Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products
Cosmetics typically contain artificial substances that could be harmful to people's health. Extended usage and exposure to these harmful substances are frequently linked to a number of negative impacts and illnesses. This study processed a Durio zibethinus rind, rich in natural antityrosinase p...
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| Format: | Article |
| Language: | English English |
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Elsevier
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/42793/ http://umpir.ump.edu.my/id/eprint/42793/1/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind_ABST.pdf http://umpir.ump.edu.my/id/eprint/42793/2/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind.pdf |
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| author | Sofiyyah, Ismail Erna Normaya, . Syamimi Sulfiza, Shamsuri Anwar, Iqbal Mohd Bijarimi, Mat Piah Sharifuddin, Md Zain Mohammad Norazmi, Ahmad |
| author_facet | Sofiyyah, Ismail Erna Normaya, . Syamimi Sulfiza, Shamsuri Anwar, Iqbal Mohd Bijarimi, Mat Piah Sharifuddin, Md Zain Mohammad Norazmi, Ahmad |
| author_sort | Sofiyyah, Ismail |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Cosmetics typically contain artificial substances that could be harmful to people's health. Extended usage and exposure to these harmful substances are frequently linked to a number of negative impacts and illnesses. This study processed a Durio zibethinus rind, rich in natural antityrosinase properties, with a chemometric-assisted green extraction system. The TPC value was obtained at the optimum conditions (34.4 MPa, 62°C, and 86 min). GC-MS and FTIR spectroscopy were performed to identify the phenolic compounds and their functional group, respectively. The optimized extract contains 77 % of the mushroom tyrosinase activity. PCA shows that aspidospermidin-17-ol,1-acetyl-19,21-apoxy-15,16-dimethoxy- (AP) resembles the similar cluster with hydroquinone. COSMO-RS was used to investigate the extraction mechanism of CO2 and AP during the SFE process. DFT and molecular docking were used to calculate the chemical reactivity and explain the tyrosinase inhibition mechanism, respectively. ADME-Tox and OSIRIS Property Explorer showed no violation of Lipinski’s rule, and toxicity with AP. In conclusion, a high-value, natural and safe cosmetic ingredient (AP) for cosmetopea was discovered using an innovative green extraction system. |
| first_indexed | 2025-11-15T03:49:02Z |
| format | Article |
| id | ump-42793 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:49:02Z |
| publishDate | 2024 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-427932024-10-14T07:47:45Z http://umpir.ump.edu.my/id/eprint/42793/ Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products Sofiyyah, Ismail Erna Normaya, . Syamimi Sulfiza, Shamsuri Anwar, Iqbal Mohd Bijarimi, Mat Piah Sharifuddin, Md Zain Mohammad Norazmi, Ahmad TP Chemical technology Cosmetics typically contain artificial substances that could be harmful to people's health. Extended usage and exposure to these harmful substances are frequently linked to a number of negative impacts and illnesses. This study processed a Durio zibethinus rind, rich in natural antityrosinase properties, with a chemometric-assisted green extraction system. The TPC value was obtained at the optimum conditions (34.4 MPa, 62°C, and 86 min). GC-MS and FTIR spectroscopy were performed to identify the phenolic compounds and their functional group, respectively. The optimized extract contains 77 % of the mushroom tyrosinase activity. PCA shows that aspidospermidin-17-ol,1-acetyl-19,21-apoxy-15,16-dimethoxy- (AP) resembles the similar cluster with hydroquinone. COSMO-RS was used to investigate the extraction mechanism of CO2 and AP during the SFE process. DFT and molecular docking were used to calculate the chemical reactivity and explain the tyrosinase inhibition mechanism, respectively. ADME-Tox and OSIRIS Property Explorer showed no violation of Lipinski’s rule, and toxicity with AP. In conclusion, a high-value, natural and safe cosmetic ingredient (AP) for cosmetopea was discovered using an innovative green extraction system. Elsevier 2024-08-26 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42793/1/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind_ABST.pdf pdf en http://umpir.ump.edu.my/id/eprint/42793/2/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind.pdf Sofiyyah, Ismail and Erna Normaya, . and Syamimi Sulfiza, Shamsuri and Anwar, Iqbal and Mohd Bijarimi, Mat Piah and Sharifuddin, Md Zain and Mohammad Norazmi, Ahmad (2024) Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products. The Journal of Supercritical Fluids, 214 (106393). pp. 1-14. ISSN 0896-8446. (Published) https://doi.org/10.1016/j.supflu.2024.106393 https://doi.org/10.1016/j.supflu.2024.106393 |
| spellingShingle | TP Chemical technology Sofiyyah, Ismail Erna Normaya, . Syamimi Sulfiza, Shamsuri Anwar, Iqbal Mohd Bijarimi, Mat Piah Sharifuddin, Md Zain Mohammad Norazmi, Ahmad Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title | Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title_full | Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title_fullStr | Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title_full_unstemmed | Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title_short | Chemometric assisted green extraction of tyrosinase inhibitor from Durio zibethinus rind for skin whitening agents in cosmetic products |
| title_sort | chemometric assisted green extraction of tyrosinase inhibitor from durio zibethinus rind for skin whitening agents in cosmetic products |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/42793/ http://umpir.ump.edu.my/id/eprint/42793/ http://umpir.ump.edu.my/id/eprint/42793/ http://umpir.ump.edu.my/id/eprint/42793/1/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind_ABST.pdf http://umpir.ump.edu.my/id/eprint/42793/2/Chemometric%20assisted%20green%20extraction%20of%20tyrosinase%20inhibitor%20from%20Durio%20zibethinus%20rind.pdf |