Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system
Conventional drug delivery systems face challenges like low bioavailability, rapid degradation and limited effectiveness in drug delivery, especially for persistent infections. Our research focus to develop nanofiber drug delivery systems (NDDSs) using biopolymers like starch and gelatine. In this s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Trans Tech Publications, Switzerland
2025
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| Online Access: | https://umpir.ump.edu.my/id/eprint/45259/ |
| _version_ | 1848827368043446272 |
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| author | Ayuni Nazurah, Salim Salmi Norhayati, Abdullah Noryn Haniz, Sa’adin Nur Amirah, Mohamed Salpini Syed, Murtaza Haider |
| author_facet | Ayuni Nazurah, Salim Salmi Norhayati, Abdullah Noryn Haniz, Sa’adin Nur Amirah, Mohamed Salpini Syed, Murtaza Haider |
| author_sort | Ayuni Nazurah, Salim Salmi |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Conventional drug delivery systems face challenges like low bioavailability, rapid degradation and limited effectiveness in drug delivery, especially for persistent infections. Our research focus to develop nanofiber drug delivery systems (NDDSs) using biopolymers like starch and gelatine. In this study, nanofilm was produced using polylactic acid (PLA), Nanocrystalline Cellulose (NCC), gelatine/starch, and paracetamol (acetaminophen) as the drug at different ratios. From SEM, the best ratio for gelatine-based nanofilm was 6% PLA: 0.5% gelatine : 0.15% NCC : 0.02% drug while starch-based nanofilm the best ratio was 8% PLA: 0.2% starch: 0.15% NCC: 0.02% drug. In drug release kinetics study, the results were compared using mathematical models such as zero order, first order, and Higuchi models for both types of bio-based nanofilm. The drug release kinetics results indicate that the starch-based nanofilm was superior to the gelatin-based nanofilm in drug delivery, fitting both the Higuchi and Zero-order models. |
| first_indexed | 2025-11-15T03:59:36Z |
| format | Article |
| id | ump-45259 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:59:36Z |
| publishDate | 2025 |
| publisher | Trans Tech Publications, Switzerland |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-452592025-08-06T01:31:23Z https://umpir.ump.edu.my/id/eprint/45259/ Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system Ayuni Nazurah, Salim Salmi Norhayati, Abdullah Noryn Haniz, Sa’adin Nur Amirah, Mohamed Salpini Syed, Murtaza Haider RM Therapeutics. Pharmacology T Technology (General) TP Chemical technology Conventional drug delivery systems face challenges like low bioavailability, rapid degradation and limited effectiveness in drug delivery, especially for persistent infections. Our research focus to develop nanofiber drug delivery systems (NDDSs) using biopolymers like starch and gelatine. In this study, nanofilm was produced using polylactic acid (PLA), Nanocrystalline Cellulose (NCC), gelatine/starch, and paracetamol (acetaminophen) as the drug at different ratios. From SEM, the best ratio for gelatine-based nanofilm was 6% PLA: 0.5% gelatine : 0.15% NCC : 0.02% drug while starch-based nanofilm the best ratio was 8% PLA: 0.2% starch: 0.15% NCC: 0.02% drug. In drug release kinetics study, the results were compared using mathematical models such as zero order, first order, and Higuchi models for both types of bio-based nanofilm. The drug release kinetics results indicate that the starch-based nanofilm was superior to the gelatin-based nanofilm in drug delivery, fitting both the Higuchi and Zero-order models. Trans Tech Publications, Switzerland 2025-06 Article PeerReviewed pdf en https://umpir.ump.edu.my/id/eprint/45259/1/Development%20and%20Kinetic%20Evaluation%20of%20PLA_NCC%20Nanofilms.pdf Ayuni Nazurah, Salim Salmi and Norhayati, Abdullah and Noryn Haniz, Sa’adin and Nur Amirah, Mohamed Salpini and Syed, Murtaza Haider (2025) Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system. Key Engineering Materials, 1015. pp. 63-67. ISSN 1013-9826 (print); 1662-9795 (online). (Published) https://doi.org/10.4028/p-z3SdUL https://doi.org/10.4028/p-z3SdUL https://doi.org/10.4028/p-z3SdUL |
| spellingShingle | RM Therapeutics. Pharmacology T Technology (General) TP Chemical technology Ayuni Nazurah, Salim Salmi Norhayati, Abdullah Noryn Haniz, Sa’adin Nur Amirah, Mohamed Salpini Syed, Murtaza Haider Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title | Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title_full | Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title_fullStr | Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title_full_unstemmed | Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title_short | Development and kinetic evaluation of PLA/NCC nanofilms: A comparative study of gelatin and starch for effective drug delivery system |
| title_sort | development and kinetic evaluation of pla/ncc nanofilms: a comparative study of gelatin and starch for effective drug delivery system |
| topic | RM Therapeutics. Pharmacology T Technology (General) TP Chemical technology |
| url | https://umpir.ump.edu.my/id/eprint/45259/ https://umpir.ump.edu.my/id/eprint/45259/ https://umpir.ump.edu.my/id/eprint/45259/ |