Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate
Parkinson's disease is caused by damage to the dopaminergic nerves in brain. Levodopa has been widely used to treat Parkinson's disease. The levodopa nano encapsulation aims to improve drug-delivery efficiency thereby increasing the concentration of released levodopa in the brain. This stu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Scientific Publishers
2023
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| Online Access: | https://umpir.ump.edu.my/id/eprint/44265/ |
| _version_ | 1848827320563924992 |
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| author | Sardjono, Ratnaningsih Eko Dhea, Salsabila Gunawan, Ramdhan Kadarohman, Asep Budiman, Anwar Vidia Afina, Nuraini Erdiwansyah, . Rizalman, Mamat Fitri, Dara Melati, Khairuddean |
| author_facet | Sardjono, Ratnaningsih Eko Dhea, Salsabila Gunawan, Ramdhan Kadarohman, Asep Budiman, Anwar Vidia Afina, Nuraini Erdiwansyah, . Rizalman, Mamat Fitri, Dara Melati, Khairuddean |
| author_sort | Sardjono, Ratnaningsih Eko |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Parkinson's disease is caused by damage to the dopaminergic nerves in brain. Levodopa has been widely used to treat Parkinson's disease. The levodopa nano encapsulation aims to improve drug-delivery efficiency thereby increasing the concentration of released levodopa in the brain. This study aims to obtain the optimum conditions for levodopa nano encapsulation in nanostarch, the characteristics of levodopa–starch nanocapsules, encapsulation efficiency, and its drug-release capabilities. Levodopa nano encapsulation has been carried out by ultrasonication method. Characterization has been carried out by FTIR, SEM, and TEM. The encapsulation efficiency is measured through changes in levodopa concentrations using a UV-Vis spectrometer. The drug release profile has been measured at pH 1.2 and 7.4 for 5 hours. The optimum conditions for levodopa nano encapsulation in nanostarch have been obtained at a mass ratio of nanostarch, maltodextrin and levodopa of 1:3:1. The SEM and TEM characterization show that levodopa–starch nanocapsules have a spherical morphology with the particle size ranged from 17.77-49.43 nm. The FTIR characterization show the presence of new peaks for C=O stretch and N-H bend. The highest encapsulation efficiency has been obtained at 46.11%. Drug release capability has been obtained by 40.93% in pH 1.2 media and 48.28% in pH 7.4 media for 5 hours of released time. |
| first_indexed | 2025-11-15T03:58:51Z |
| format | Article |
| id | ump-44265 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:58:51Z |
| publishDate | 2023 |
| publisher | Scientific Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-442652025-09-22T08:40:12Z https://umpir.ump.edu.my/id/eprint/44265/ Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate Sardjono, Ratnaningsih Eko Dhea, Salsabila Gunawan, Ramdhan Kadarohman, Asep Budiman, Anwar Vidia Afina, Nuraini Erdiwansyah, . Rizalman, Mamat Fitri, Dara Melati, Khairuddean RC Internal medicine TJ Mechanical engineering and machinery Parkinson's disease is caused by damage to the dopaminergic nerves in brain. Levodopa has been widely used to treat Parkinson's disease. The levodopa nano encapsulation aims to improve drug-delivery efficiency thereby increasing the concentration of released levodopa in the brain. This study aims to obtain the optimum conditions for levodopa nano encapsulation in nanostarch, the characteristics of levodopa–starch nanocapsules, encapsulation efficiency, and its drug-release capabilities. Levodopa nano encapsulation has been carried out by ultrasonication method. Characterization has been carried out by FTIR, SEM, and TEM. The encapsulation efficiency is measured through changes in levodopa concentrations using a UV-Vis spectrometer. The drug release profile has been measured at pH 1.2 and 7.4 for 5 hours. The optimum conditions for levodopa nano encapsulation in nanostarch have been obtained at a mass ratio of nanostarch, maltodextrin and levodopa of 1:3:1. The SEM and TEM characterization show that levodopa–starch nanocapsules have a spherical morphology with the particle size ranged from 17.77-49.43 nm. The FTIR characterization show the presence of new peaks for C=O stretch and N-H bend. The highest encapsulation efficiency has been obtained at 46.11%. Drug release capability has been obtained by 40.93% in pH 1.2 media and 48.28% in pH 7.4 media for 5 hours of released time. Scientific Publishers 2023-10 Article PeerReviewed pdf en cc_by_nc_nd_4 https://umpir.ump.edu.my/id/eprint/44265/1/Levodopa%20nanoencapsulation%20in%20nanostarch%20as%20anti-parkinsonian.pdf Sardjono, Ratnaningsih Eko and Dhea, Salsabila and Gunawan, Ramdhan and Kadarohman, Asep and Budiman, Anwar and Vidia Afina, Nuraini and Erdiwansyah, . and Rizalman, Mamat and Fitri, Dara and Melati, Khairuddean (2023) Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate. Indian Journal of Chemistry (IJC), 62 (10). pp. 1056-1060. ISSN 2583-1321. (Published) https://doi.org/10.56042/ijc.v62i10.6184 https://doi.org/10.56042/ijc.v62i10.6184 https://doi.org/10.56042/ijc.v62i10.6184 |
| spellingShingle | RC Internal medicine TJ Mechanical engineering and machinery Sardjono, Ratnaningsih Eko Dhea, Salsabila Gunawan, Ramdhan Kadarohman, Asep Budiman, Anwar Vidia Afina, Nuraini Erdiwansyah, . Rizalman, Mamat Fitri, Dara Melati, Khairuddean Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title | Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title_full | Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title_fullStr | Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title_full_unstemmed | Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title_short | Levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| title_sort | levodopa nanoencapsulation in nanostarch as anti-parkinsonian drugs candidate |
| topic | RC Internal medicine TJ Mechanical engineering and machinery |
| url | https://umpir.ump.edu.my/id/eprint/44265/ https://umpir.ump.edu.my/id/eprint/44265/ https://umpir.ump.edu.my/id/eprint/44265/ |