Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review
Tissue engineering plays a vital role in the medical field that addresses the repair, regeneration, and replacement of damaged tissues or organs. The development of drug-eluting electrospun nanofiber composed of biological macromolecules plays a key role in providing localized drug delivery and stru...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier
2025
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| Online Access: | http://umpir.ump.edu.my/id/eprint/43579/ http://umpir.ump.edu.my/id/eprint/43579/1/Praveen%20IJBM%202025.pdf http://umpir.ump.edu.my/id/eprint/43579/7/Elucidating%20the%20clinker-based%20catalyst%20deactivation%20for%20biodiesel%20production%20in%20a%20continuous%20microwave-assisted%20reactor_abs.pdf |
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| author | Ramakrishnan, Praveen Ramprasath, Ramakrishnan Jalaludeen, Abdulkadhar Mohamed R., Jayakumar Gimbun, Jolius Balu, Ranganathan S.B., Mohamed T.M., Sridhar Gunasekaran, Sivagaami Sundari Davoodbasha, MubarakAli Thajuddin, Nooruddin Gnanasekaran, Lalitha Sundaram, Thanigaivel |
| author_facet | Ramakrishnan, Praveen Ramprasath, Ramakrishnan Jalaludeen, Abdulkadhar Mohamed R., Jayakumar Gimbun, Jolius Balu, Ranganathan S.B., Mohamed T.M., Sridhar Gunasekaran, Sivagaami Sundari Davoodbasha, MubarakAli Thajuddin, Nooruddin Gnanasekaran, Lalitha Sundaram, Thanigaivel |
| author_sort | Ramakrishnan, Praveen |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Tissue engineering plays a vital role in the medical field that addresses the repair, regeneration, and replacement of damaged tissues or organs. The development of drug-eluting electrospun nanofiber composed of biological macromolecules plays a key role in providing localized drug delivery and structural support. This review examines the recent development and impact of electrospun nanofibers in the field of tissue engineering and explores their potential applications. This review also investigates into the fabrication techniques of nanofibers, highlighting the use of biopolymers like collagen and chitosan, chiefly, focuses on understanding the mechanisms of drug-releasing features of these nanofibers. Studies concerning the medical applications of these nanofibers, such as wound healing, skin regeneration, bone tissue engineering, and neural repair, were also reviewed. Beyond the application in tissue regeneration, this review also explores the potential efficacy of nanofibres in cancer therapy, antibacterial activity, enzyme immobilization, and biosensing applications. This study provides an up-to-date critical insight into the applications of electrospun nanofiber application and key scalable production processes, underscoring the potential economic impacts of advanced wound care technologies. While outlining current challenges, this paper also offers future perspectives on the design, application, and potential expansion of drug-eluting electrospun fibers in medical sciences, ultimately showcasing their pivotal role in advancing therapeutic outcomes. |
| first_indexed | 2025-11-15T03:52:18Z |
| format | Article |
| id | ump-43579 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:52:18Z |
| publishDate | 2025 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-435792025-01-15T04:56:18Z http://umpir.ump.edu.my/id/eprint/43579/ Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review Ramakrishnan, Praveen Ramprasath, Ramakrishnan Jalaludeen, Abdulkadhar Mohamed R., Jayakumar Gimbun, Jolius Balu, Ranganathan S.B., Mohamed T.M., Sridhar Gunasekaran, Sivagaami Sundari Davoodbasha, MubarakAli Thajuddin, Nooruddin Gnanasekaran, Lalitha Sundaram, Thanigaivel QD Chemistry RS Pharmacy and materia medica T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Tissue engineering plays a vital role in the medical field that addresses the repair, regeneration, and replacement of damaged tissues or organs. The development of drug-eluting electrospun nanofiber composed of biological macromolecules plays a key role in providing localized drug delivery and structural support. This review examines the recent development and impact of electrospun nanofibers in the field of tissue engineering and explores their potential applications. This review also investigates into the fabrication techniques of nanofibers, highlighting the use of biopolymers like collagen and chitosan, chiefly, focuses on understanding the mechanisms of drug-releasing features of these nanofibers. Studies concerning the medical applications of these nanofibers, such as wound healing, skin regeneration, bone tissue engineering, and neural repair, were also reviewed. Beyond the application in tissue regeneration, this review also explores the potential efficacy of nanofibres in cancer therapy, antibacterial activity, enzyme immobilization, and biosensing applications. This study provides an up-to-date critical insight into the applications of electrospun nanofiber application and key scalable production processes, underscoring the potential economic impacts of advanced wound care technologies. While outlining current challenges, this paper also offers future perspectives on the design, application, and potential expansion of drug-eluting electrospun fibers in medical sciences, ultimately showcasing their pivotal role in advancing therapeutic outcomes. Elsevier 2025 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/43579/1/Praveen%20IJBM%202025.pdf pdf en http://umpir.ump.edu.my/id/eprint/43579/7/Elucidating%20the%20clinker-based%20catalyst%20deactivation%20for%20biodiesel%20production%20in%20a%20continuous%20microwave-assisted%20reactor_abs.pdf Ramakrishnan, Praveen and Ramprasath, Ramakrishnan and Jalaludeen, Abdulkadhar Mohamed and R., Jayakumar and Gimbun, Jolius and Balu, Ranganathan and S.B., Mohamed and T.M., Sridhar and Gunasekaran, Sivagaami Sundari and Davoodbasha, MubarakAli and Thajuddin, Nooruddin and Gnanasekaran, Lalitha and Sundaram, Thanigaivel (2025) Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review. International Journal of Biological Macromolecules, 296 (139663). pp. 1-22. ISSN 0141-8130. (Published) https://doi.org/10.1016/j.ijbiomac.2025.139663 https://doi.org/10.1016/j.ijbiomac.2025.139663 |
| spellingShingle | QD Chemistry RS Pharmacy and materia medica T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Ramakrishnan, Praveen Ramprasath, Ramakrishnan Jalaludeen, Abdulkadhar Mohamed R., Jayakumar Gimbun, Jolius Balu, Ranganathan S.B., Mohamed T.M., Sridhar Gunasekaran, Sivagaami Sundari Davoodbasha, MubarakAli Thajuddin, Nooruddin Gnanasekaran, Lalitha Sundaram, Thanigaivel Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title | Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title_full | Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title_fullStr | Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title_full_unstemmed | Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title_short | Electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: A review |
| title_sort | electrospun nanofibers of collagen and chitosan for tissue engineering and drug delivery applications: a review |
| topic | QD Chemistry RS Pharmacy and materia medica T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/43579/ http://umpir.ump.edu.my/id/eprint/43579/ http://umpir.ump.edu.my/id/eprint/43579/ http://umpir.ump.edu.my/id/eprint/43579/1/Praveen%20IJBM%202025.pdf http://umpir.ump.edu.my/id/eprint/43579/7/Elucidating%20the%20clinker-based%20catalyst%20deactivation%20for%20biodiesel%20production%20in%20a%20continuous%20microwave-assisted%20reactor_abs.pdf |