Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency
Ionic liquids (ILs) are gaining interest for their excellent ionic conductivity, thermal stability, and low environmental impact, making them suitable for various electrochemical applications. Beyond conductivity, ILs show promise in biotechnology, especially for bioseparation and the recovery of va...
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media Deutschland GmbH
2025
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| Online Access: | https://umpir.ump.edu.my/id/eprint/44480/ |
| _version_ | 1848827329120305152 |
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| author | Nurul Aliaa, Rahman Wan Mohd Hafizuddin, Wan Yussof Ahmad Salihin, Samsudin Mohamad Azmi, Bustam Roshanida, Abdul Rahman Alamin, Idris |
| author_facet | Nurul Aliaa, Rahman Wan Mohd Hafizuddin, Wan Yussof Ahmad Salihin, Samsudin Mohamad Azmi, Bustam Roshanida, Abdul Rahman Alamin, Idris |
| author_sort | Nurul Aliaa, Rahman |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Ionic liquids (ILs) are gaining interest for their excellent ionic conductivity, thermal stability, and low environmental impact, making them suitable for various electrochemical applications. Beyond conductivity, ILs show promise in biotechnology, especially for bioseparation and the recovery of valuable compounds. Morpholinium-based ILs, particularly morpholinium tetrafuoroborate ([MOR][BF4]), ofer a green solvent alternative for efciently recovering ferulic acid (FA) from mixed culture fermentation due to their low toxicity and minimal interference with microbial processes. This study focuses on optimizing FA recovery using [MOR][BF4] through central composite design (CCD) and evaluating its conductivity with electrical impedance spectroscopy (EIS). Key parameters of inorganic salt concentration, phase ratio, and recovery time were tested for their efects on recovery efciency. Out of 26 experimental runs, the highest FA recovery of 93.12% was achieved with 0.06 M ammonium chloride, a 1:5 phase ratio, and a 45-min recovery time. Validation experiments confrmed recovery rates between 90.35 and 91.57%, with less than 10% error between predicted and actual results. Additionally, electrochemical analysis showed that [MOR][BF4] has a conductivity of 0.324 mS·cm⁻ 1 at room temperature, making it suitable for electrochemical applications, especially as an electrolyte additive. Overall, the use of [MOR][BF4] in bioseparation has shown a promising advancement due to its high efciency in targeting biomolecules such as FA directly from complex media like fermentation broth without the need for pretreatment. |
| first_indexed | 2025-11-15T03:55:33Z |
| format | Article |
| id | ump-44480 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:58:59Z |
| publishDate | 2025 |
| publisher | Springer Science and Business Media Deutschland GmbH |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-444802025-08-21T07:50:06Z https://umpir.ump.edu.my/id/eprint/44480/ Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency Nurul Aliaa, Rahman Wan Mohd Hafizuddin, Wan Yussof Ahmad Salihin, Samsudin Mohamad Azmi, Bustam Roshanida, Abdul Rahman Alamin, Idris HD Industries. Land use. Labor TP Chemical technology Ionic liquids (ILs) are gaining interest for their excellent ionic conductivity, thermal stability, and low environmental impact, making them suitable for various electrochemical applications. Beyond conductivity, ILs show promise in biotechnology, especially for bioseparation and the recovery of valuable compounds. Morpholinium-based ILs, particularly morpholinium tetrafuoroborate ([MOR][BF4]), ofer a green solvent alternative for efciently recovering ferulic acid (FA) from mixed culture fermentation due to their low toxicity and minimal interference with microbial processes. This study focuses on optimizing FA recovery using [MOR][BF4] through central composite design (CCD) and evaluating its conductivity with electrical impedance spectroscopy (EIS). Key parameters of inorganic salt concentration, phase ratio, and recovery time were tested for their efects on recovery efciency. Out of 26 experimental runs, the highest FA recovery of 93.12% was achieved with 0.06 M ammonium chloride, a 1:5 phase ratio, and a 45-min recovery time. Validation experiments confrmed recovery rates between 90.35 and 91.57%, with less than 10% error between predicted and actual results. Additionally, electrochemical analysis showed that [MOR][BF4] has a conductivity of 0.324 mS·cm⁻ 1 at room temperature, making it suitable for electrochemical applications, especially as an electrolyte additive. Overall, the use of [MOR][BF4] in bioseparation has shown a promising advancement due to its high efciency in targeting biomolecules such as FA directly from complex media like fermentation broth without the need for pretreatment. Springer Science and Business Media Deutschland GmbH 2025 Article PeerReviewed pdf en https://umpir.ump.edu.my/id/eprint/44480/1/Optimized%20recovery%20of%20ferulic%20acid%20using%20morpholinium.pdf Nurul Aliaa, Rahman and Wan Mohd Hafizuddin, Wan Yussof and Ahmad Salihin, Samsudin and Mohamad Azmi, Bustam and Roshanida, Abdul Rahman and Alamin, Idris (2025) Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency. Ionics (120195). pp. 1-13. ISSN 0947-7047. (Published) https://doi.org/10.1007/s11581-025-06255-8 https://doi.org/10.1007/s11581-025-06255-8 https://doi.org/10.1007/s11581-025-06255-8 |
| spellingShingle | HD Industries. Land use. Labor TP Chemical technology Nurul Aliaa, Rahman Wan Mohd Hafizuddin, Wan Yussof Ahmad Salihin, Samsudin Mohamad Azmi, Bustam Roshanida, Abdul Rahman Alamin, Idris Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title | Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title_full | Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title_fullStr | Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title_full_unstemmed | Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title_short | Optimized recovery of ferulic acid using morpholinium-based ionic liquid: Electrical conduction effects and process efficiency |
| title_sort | optimized recovery of ferulic acid using morpholinium-based ionic liquid: electrical conduction effects and process efficiency |
| topic | HD Industries. Land use. Labor TP Chemical technology |
| url | https://umpir.ump.edu.my/id/eprint/44480/ https://umpir.ump.edu.my/id/eprint/44480/ https://umpir.ump.edu.my/id/eprint/44480/ |