Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings
Titanium alloy Ti6Al4V is extensively utilized in biomedical implants owing to its advantageous mechanical characteristics and biocompatibility. Nevertheless, the presence of vanadium and aluminum ions may result in cytotoxic effects, allergic reactions, and hindered bone mineralization. To mitigate...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Russian Association of Corrosion Engineers
2024
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| Online Access: | https://umpir.ump.edu.my/id/eprint/44184/ |
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| author | Ningrum, E.O. Suroto, H. Suprapto, S. Azilah, Ajit Sumaiya, Zainal Abidin Karisma, A.D. Hamzah, A. Mamun, U.Z. Rosanti, M.S. Widiyanto, Sigit |
| author_facet | Ningrum, E.O. Suroto, H. Suprapto, S. Azilah, Ajit Sumaiya, Zainal Abidin Karisma, A.D. Hamzah, A. Mamun, U.Z. Rosanti, M.S. Widiyanto, Sigit |
| author_sort | Ningrum, E.O. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Titanium alloy Ti6Al4V is extensively utilized in biomedical implants owing to its advantageous mechanical characteristics and biocompatibility. Nevertheless, the presence of vanadium and aluminum ions may result in cytotoxic effects, allergic reactions, and hindered bone mineralization. To mitigate these concerns, a variety of surface modification techniques have been developed to improve the alloy’s biocompatibility for medical applications. Consequently, this study investigated the efficacy of a composite coating composed of hydroxyapatite, chitosan, and hyaluronic acid to enhance the biocompatibility, corrosion resistance, and antibacterial properties of Ti6Al4V implants. Different formulations of HAp/CS/HA coatings were applied to Ti6Al4V substrates through electrodeposition (40 V, 4 min), chosen for its effectiveness in achieving uniform coatings. The resulting coatings displayed a consistent morphology, and FTIR analysis validated the presence of characteristic functional groups linked to HAp, CS, and HA. The thickness of the coatings was found to be directly related to the concentration of HAp, while the incorporation of HA led to a reduction in thickness due to increased viscosity of the solution. Bioactivity evaluations in Simulated Body Fluid indicated that coatings with elevated HAp content demonstrated enhanced resistance to degradation. Importantly, the HAp/CS/HA coatings significantly improved antibacterial activity against E. coli, with formulations containing higher HAp concentrations showing the lowest corrosion rates. These results underscore the potential of HAp/CS/HA coatings in enhancing the biocompatibility, corrosion resistance, and antibacterial properties of Ti6Al4V implants, thereby improving their performance in biomedical applications. |
| first_indexed | 2025-11-15T03:58:43Z |
| format | Article |
| id | ump-44184 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:58:43Z |
| publishDate | 2024 |
| publisher | Russian Association of Corrosion Engineers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-441842025-10-17T00:41:51Z https://umpir.ump.edu.my/id/eprint/44184/ Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings Ningrum, E.O. Suroto, H. Suprapto, S. Azilah, Ajit Sumaiya, Zainal Abidin Karisma, A.D. Hamzah, A. Mamun, U.Z. Rosanti, M.S. Widiyanto, Sigit R Medicine (General) RD Surgery TP Chemical technology Titanium alloy Ti6Al4V is extensively utilized in biomedical implants owing to its advantageous mechanical characteristics and biocompatibility. Nevertheless, the presence of vanadium and aluminum ions may result in cytotoxic effects, allergic reactions, and hindered bone mineralization. To mitigate these concerns, a variety of surface modification techniques have been developed to improve the alloy’s biocompatibility for medical applications. Consequently, this study investigated the efficacy of a composite coating composed of hydroxyapatite, chitosan, and hyaluronic acid to enhance the biocompatibility, corrosion resistance, and antibacterial properties of Ti6Al4V implants. Different formulations of HAp/CS/HA coatings were applied to Ti6Al4V substrates through electrodeposition (40 V, 4 min), chosen for its effectiveness in achieving uniform coatings. The resulting coatings displayed a consistent morphology, and FTIR analysis validated the presence of characteristic functional groups linked to HAp, CS, and HA. The thickness of the coatings was found to be directly related to the concentration of HAp, while the incorporation of HA led to a reduction in thickness due to increased viscosity of the solution. Bioactivity evaluations in Simulated Body Fluid indicated that coatings with elevated HAp content demonstrated enhanced resistance to degradation. Importantly, the HAp/CS/HA coatings significantly improved antibacterial activity against E. coli, with formulations containing higher HAp concentrations showing the lowest corrosion rates. These results underscore the potential of HAp/CS/HA coatings in enhancing the biocompatibility, corrosion resistance, and antibacterial properties of Ti6Al4V implants, thereby improving their performance in biomedical applications. Russian Association of Corrosion Engineers 2024-11-13 Article PeerReviewed pdf en cc_by_nc_nd_4 https://umpir.ump.edu.my/id/eprint/44184/1/Optimizing%20titanium%20implant%20performance%20-Electrophoretic%20deposition.pdf Ningrum, E.O. and Suroto, H. and Suprapto, S. and Azilah, Ajit and Sumaiya, Zainal Abidin and Karisma, A.D. and Hamzah, A. and Mamun, U.Z. and Rosanti, M.S. and Widiyanto, Sigit (2024) Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings. International Journal of Corrosion and Scale Inhibition, 13 (4). pp. 2275-2299. ISSN 2305-6894. (Published) https://doi.org/10.17675/2305-6894-2024-13-4-20 https://doi.org/10.17675/2305-6894-2024-13-4-20 https://doi.org/10.17675/2305-6894-2024-13-4-20 |
| spellingShingle | R Medicine (General) RD Surgery TP Chemical technology Ningrum, E.O. Suroto, H. Suprapto, S. Azilah, Ajit Sumaiya, Zainal Abidin Karisma, A.D. Hamzah, A. Mamun, U.Z. Rosanti, M.S. Widiyanto, Sigit Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title | Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title_full | Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title_fullStr | Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title_full_unstemmed | Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title_short | Optimizing titanium implant performance: Electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| title_sort | optimizing titanium implant performance: electrophoretic deposition of hydroxyapatite/chitosan/hyaluronic acid coatings |
| topic | R Medicine (General) RD Surgery TP Chemical technology |
| url | https://umpir.ump.edu.my/id/eprint/44184/ https://umpir.ump.edu.my/id/eprint/44184/ https://umpir.ump.edu.my/id/eprint/44184/ |