferior longitudinal fasciculus, the right superior longitudinal fasciculus, and the left parahippocampal cingulum bundle (p < 0.05). The local brain connectome associated with anxiety may serve as a biomarker for early diagnosis and prevention of anxiety disorders in non-clinical populations. Universiti Sultan Zainal Abidin 2025-04-29 Article PeerReviewed pdf en https://umpir.ump.edu.my/id/eprint/45561/1/742-Article%20Text-3423-1-10-20250429.pdf Wan Adibah Nadiah, Abd Razak and Rajeev Shamsuddin, Perisamy and Che Mohd Nasril, Che Mohd Nassir and Muzaimi, Mustapha and Mohd Khairul Izamil, Zolkefley (2025) Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals. Asian People Journal, 8 (1). pp. 181-195. ISSN 2600-8971. (Published) https://doi.org/10.37231/apj.2025.8.1.742 https://doi.org/10.37231/apj.2025.8.1.742 https://doi.org/10.37231/apj.2025.8.1.742 |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine RC Internal medicine Wan Adibah Nadiah, Abd Razak Rajeev Shamsuddin, Perisamy Che Mohd Nasril, Che Mohd Nassir Muzaimi, Mustapha Mohd Khairul Izamil, Zolkefley Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title | Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title_full | Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title_fullStr | Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title_full_unstemmed | Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title_short | Exploring brain changes in self-reported anxiety: Cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| title_sort | exploring brain changes in self-reported anxiety: cutting-edge exploratory diffusion tensor imaging study reveals distinct alterations in white matter tract structure among non-clinical individuals |
| topic | RA0421 Public health. Hygiene. Preventive Medicine RC Internal medicine |
| url | https://umpir.ump.edu.my/id/eprint/45561/ https://umpir.ump.edu.my/id/eprint/45561/ https://umpir.ump.edu.my/id/eprint/45561/ |