Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma
Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingua...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Research
2025
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| Online Access: | http://umpir.ump.edu.my/id/eprint/45117/ http://umpir.ump.edu.my/id/eprint/45117/1/Comparison%20of%20rArt%20v%201-based%20sublingual%20and%20subcutaneous%20immunotherapy.pdf |
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| author | Tabynov, Kairat Tailakova, Elmira Rakhmatullayeva, Guliza Bolatbekov, Turlan Lim, Yeow Hong Fomin, Gleb Babayeva, Meruert Valenta, Rudolf Tabynov, Kaissar |
| author_facet | Tabynov, Kairat Tailakova, Elmira Rakhmatullayeva, Guliza Bolatbekov, Turlan Lim, Yeow Hong Fomin, Gleb Babayeva, Meruert Valenta, Rudolf Tabynov, Kaissar |
| author_sort | Tabynov, Kairat |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingual (SLIT) ASIT with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma. BALB/c mice were sensitized with Artemisia vulgaris pollen extract and treated with either rArt v 1-based SCIT adjuvanted with Montanide ISA-51, rArt v 1-based SLIT, an extract-based commercial SLIT vaccine, or PBS. Both rArt v 1-based SCIT and SLIT improved lung pathology and reduced airway reactivity following allergen challenge, with rArt v 1-based SCIT inducing Th1-polarized immune responses marked by increased IFN-γ production and rArt v 1-specific IgG1/IgG2a, while SLIT induced stronger mucosal IgA responses. These findings highlight the therapeutic potential of rArt v 1-based ASIT for mugwort allergy. |
| first_indexed | 2025-11-15T03:57:48Z |
| format | Article |
| id | ump-45117 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:57:48Z |
| publishDate | 2025 |
| publisher | Nature Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-451172025-07-18T07:29:42Z http://umpir.ump.edu.my/id/eprint/45117/ Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma Tabynov, Kairat Tailakova, Elmira Rakhmatullayeva, Guliza Bolatbekov, Turlan Lim, Yeow Hong Fomin, Gleb Babayeva, Meruert Valenta, Rudolf Tabynov, Kaissar QP Physiology RC Internal medicine RM Therapeutics. Pharmacology Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingual (SLIT) ASIT with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma. BALB/c mice were sensitized with Artemisia vulgaris pollen extract and treated with either rArt v 1-based SCIT adjuvanted with Montanide ISA-51, rArt v 1-based SLIT, an extract-based commercial SLIT vaccine, or PBS. Both rArt v 1-based SCIT and SLIT improved lung pathology and reduced airway reactivity following allergen challenge, with rArt v 1-based SCIT inducing Th1-polarized immune responses marked by increased IFN-γ production and rArt v 1-specific IgG1/IgG2a, while SLIT induced stronger mucosal IgA responses. These findings highlight the therapeutic potential of rArt v 1-based ASIT for mugwort allergy. Nature Research 2025 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/45117/1/Comparison%20of%20rArt%20v%201-based%20sublingual%20and%20subcutaneous%20immunotherapy.pdf Tabynov, Kairat and Tailakova, Elmira and Rakhmatullayeva, Guliza and Bolatbekov, Turlan and Lim, Yeow Hong and Fomin, Gleb and Babayeva, Meruert and Valenta, Rudolf and Tabynov, Kaissar (2025) Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma. npj Vaccines, 10 (1). pp. 1-10. ISSN 2059-0105. (Published) https://doi.org/10.1038/s41541-025-01112-1 https://doi.org/10.1038/s41541-025-01112-1 |
| spellingShingle | QP Physiology RC Internal medicine RM Therapeutics. Pharmacology Tabynov, Kairat Tailakova, Elmira Rakhmatullayeva, Guliza Bolatbekov, Turlan Lim, Yeow Hong Fomin, Gleb Babayeva, Meruert Valenta, Rudolf Tabynov, Kaissar Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title | Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title_full | Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title_fullStr | Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title_full_unstemmed | Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title_short | Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| title_sort | comparison of rart v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma |
| topic | QP Physiology RC Internal medicine RM Therapeutics. Pharmacology |
| url | http://umpir.ump.edu.my/id/eprint/45117/ http://umpir.ump.edu.my/id/eprint/45117/ http://umpir.ump.edu.my/id/eprint/45117/ http://umpir.ump.edu.my/id/eprint/45117/1/Comparison%20of%20rArt%20v%201-based%20sublingual%20and%20subcutaneous%20immunotherapy.pdf |