Genome-wide association study of long COVID
Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2025
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| Online Access: | http://umpir.ump.edu.my/id/eprint/44630/ http://umpir.ump.edu.my/id/eprint/44630/2/s41588-025-02100-w.pdf |
| _version_ | 1848827146748821504 |
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| author | Lammi, Vilma Nakanishi, Tomoko Ollila, Hanna M. Zeberg, Hugo Hajar Fauzan, Ahmad |
| author_facet | Lammi, Vilma Nakanishi, Tomoko Ollila, Hanna M. Zeberg, Hugo Hajar Fauzan, Ahmad |
| author_sort | Lammi, Vilma |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. |
| first_indexed | 2025-11-15T03:56:05Z |
| format | Article |
| id | ump-44630 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:56:05Z |
| publishDate | 2025 |
| publisher | Springer Nature |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-446302025-05-29T03:42:58Z http://umpir.ump.edu.my/id/eprint/44630/ Genome-wide association study of long COVID Lammi, Vilma Nakanishi, Tomoko Ollila, Hanna M. Zeberg, Hugo Hajar Fauzan, Ahmad R Medicine (General) Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID. Springer Nature 2025 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/44630/2/s41588-025-02100-w.pdf Lammi, Vilma and Nakanishi, Tomoko and Ollila, Hanna M. and Zeberg, Hugo and Hajar Fauzan, Ahmad (2025) Genome-wide association study of long COVID. Nature Genetics. pp. 1-23. ISSN 1546-1718 (online); 1061-4036 (print). (In Press / Online First) (In Press / Online First) https://doi.org/10.1038/s41588-025-02100-w 10.1038/s41588-025-02100-w |
| spellingShingle | R Medicine (General) Lammi, Vilma Nakanishi, Tomoko Ollila, Hanna M. Zeberg, Hugo Hajar Fauzan, Ahmad Genome-wide association study of long COVID |
| title | Genome-wide association study of long COVID |
| title_full | Genome-wide association study of long COVID |
| title_fullStr | Genome-wide association study of long COVID |
| title_full_unstemmed | Genome-wide association study of long COVID |
| title_short | Genome-wide association study of long COVID |
| title_sort | genome-wide association study of long covid |
| topic | R Medicine (General) |
| url | http://umpir.ump.edu.my/id/eprint/44630/ http://umpir.ump.edu.my/id/eprint/44630/ http://umpir.ump.edu.my/id/eprint/44630/ http://umpir.ump.edu.my/id/eprint/44630/2/s41588-025-02100-w.pdf |