Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method
Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commerc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Elsevier B.V.
2023
|
| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/41800/ http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf |
| _version_ | 1848826435731456000 |
|---|---|
| author | AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz |
| author_facet | AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz |
| author_sort | AL-japairai, Khater Ahmed Saeed |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value. As a solution, amorphous solid dispersion (ASD) was introduced as a drug formulation method that improves drug solubility by changing the molecular structure of the drugs from crystalline to amorphous. The hot melt extrusion (HME) method is emerging in the pharmaceutical industry as an alternative to manufacture ASD. However, despite solving solubility issues, ASD also exposes the drug to a high risk of crystallisation, either during processing or storage. Formulating a successful oral administration drug using ASD requires optimisation of the formulation, polymers, and HME manufacturing processes applied. This review presents some important considerations in ASD formulation, including strategies to improve the stability of the final product using HME to allow more new drugs to be formulated using this method. |
| first_indexed | 2025-11-15T03:44:47Z |
| format | Article |
| id | ump-41800 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:44:47Z |
| publishDate | 2023 |
| publisher | Elsevier B.V. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-418002024-08-30T00:05:51Z http://umpir.ump.edu.my/id/eprint/41800/ Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Oral administration of drugs is preferred over other routes for several reasons: it is non-invasive, easy to administer, and easy to store. However, drug formulation for oral administration is often hindered by the drug's poor solubility, which limits its bioavailability and reduces its commercial value. As a solution, amorphous solid dispersion (ASD) was introduced as a drug formulation method that improves drug solubility by changing the molecular structure of the drugs from crystalline to amorphous. The hot melt extrusion (HME) method is emerging in the pharmaceutical industry as an alternative to manufacture ASD. However, despite solving solubility issues, ASD also exposes the drug to a high risk of crystallisation, either during processing or storage. Formulating a successful oral administration drug using ASD requires optimisation of the formulation, polymers, and HME manufacturing processes applied. This review presents some important considerations in ASD formulation, including strategies to improve the stability of the final product using HME to allow more new drugs to be formulated using this method. Elsevier B.V. 2023-11-25 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf pdf en http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf AL-japairai, Khater Ahmed Saeed and Almurisi, Samah Hamed and Syed, Mahmood and Madheswaran, Thiagarajan and Chatterjee, Bappaditya and Sri, Prasanthi and Nadiatul Azra, Ahmad Mazlan and Al Hagbani, Turki and Alheibshy, Fawaz (2023) Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method. International Journal of Pharmaceutics, 647 (123536). pp. 1-13. ISSN 0378-5173. (Published) https://doi.org/10.1016/j.ijpharm.2023.123536 https://doi.org/10.1016/j.ijpharm.2023.123536 |
| spellingShingle | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology AL-japairai, Khater Ahmed Saeed Almurisi, Samah Hamed Syed, Mahmood Madheswaran, Thiagarajan Chatterjee, Bappaditya Sri, Prasanthi Nadiatul Azra, Ahmad Mazlan Al Hagbani, Turki Alheibshy, Fawaz Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title | Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title_full | Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title_fullStr | Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title_full_unstemmed | Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title_short | Strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (HME) method |
| title_sort | strategies to improve the stability of amorphous solid dispersions in view of the hot melt extrusion (hme) method |
| topic | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/41800/ http://umpir.ump.edu.my/id/eprint/41800/ http://umpir.ump.edu.my/id/eprint/41800/ http://umpir.ump.edu.my/id/eprint/41800/1/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions.pdf http://umpir.ump.edu.my/id/eprint/41800/2/Strategies%20to%20improve%20the%20stability%20of%20amorphous%20solid%20dispersions%20in%20view%20of%20the%20hot%20melt%20extrusion%20%28HME%29%20method_ABS.pdf |