Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design
Gastroretentive Floating Drug Delivery Systems (GRFDDS) are long-acting oral dosage forms that float on gastric juice and remain in the stomach for an elongated period gradually delivering drug substances to the upper part of the gastrointestinal system. This study aims to develop and enhance the bi...
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| Format: | Article |
| Language: | English |
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University of Malaya
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/42735/ http://umpir.ump.edu.my/id/eprint/42735/1/Optimization%20of%20non-effervescent%20riboflavin%20gastroretentive%20floating%20tablets%20using%20mixture%20design.pdf |
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| author | Arobi Katha, Umme Tabassum Muhammad Sofwan, Sapiyan Fatini Nasuha, Ahmad Puad Nik Sofea Aliya, Nik Aris Mohd Akmal, Azhar |
| author_facet | Arobi Katha, Umme Tabassum Muhammad Sofwan, Sapiyan Fatini Nasuha, Ahmad Puad Nik Sofea Aliya, Nik Aris Mohd Akmal, Azhar |
| author_sort | Arobi Katha, Umme Tabassum |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Gastroretentive Floating Drug Delivery Systems (GRFDDS) are long-acting oral dosage forms that float on gastric juice and remain in the stomach for an elongated period gradually delivering drug substances to the upper part of the gastrointestinal system. This study aims to develop and enhance the bioavailability and stomach retention of non-effervescent riboflavin floating tablets by using a variety of polymers. In this investigation, both pre-compression evaluation and post-compression of all the tablet materials were performed according to USP specifications. In vitro, buoyancy analyses were carried out to achieve minimum floating lag time and maximum floating duration. The tablet employed direct compression methods using HPMC K17, Carbopol 940p, and polypropylene foam powder. In vitro, buoyancy studies were performed to achieve minimum floating lag time and maximum floating duration. Tablets were evaluated for physicochemical properties according to USP specifications. An optimized tablet with a floating lag time of 0.77 minutes and a floating time of 48.74 minutes was developed using Design of Experiments (DoE). The results indicated that the optimized formulation, designated as Y, performed the best. It consists of 0.45% polypropylene foam powder, 0.15% HPMC K17, and 0% Carbopol 940p. The developed non-effervescent riboflavin floating tablets have the potential to improve the bioavailability and therapeutic efficacy of riboflavin by enhancing its gastric residence time |
| first_indexed | 2025-11-15T03:48:48Z |
| format | Article |
| id | ump-42735 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:48:48Z |
| publishDate | 2024 |
| publisher | University of Malaya |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-427352024-10-03T06:27:20Z http://umpir.ump.edu.my/id/eprint/42735/ Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design Arobi Katha, Umme Tabassum Muhammad Sofwan, Sapiyan Fatini Nasuha, Ahmad Puad Nik Sofea Aliya, Nik Aris Mohd Akmal, Azhar TP Chemical technology Gastroretentive Floating Drug Delivery Systems (GRFDDS) are long-acting oral dosage forms that float on gastric juice and remain in the stomach for an elongated period gradually delivering drug substances to the upper part of the gastrointestinal system. This study aims to develop and enhance the bioavailability and stomach retention of non-effervescent riboflavin floating tablets by using a variety of polymers. In this investigation, both pre-compression evaluation and post-compression of all the tablet materials were performed according to USP specifications. In vitro, buoyancy analyses were carried out to achieve minimum floating lag time and maximum floating duration. The tablet employed direct compression methods using HPMC K17, Carbopol 940p, and polypropylene foam powder. In vitro, buoyancy studies were performed to achieve minimum floating lag time and maximum floating duration. Tablets were evaluated for physicochemical properties according to USP specifications. An optimized tablet with a floating lag time of 0.77 minutes and a floating time of 48.74 minutes was developed using Design of Experiments (DoE). The results indicated that the optimized formulation, designated as Y, performed the best. It consists of 0.45% polypropylene foam powder, 0.15% HPMC K17, and 0% Carbopol 940p. The developed non-effervescent riboflavin floating tablets have the potential to improve the bioavailability and therapeutic efficacy of riboflavin by enhancing its gastric residence time University of Malaya 2024 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42735/1/Optimization%20of%20non-effervescent%20riboflavin%20gastroretentive%20floating%20tablets%20using%20mixture%20design.pdf Arobi Katha, Umme Tabassum and Muhammad Sofwan, Sapiyan and Fatini Nasuha, Ahmad Puad and Nik Sofea Aliya, Nik Aris and Mohd Akmal, Azhar (2024) Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design. Asia-Pacific Journal of Molecular Biology and Biotechnology, 32 (3). pp. 257-266. ISSN 0128-7451. (Published) https://doi.org/10.35118/apjmbb.2024.032.3.23 10.35118/apjmbb.2024.032.3.23 |
| spellingShingle | TP Chemical technology Arobi Katha, Umme Tabassum Muhammad Sofwan, Sapiyan Fatini Nasuha, Ahmad Puad Nik Sofea Aliya, Nik Aris Mohd Akmal, Azhar Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title | Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title_full | Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title_fullStr | Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title_full_unstemmed | Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title_short | Optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| title_sort | optimization of non-effervescent riboflavin gastroretentive floating tablets using mixture design |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/42735/ http://umpir.ump.edu.my/id/eprint/42735/ http://umpir.ump.edu.my/id/eprint/42735/ http://umpir.ump.edu.my/id/eprint/42735/1/Optimization%20of%20non-effervescent%20riboflavin%20gastroretentive%20floating%20tablets%20using%20mixture%20design.pdf |