Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis
The anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically a...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Language: | English English |
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Wiley
2024
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| Online Access: | http://umpir.ump.edu.my/id/eprint/41733/ http://umpir.ump.edu.my/id/eprint/41733/1/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites.pdf http://umpir.ump.edu.my/id/eprint/41733/2/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites%20and%20their%20therapeutic%20potential%20for%20rheumatoid%20arthritis.pdf |
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| author | Yuandani, . Ibrahim, Jantan Emil, Salim Septama, Abdi Wira Kamal, Rullah Nainu, Firzan Mohd Fadhlizil Fasihi, Mohd Aluwi Emran, Talhah Roney, Miah Nur Aini Khairunnisa, . Nasution, Halimah Raina As'ad, Muh. Fadhil Nur Farisya, Shamsudin Maryam Aisyah, Abdullah Rani Marwa, Haya Luthfiyyah Al Chaira, Diany Mahabbah Nabila Aulia, . |
| author_facet | Yuandani, . Ibrahim, Jantan Emil, Salim Septama, Abdi Wira Kamal, Rullah Nainu, Firzan Mohd Fadhlizil Fasihi, Mohd Aluwi Emran, Talhah Roney, Miah Nur Aini Khairunnisa, . Nasution, Halimah Raina As'ad, Muh. Fadhil Nur Farisya, Shamsudin Maryam Aisyah, Abdullah Rani Marwa, Haya Luthfiyyah Al Chaira, Diany Mahabbah Nabila Aulia, . |
| author_sort | Yuandani, . |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti-inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti-inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes. These phytochemicals have potential as safer alternatives to the existing drugs in the management of RA, which possess a wide range of serious side effects. Sufficient preclinical studies on safety and efficacy of these phytochemicals must be performed prior to proper clinical studies. Further studies are needed to address the barriers that have so far limited their human use before the therapeutic potential of these plant-based chemicals as anti-arthritic agents in the treatment of RA is fully realized. |
| first_indexed | 2025-11-15T03:44:28Z |
| format | Article |
| id | ump-41733 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:44:28Z |
| publishDate | 2024 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-417332024-06-28T05:18:40Z http://umpir.ump.edu.my/id/eprint/41733/ Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis Yuandani, . Ibrahim, Jantan Emil, Salim Septama, Abdi Wira Kamal, Rullah Nainu, Firzan Mohd Fadhlizil Fasihi, Mohd Aluwi Emran, Talhah Roney, Miah Nur Aini Khairunnisa, . Nasution, Halimah Raina As'ad, Muh. Fadhil Nur Farisya, Shamsudin Maryam Aisyah, Abdullah Rani Marwa, Haya Luthfiyyah Al Chaira, Diany Mahabbah Nabila Aulia, . HD Industries. Land use. Labor R Medicine (General) TP Chemical technology The anti-inflammatory and immunosuppressive activities of plant secondary metabolites are due to their diverse mechanisms of action against multifarious molecular targets such as modulation of the complex immune system associated with rheumatoid arthritis (RA). This review discussed and critically analyzed the potent anti-inflammatory and immunosuppressive effects of several phytochemicals and their underlying mechanisms in association with RA in experimental studies, including preliminary clinical studies of some of them. A wide range of phytochemicals including phenols, flavonoids, chalcones, xanthones, terpenoids, alkaloids, and glycosides have shown significant immunosuppressive and anti-inflammatory activities in experimental RA models and a few have undergone clinical trials for their efficacy and safety in reducing RA symptoms and improve patient outcomes. These phytochemicals have potential as safer alternatives to the existing drugs in the management of RA, which possess a wide range of serious side effects. Sufficient preclinical studies on safety and efficacy of these phytochemicals must be performed prior to proper clinical studies. Further studies are needed to address the barriers that have so far limited their human use before the therapeutic potential of these plant-based chemicals as anti-arthritic agents in the treatment of RA is fully realized. Wiley 2024 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/41733/1/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites.pdf pdf en http://umpir.ump.edu.my/id/eprint/41733/2/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites%20and%20their%20therapeutic%20potential%20for%20rheumatoid%20arthritis.pdf Yuandani, . and Ibrahim, Jantan and Emil, Salim and Septama, Abdi Wira and Kamal, Rullah and Nainu, Firzan and Mohd Fadhlizil Fasihi, Mohd Aluwi and Emran, Talhah and Roney, Miah and Nur Aini Khairunnisa, . and Nasution, Halimah Raina and As'ad, Muh. Fadhil and Nur Farisya, Shamsudin and Maryam Aisyah, Abdullah and Rani Marwa, Haya Luthfiyyah and Al Chaira, Diany Mahabbah and Nabila Aulia, . (2024) Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis. Phytotherapy Research, 38 (6). pp. 2931-2961. ISSN 0951-418X. (Published) https://doi.org/10.1002/ptr.8147 10.1002/ptr.8147 |
| spellingShingle | HD Industries. Land use. Labor R Medicine (General) TP Chemical technology Yuandani, . Ibrahim, Jantan Emil, Salim Septama, Abdi Wira Kamal, Rullah Nainu, Firzan Mohd Fadhlizil Fasihi, Mohd Aluwi Emran, Talhah Roney, Miah Nur Aini Khairunnisa, . Nasution, Halimah Raina As'ad, Muh. Fadhil Nur Farisya, Shamsudin Maryam Aisyah, Abdullah Rani Marwa, Haya Luthfiyyah Al Chaira, Diany Mahabbah Nabila Aulia, . Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title | Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title_full | Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title_fullStr | Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title_full_unstemmed | Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title_short | Mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| title_sort | mechanistic insights into anti-inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis |
| topic | HD Industries. Land use. Labor R Medicine (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/41733/ http://umpir.ump.edu.my/id/eprint/41733/ http://umpir.ump.edu.my/id/eprint/41733/ http://umpir.ump.edu.my/id/eprint/41733/1/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites.pdf http://umpir.ump.edu.my/id/eprint/41733/2/Mechanistic%20insights%20into%20anti-inflammatory%20and%20immunosuppressive%20effects%20of%20plant%20secondary%20metabolites%20and%20their%20therapeutic%20potential%20for%20rheumatoid%20arthritis.pdf |