Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy
Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8)....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2025
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| Online Access: | https://umpir.ump.edu.my/id/eprint/45377/ |
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| author | Gaayatri, Silvaraju Nur Airin Syahira, Johari Azren Aida, Asmawi Rosniza, Razali Fatmawati, Adam Loo, Yan Shan Nurul Akmarina, Mohd Abdul Kamal |
| author_facet | Gaayatri, Silvaraju Nur Airin Syahira, Johari Azren Aida, Asmawi Rosniza, Razali Fatmawati, Adam Loo, Yan Shan Nurul Akmarina, Mohd Abdul Kamal |
| author_sort | Gaayatri, Silvaraju |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC50 = 21.5 ± 3.8 µg mL−1), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells. |
| first_indexed | 2025-11-15T04:00:08Z |
| format | Article |
| id | ump-45377 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T04:00:08Z |
| publishDate | 2025 |
| publisher | Springer Nature |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-453772025-08-13T07:16:53Z https://umpir.ump.edu.my/id/eprint/45377/ Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy Gaayatri, Silvaraju Nur Airin Syahira, Johari Azren Aida, Asmawi Rosniza, Razali Fatmawati, Adam Loo, Yan Shan Nurul Akmarina, Mohd Abdul Kamal RM Therapeutics. Pharmacology Effective breast cancer chemotherapy is hindered by dose-limiting systemic toxicity and off-target effects of conventional chemotherapeutics. Here we report a one-pot, surfactant-free solvothermal synthesis of hyaluronic acid-functionalized Zeolitic Imidazolate Framework-8 nanoparticles (HA@nZIF-8). The physicochemical properties of both functionalized and non-functionalized nanoparticles were characterized using characterization techniques, including powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), scanning electron microscopy (SEM), nitrogen adsorption–desorption isotherms, and thermogravimetric analysis (TGA). SEM measured well-dispersed nanoparticles (93.5 ± 14.4 nm), whereas HR-TEM gave an average size of 127.3 ± 18.9 nm. Brunauer–Emmett–Teller (BET) surface area was reduced by 30%, corresponding to a successful surface functionalization. The HA@nZIF-8 demonstrates inhibitory effects within human breast cancer cells, MCF-7 (IC50 = 21.5 ± 3.8 µg mL−1), and is selectively toxic towards cancer cells with a selectivity index (SI) of 3.8. This work indicates that surface functionalization of ZIF-8 using hyaluronic acid (HA) promotes promising in vitro cytotoxic effects with selective activity toward MCF-7 cells. Springer Nature 2025-08-05 Article PeerReviewed pdf en cc_by_nc_nd_4 https://umpir.ump.edu.my/id/eprint/45377/1/Original%20article%20-%20HA-ZIF-8.pdf Gaayatri, Silvaraju and Nur Airin Syahira, Johari and Azren Aida, Asmawi and Rosniza, Razali and Fatmawati, Adam and Loo, Yan Shan and Nurul Akmarina, Mohd Abdul Kamal (2025) Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy. Hyaluronic acid‑functionalized zeolitic imidazolate framework‑8 nanoparticles: a one‑pot synthesis approach for breast cancer therapy, 27 (215). pp. 1-15. ISSN 1572-896X. (Published) (Preface) https://doi.org/10.1007/s11051-025-06412-0 https://doi.org/10.1007/s11051-025-06412-0 https://doi.org/10.1007/s11051-025-06412-0 |
| spellingShingle | RM Therapeutics. Pharmacology Gaayatri, Silvaraju Nur Airin Syahira, Johari Azren Aida, Asmawi Rosniza, Razali Fatmawati, Adam Loo, Yan Shan Nurul Akmarina, Mohd Abdul Kamal Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title | Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title_full | Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title_fullStr | Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title_full_unstemmed | Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title_short | Hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: A one-pot synthesis approach for breast cancer therapy |
| title_sort | hyaluronic acid-functionalized zeolitic imidazolate framework-8 nanoparticles: a one-pot synthesis approach for breast cancer therapy |
| topic | RM Therapeutics. Pharmacology |
| url | https://umpir.ump.edu.my/id/eprint/45377/ https://umpir.ump.edu.my/id/eprint/45377/ https://umpir.ump.edu.my/id/eprint/45377/ |