Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications
A paper presents the design, fabrication, and thermal evaluation of a printed circuit board (PCB) based copper (Cu) microheater that can be integrated with microfluidic chips to initiate the loop-mediated isothermal amplification (LAMP). A series of 3D finite element electro-thermal simulations were...
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| Format: | Article |
| Language: | English English |
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Elsevier
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/39298/ http://umpir.ump.edu.my/id/eprint/39298/1/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications%20%28intro%29.pdf http://umpir.ump.edu.my/id/eprint/39298/2/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications.pdf |
| _version_ | 1848825732252303360 |
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| author | Ezhilnavaroji, Jeroish Zachariah Bhuvaneshwari, K. S. Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran |
| author_facet | Ezhilnavaroji, Jeroish Zachariah Bhuvaneshwari, K. S. Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran |
| author_sort | Ezhilnavaroji, Jeroish Zachariah |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | A paper presents the design, fabrication, and thermal evaluation of a printed circuit board (PCB) based copper (Cu) microheater that can be integrated with microfluidic chips to initiate the loop-mediated isothermal amplification (LAMP). A series of 3D finite element electro-thermal simulations were carried out to analyze the thermal uniformity and power consumption of the micro heater. The optimal design was fabricated using the etching technique and analyzed with a heat spreader to enhance thermal uniformity. The simulation results of the microheater reveal that the meander configuration outperforms other designs. In addition, the microheater with a heat spreader has a thermal difference of only < 5 ℃ when compared with ∼10 ℃ in a microheater without a heat spreader. The developed microheater has a long shelf life and can be used to handle wet biological samples when encapsulated with polyethylene terephthalate (PET). The paper microfluidic chip on the glass substrate has a temperature difference of only 0.5 ℃. The low-cost microheater integrated microfluidic chips has the great potential to develop inexpensive home-based diagnostic kits and trigger the access of diagnostic kits in underdeveloped countries to reduce the spread of infection and initiate treatment plans. |
| first_indexed | 2025-11-15T03:33:36Z |
| format | Article |
| id | ump-39298 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:33:36Z |
| publishDate | 2023 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-392982023-11-14T06:12:25Z http://umpir.ump.edu.my/id/eprint/39298/ Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications Ezhilnavaroji, Jeroish Zachariah Bhuvaneshwari, K. S. Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran T Technology (General) TK Electrical engineering. Electronics Nuclear engineering A paper presents the design, fabrication, and thermal evaluation of a printed circuit board (PCB) based copper (Cu) microheater that can be integrated with microfluidic chips to initiate the loop-mediated isothermal amplification (LAMP). A series of 3D finite element electro-thermal simulations were carried out to analyze the thermal uniformity and power consumption of the micro heater. The optimal design was fabricated using the etching technique and analyzed with a heat spreader to enhance thermal uniformity. The simulation results of the microheater reveal that the meander configuration outperforms other designs. In addition, the microheater with a heat spreader has a thermal difference of only < 5 ℃ when compared with ∼10 ℃ in a microheater without a heat spreader. The developed microheater has a long shelf life and can be used to handle wet biological samples when encapsulated with polyethylene terephthalate (PET). The paper microfluidic chip on the glass substrate has a temperature difference of only 0.5 ℃. The low-cost microheater integrated microfluidic chips has the great potential to develop inexpensive home-based diagnostic kits and trigger the access of diagnostic kits in underdeveloped countries to reduce the spread of infection and initiate treatment plans. Elsevier 2023 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39298/1/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications%20%28intro%29.pdf pdf en http://umpir.ump.edu.my/id/eprint/39298/2/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications.pdf Ezhilnavaroji, Jeroish Zachariah and Bhuvaneshwari, K. S. and Futane, Abhishek and Fahmi, Samsuri and Narayanamurthy, Vigneswaran (2023) Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications. Materials Today Communications, 36 (106663). ISSN 2352-4928. (Published) https://doi.org/10.1016/j.mtcomm.2023.106663 10.1016/j.mtcomm.2023.106663 |
| spellingShingle | T Technology (General) TK Electrical engineering. Electronics Nuclear engineering Ezhilnavaroji, Jeroish Zachariah Bhuvaneshwari, K. S. Futane, Abhishek Fahmi, Samsuri Narayanamurthy, Vigneswaran Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title | Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title_full | Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title_fullStr | Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title_full_unstemmed | Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title_short | Design, optimization, fabrication and analysis of Cu microheater for loop-mediated isothermal amplification (LAMP) applications |
| title_sort | design, optimization, fabrication and analysis of cu microheater for loop-mediated isothermal amplification (lamp) applications |
| topic | T Technology (General) TK Electrical engineering. Electronics Nuclear engineering |
| url | http://umpir.ump.edu.my/id/eprint/39298/ http://umpir.ump.edu.my/id/eprint/39298/ http://umpir.ump.edu.my/id/eprint/39298/ http://umpir.ump.edu.my/id/eprint/39298/1/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications%20%28intro%29.pdf http://umpir.ump.edu.my/id/eprint/39298/2/Design%2C%20optimization%2C%20fabrication%20and%20analysis%20of%20Cu%20microheater%20for%20loop-mediated%20isothermal%20amplification%20%28LAMP%29%20applications.pdf |