Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system
Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target...
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| Format: | Article |
| Language: | English English |
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Institute of Electrical and Electronics Engineers Inc.
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/40842/ http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf |
| _version_ | 1848826162643468288 |
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| author | Yamashita, Kei Kishimoto, Kouhei Kuroda, Hiroto Wang, Jin Sakai, Kenji Mohd Mawardi, Saari Kiwa, Toshihiko |
| author_facet | Yamashita, Kei Kishimoto, Kouhei Kuroda, Hiroto Wang, Jin Sakai, Kenji Mohd Mawardi, Saari Kiwa, Toshihiko |
| author_sort | Yamashita, Kei |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target biomarker. In this study, we aim to improve the accuracy of the MIA, we evaluated the AC magnetic properties of MNPs in the biological solvents. To measure the magnetic signal of MNPs, we used the developed HTS-SQUID magnetic immunoassay system. First, we evaluated the instability of the HTS-SQUID magnetic immunoassay system using pellets of manganese (II) fluoride. The results show that the device instability due to operating time does not affect the measurement of magnetic signal changes in MNPs due to biological solvents. Since the magnetic properties of MNPs depend on particle size and viscosity, we measured the time evolution of the magnetic signal of Resovist in glycerin, human serum, sheep whole blood, and NaCl. It was found that the magnetic signal of Resovist decreased exponentially with ions contained in the solvent. The results are fitted as the exponential double function, suggesting that the magnetic signal of MNPs in biological solvents is affected by the aggregation of MNPs in the blood and that there are at least two steps in the mechanism of the aggregation. |
| first_indexed | 2025-11-15T03:40:26Z |
| format | Article |
| id | ump-40842 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:40:26Z |
| publishDate | 2023 |
| publisher | Institute of Electrical and Electronics Engineers Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-408422024-05-28T08:04:01Z http://umpir.ump.edu.my/id/eprint/40842/ Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system Yamashita, Kei Kishimoto, Kouhei Kuroda, Hiroto Wang, Jin Sakai, Kenji Mohd Mawardi, Saari Kiwa, Toshihiko T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Magnetic nanoparticles (MNPs) have been studied for various medical applications by taking advantage of their unique magnetic properties. Magnetic immunoassay (MIA) is a technique for the rapid detection of target biomarkers by antigen-antibody reaction between antibody-modified MNPs and the target biomarker. In this study, we aim to improve the accuracy of the MIA, we evaluated the AC magnetic properties of MNPs in the biological solvents. To measure the magnetic signal of MNPs, we used the developed HTS-SQUID magnetic immunoassay system. First, we evaluated the instability of the HTS-SQUID magnetic immunoassay system using pellets of manganese (II) fluoride. The results show that the device instability due to operating time does not affect the measurement of magnetic signal changes in MNPs due to biological solvents. Since the magnetic properties of MNPs depend on particle size and viscosity, we measured the time evolution of the magnetic signal of Resovist in glycerin, human serum, sheep whole blood, and NaCl. It was found that the magnetic signal of Resovist decreased exponentially with ions contained in the solvent. The results are fitted as the exponential double function, suggesting that the magnetic signal of MNPs in biological solvents is affected by the aggregation of MNPs in the blood and that there are at least two steps in the mechanism of the aggregation. Institute of Electrical and Electronics Engineers Inc. 2023-08-01 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf pdf en http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf Yamashita, Kei and Kishimoto, Kouhei and Kuroda, Hiroto and Wang, Jin and Sakai, Kenji and Mohd Mawardi, Saari and Kiwa, Toshihiko (2023) Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system. IEEE Transactions on Applied Superconductivity, 33 (1600405). pp. 1-5. ISSN 1051-8223. (Published) https://doi.org/10.1109/TASC.2023.3239830 https://doi.org/10.1109/TASC.2023.3239830 |
| spellingShingle | T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering Yamashita, Kei Kishimoto, Kouhei Kuroda, Hiroto Wang, Jin Sakai, Kenji Mohd Mawardi, Saari Kiwa, Toshihiko Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title | Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title_full | Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title_fullStr | Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title_full_unstemmed | Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title_short | Aggregation of magnetic nanoparticles in biological solvents evaluated by HTS-SQUID magnetic immunoassay system |
| title_sort | aggregation of magnetic nanoparticles in biological solvents evaluated by hts-squid magnetic immunoassay system |
| topic | T Technology (General) TA Engineering (General). Civil engineering (General) TK Electrical engineering. Electronics Nuclear engineering |
| url | http://umpir.ump.edu.my/id/eprint/40842/ http://umpir.ump.edu.my/id/eprint/40842/ http://umpir.ump.edu.my/id/eprint/40842/ http://umpir.ump.edu.my/id/eprint/40842/1/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents.pdf http://umpir.ump.edu.my/id/eprint/40842/2/Aggregation%20of%20magnetic%20nanoparticles%20in%20biological%20solvents%20evaluated%20by%20HTS-SQUID%20magnetic%20immunoassay%20system_ABS.pdf |