Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa
The antioxidant capacity by DPPH radical scavenging and antimicrobial activity by disk diffusion and broth microdilution method of nine isolated alkaloids from T. crispa were evaluated. All isolated alkaloids had been divided into three groups which were aporphine alkaloids, N-formylannonaine (1), N...
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Trans Tech Publications
2021
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| Online Access: | http://umpir.ump.edu.my/id/eprint/42679/ http://umpir.ump.edu.my/id/eprint/42679/1/MSF.1025.163%20alkaloid.pdf http://umpir.ump.edu.my/id/eprint/42679/7/Antioxidant%20and%20Antimicrobial%20Screening_ABST.pdf |
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| author | Hazrulrizawati, Abd Hamid Roziasyahira, Mutazah Izzah Hayati, Yahya Zeyohannes, Senait Sileshi |
| author_facet | Hazrulrizawati, Abd Hamid Roziasyahira, Mutazah Izzah Hayati, Yahya Zeyohannes, Senait Sileshi |
| author_sort | Hazrulrizawati, Abd Hamid |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The antioxidant capacity by DPPH radical scavenging and antimicrobial activity by disk diffusion and broth microdilution method of nine isolated alkaloids from T. crispa were evaluated. All isolated alkaloids had been divided into three groups which were aporphine alkaloids, N-formylannonaine (1), N-formylnornuciferine (2), magnoflorine (9), oxoaporphine alkaloids, lysicamine (3) and liriodenine (4); and protoberberine alkaloids, columbamine(6), dihydrodiscretamine (7) and 4,13-dihydroxy-2,8,9-trimethoxydibenzo [a,g]quinolizinium (8). Protoberberine alkaloids showed (IC50 > 500-800 μg/mL) radical scavenging activity while oxaporphine alkaloids inhibited the growth of the Gram-positive bacteria, Staphylococcus aureus (+) and Enterococcus faecalis (+).The antioxidant and antimicrobial properties of different compounds support documented traditional use of T. crispa in wound healing and treatment of rheumatic, diarrhoea, ulcers, itches and wounds. Results of the present biological activity investigation further points to the potential of this plant species as a good source of natural antioxidant and preservative in food industry. |
| first_indexed | 2025-11-15T03:48:36Z |
| format | Conference or Workshop Item |
| id | ump-42679 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:48:36Z |
| publishDate | 2021 |
| publisher | Trans Tech Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-426792024-10-01T06:22:42Z http://umpir.ump.edu.my/id/eprint/42679/ Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa Hazrulrizawati, Abd Hamid Roziasyahira, Mutazah Izzah Hayati, Yahya Zeyohannes, Senait Sileshi Q Science (General) QD Chemistry The antioxidant capacity by DPPH radical scavenging and antimicrobial activity by disk diffusion and broth microdilution method of nine isolated alkaloids from T. crispa were evaluated. All isolated alkaloids had been divided into three groups which were aporphine alkaloids, N-formylannonaine (1), N-formylnornuciferine (2), magnoflorine (9), oxoaporphine alkaloids, lysicamine (3) and liriodenine (4); and protoberberine alkaloids, columbamine(6), dihydrodiscretamine (7) and 4,13-dihydroxy-2,8,9-trimethoxydibenzo [a,g]quinolizinium (8). Protoberberine alkaloids showed (IC50 > 500-800 μg/mL) radical scavenging activity while oxaporphine alkaloids inhibited the growth of the Gram-positive bacteria, Staphylococcus aureus (+) and Enterococcus faecalis (+).The antioxidant and antimicrobial properties of different compounds support documented traditional use of T. crispa in wound healing and treatment of rheumatic, diarrhoea, ulcers, itches and wounds. Results of the present biological activity investigation further points to the potential of this plant species as a good source of natural antioxidant and preservative in food industry. Trans Tech Publications 2021 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/42679/1/MSF.1025.163%20alkaloid.pdf pdf en http://umpir.ump.edu.my/id/eprint/42679/7/Antioxidant%20and%20Antimicrobial%20Screening_ABST.pdf Hazrulrizawati, Abd Hamid and Roziasyahira, Mutazah and Izzah Hayati, Yahya and Zeyohannes, Senait Sileshi (2021) Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa. In: Materials Science Forum. 2nd Postgraduate Symposium on Industrial Science and Technology, SISTEC 2020 , 26 - 27 August 2020 , Virtual, Online. pp. 163-168., 1025. ISSN 0255-5476 ISBN 978-303573757-8 (Published) https://doi.org/10.4028/www.scientific.net/MSF.1025.163 https://doi.org/10.4028/www.scientific.net/MSF.1025.163 |
| spellingShingle | Q Science (General) QD Chemistry Hazrulrizawati, Abd Hamid Roziasyahira, Mutazah Izzah Hayati, Yahya Zeyohannes, Senait Sileshi Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title | Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title_full | Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title_fullStr | Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title_full_unstemmed | Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title_short | Antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| title_sort | antioxidant and antimicrobial screening of isolated alkaloids from tinospora crispa |
| topic | Q Science (General) QD Chemistry |
| url | http://umpir.ump.edu.my/id/eprint/42679/ http://umpir.ump.edu.my/id/eprint/42679/ http://umpir.ump.edu.my/id/eprint/42679/ http://umpir.ump.edu.my/id/eprint/42679/1/MSF.1025.163%20alkaloid.pdf http://umpir.ump.edu.my/id/eprint/42679/7/Antioxidant%20and%20Antimicrobial%20Screening_ABST.pdf |