Prediction of blood-brain barrier permeability of compounds by machine learning algorithms

QR Code

Prediction of blood-brain barrier permeability of compounds by machine learning algorithms

In the drug development for the Central Nervous System (CNS), the discovery of the compounds that can pass through the brain across the Blood-Brain Barrier (BBB) is the most challenging assessment. Almost 98% of small molecules are unable to permeate BBB, reducing the pharmacokinetics of the drugs i...

Full description

Bibliographic Details
Main Authors:	Feng, Tan wei, Raihana Zahirah, Edros, Ngahzaifa, Ab Ghani, Siti Umairah, Mokhtar, Dong, Ruihai
Format:	Article
Language:	English
Published:	Semarak Ilmu Publishing 2024
Subjects:	HD28 Management. Industrial Management QA75 Electronic computers. Computer science T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology
Online Access:	http://umpir.ump.edu.my/id/eprint/39985/ http://umpir.ump.edu.my/id/eprint/39985/1/Prediction%20of%20blood-brain%20barrier%20permeability%20of%20compounds%20by%20machine.pdf

Similar Items

Utilizing machine learning techniques to predict the blood-brain barrier permeability of compounds detected using LCQTOF-MS in Malaysian Kelulut honey
by: Raihana Zahirah, Edros, et al.
Published: (2023)

Identification of novel competitive antagonists for Histamine H1 receptor in Malaysian kelulut honey
by: Feng, Tan wei, et al.
Published: (2025)

Blood-Brain Barrier on-a-chip model for the study of drug permeability into the brain
by: Whitehouse, Chloe Ann
Published: (2022)

Synthesis Of Blood-Brain Barrier Permeable Aurones As Modulators Of Microglia
by: Chia, Shi Yi
Published: (2023)

The roles of acidity, peroxide and non-peroxide compounds in antibacterial properties of Malaysian Kelulut, Tualang and Acacia honey
by: Mohd Amir Shahlan, Mohd-Aspar, et al.
Published: (2023)

Changes Of The Blood-Brain Barrier Permeability, Ultrastructure, And Protein And Gene Expressions In A Rat Model Of Cerebral Hypoperfusion
by: Sekaran, Hema
Published: (2019)

Safety of anodal transcranial direct current stimulation with respect to blood-brain barrier permeability in the rat
by: Nik-Mohd-Afizan, NAR, et al.
Published: (2017)

Phytocannabinoids, neuroprotection and the blood-brain barrier
by: Stone, Nicole
Published: (2021)

Blood-brain barrier derangement after electrical brain stimulation
by: Watanabe, Yumiko, et al.
Published: (2017)

A comparative study on autism among children using machine learning classiﬁcation
by: Ainie Hayati, Noruzman, et al.
Published: (2022)

A comparative study on autism among children using machine learning classification
by: Ainie Hayati, Noruzman, et al.
Published: (2022)

Establishment of horse blood-brain barrier model for the study of drug delivery to the brain
by: Gupta, Gaurav
Published: (2025)

In-vitro drug release studies of chitosan-alginate nanoparticles loaded with non-volatile extracts of cymbopogon species
by: Rahman, Md Shamim, et al.
Published: (2024)

Machine learning classification to detect unattended child in vehicle using sensor signal : A review
by: Ida Fadliza, Abu Zarin, et al.
Published: (2023)

Regional cerebral blood perfusion changes in chronic stroke survivors as potential brain correlates of the functional outcome following gamiied home-based rehabilitation (IntelliRehab)—a pilot study
by: Firwana, Younis M.S., et al.

Construction of in vitro Blood-Brain Barrier (BBB) model using MDCK-1 cell line
by: Mohd Nor, Nor Hafizah, et al.
Published: (2014)

Alterations in the endothelial cells of the blood-brain barrier in cerebral malaria
by: Mohd Nasir, Mohd Hamzah, et al.
Published: (2012)

Endocannabinoids modulate human blood-brain barrier permeabilityin vitro
by: Hind, William H., et al.
Published: (2015)

Drug Permeation across the Blood-Brain Barrier: Applications of Nanotechnology
by: Fakhoury, M., et al.
Published: (2015)

Modern methods for delivery of drugs across the blood-brain barrier
by: Chen, Yan, et al.
Published: (2012)

Nipah virus neurotropism: insights into blood-brain barrier disruption
by: Al Obaidi, Mazen M Jamil, et al.
Published: (2024)

An Unexpected Transient Breakdown of the Blood Brain Barrier Triggers Passage of Large Intravenously Administered Nanoparticles
by: Smith, N.M., et al.
Published: (2016)

Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood–brain barrier hyperpermeability
by: Allen, C.L., et al.
Published: (2009)

The barriers and challenges of ISO 14001 environmental management system implementation in Malaysia industry
by: Lee, Li Fei
Published: (2016)

Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases
by: Mansor, Nur Izzati, et al.
Published: (2019)

The effect of diesel exhaust emission on blood brain barrier integrity and function
by: Heidari Nejad, Sayeh
Published: (2014)

Understanding the mechanisms underlying the disruption of the blood–brain barrier in parasitic infections
by: Jamil Al‐Obaidi, Mazen M., et al.
Published: (2024)

An enhanced feature selection and cancer classiﬁcation for microarray data using relaxed Lasso and support vector machine
by: Aina Umairah, Mazlan, et al.
Published: (2021)

A review on disaster prediction using machine learning
by: Farghaly, Alaa Taiseer, et al.
Published: (2024)

Unsupervised Abnormalities Extraction and Brain Segmentation
by: Tong Hau, Lee, et al.
Published: (2008)

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids
by: Brook, E., et al.
Published: (2019)

Polymeric micelles anchored with TAT for delivery of antibiotics across the blood-brain barrier
by: Liu, Lihong, et al.
Published: (2008)

Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat
by: Takechi, Ryusuke, et al.
Published: (2012)

Fabrication of nanoemulsion loaded with cefuroxime for efficient translocation across the blood brain barrier
by: Harun, Siti Norhawani
Published: (2018)

In Vitro blood-brain barrier models for neuroinfectious diseases: a narrative review
by: Badawi, Ahmad Hussein, et al.
Published: (2024)

Barriers factor of ISO 9001:2015 implementation in the manufacturing industry of Pakistan
by: Khan, Zohaib
Published: (2021)

Pre-Processing of Low-Field Brain MRI
by: N. F., Ishak, et al.
Published: (2008)

Empower halal cosmetics sector
by: Raihana Z., Edros, et al.
Published: (2022)

Whitening of Background Brain Activity via Parametric Modeling
by: Kamel, Nidal, et al.
Published: (2007)

Stepwise regression of agarwood oil significant chemical compounds into four quality differentiation
by: Siti Mariatul Hazwa, Mohd Huzir, et al.
Published: (2023)