A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation
A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The...
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| Format: | Article |
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Springer
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/39285/ http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf |
| _version_ | 1848825729099235328 |
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| author | AL-japairai, Khater Ahmed Saeed Syed, Mahmood Nadiya, Abdul Halim Almurisi, Samah Hamed |
| author_facet | AL-japairai, Khater Ahmed Saeed Syed, Mahmood Nadiya, Abdul Halim Almurisi, Samah Hamed |
| author_sort | AL-japairai, Khater Ahmed Saeed |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The method showed high sensitivity with good reproducibility of results. The limit of detection and the limit of quantification were 0.34 and 1.02 μg/mL, respectively. The calibration curve was constructed by plotting a graph of the absorbance versus concentration. The coefficient of correlation was higher than 0.99. The regression equation of this curve is y = 0.0544x – 0.0526. The percentage of drug recovery was found in the acceptable range (99.72 – 101.66%), and the coefficient of variation for the precision of this method was found to be less than 2.0. The proposed method can be suitable for the analysis of benidipine in tablet formulations for quality control purposes. |
| first_indexed | 2025-11-15T03:33:33Z |
| format | Article |
| id | ump-39285 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:33:33Z |
| publishDate | 2023 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-392852023-11-14T02:48:25Z http://umpir.ump.edu.my/id/eprint/39285/ A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation AL-japairai, Khater Ahmed Saeed Syed, Mahmood Nadiya, Abdul Halim Almurisi, Samah Hamed TP Chemical technology A simple, sensitive and specific ultraviolet spectrophotometric method has been established for the determination of benidipine hydrochloride. The wavelength of maximum absorbance (λmax) for benidipine was found to be 237 nm. Linearity of this method was observed in a range of 2.0 – 16.0 μg/mL. The method showed high sensitivity with good reproducibility of results. The limit of detection and the limit of quantification were 0.34 and 1.02 μg/mL, respectively. The calibration curve was constructed by plotting a graph of the absorbance versus concentration. The coefficient of correlation was higher than 0.99. The regression equation of this curve is y = 0.0544x – 0.0526. The percentage of drug recovery was found in the acceptable range (99.72 – 101.66%), and the coefficient of variation for the precision of this method was found to be less than 2.0. The proposed method can be suitable for the analysis of benidipine in tablet formulations for quality control purposes. Springer 2023-02 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf pdf en http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf AL-japairai, Khater Ahmed Saeed and Syed, Mahmood and Nadiya, Abdul Halim and Almurisi, Samah Hamed (2023) A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation. Pharmaceutical Chemistry Journal, 56 (11). 1506 -1511. ISSN 0091-150X. (Published) https://doi.org/10.1007/s11094-023-02822-3 https://doi.org/10.1007/s11094-023-02822-3 |
| spellingShingle | TP Chemical technology AL-japairai, Khater Ahmed Saeed Syed, Mahmood Nadiya, Abdul Halim Almurisi, Samah Hamed A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title | A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title_full | A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title_fullStr | A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title_full_unstemmed | A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title_short | A new and rapid UV-Visible spectrophotometric method for benidipine hydrochloride determination: Development and validation |
| title_sort | new and rapid uv-visible spectrophotometric method for benidipine hydrochloride determination: development and validation |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/39285/ http://umpir.ump.edu.my/id/eprint/39285/ http://umpir.ump.edu.my/id/eprint/39285/ http://umpir.ump.edu.my/id/eprint/39285/2/A%20New%20and%20Rapid%20UV-Visible%20Spectrophotometric%20Method.pdf http://umpir.ump.edu.my/id/eprint/39285/3/A%20new%20and%20rapid%20UV-Visible%20spectrophotometric%20method_abst.pdf |