Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling
Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failu...
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| Format: | Conference or Workshop Item |
| Language: | English English |
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Institute of Electrical and Electronics Engineers Inc.
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/39079/ http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf |
| _version_ | 1848825677644562432 |
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| author | Siti Munirah, Muhammad Ali El-Bouri, Wahbi K. Mohd Jamil, Mohamed Mokhtarudin |
| author_facet | Siti Munirah, Muhammad Ali El-Bouri, Wahbi K. Mohd Jamil, Mohamed Mokhtarudin |
| author_sort | Siti Munirah, Muhammad Ali |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failure occurrence. Model parameters including the systemic and pulmonary arterial compliance and resistance, and the left ventricular elastance are calculated for different ages using a ratio-based method. These parameters are then used in the lumped-parameter model. Our findings show that as age increases, there is a leftward and a rightward shift in the left ventricle and right ventricle pressure-volume loops, respectively. For the left ventricle, there is a decrease in stroke volume and an increase in ventricular pressure as the age increases. This correlates with the occurrence of arterial hypertension in the older population. Meanwhile, the right ventricular pressure is maintained as the population gets older, despite the increase in the stroke volume. This is possibly due to the shift in intraventricular septum that causes an enlargement of the right ventricle as the age increases. This study provides understanding on the effect of age on the occurrence of heart failure.This study demonstrates the relationship of aging with cardiac hemodynamics, which provides the potential risk of heart failure occurrence. Although there are many risk factors that can cause heart failure, aging has been strongly associated with its occurrence. Understanding how age affects heart failure can help to differentiate them from other effects such as dietary, gender, and early cardiovascular diseases including arrhythmia and myocardial infarction. |
| first_indexed | 2025-11-15T03:32:44Z |
| format | Conference or Workshop Item |
| id | ump-39079 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:32:44Z |
| publishDate | 2022 |
| publisher | Institute of Electrical and Electronics Engineers Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-390792023-11-14T03:39:21Z http://umpir.ump.edu.my/id/eprint/39079/ Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling Siti Munirah, Muhammad Ali El-Bouri, Wahbi K. Mohd Jamil, Mohamed Mokhtarudin T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering TS Manufactures Age is a major risk for heart failure, which is associated with the reduction in ventricular compliance, increase in arterial stiffening, and increase in systemic vascular resistance. In this study, a lumped-parameter model is used to investigate the effect of aging on the possibility of heart failure occurrence. Model parameters including the systemic and pulmonary arterial compliance and resistance, and the left ventricular elastance are calculated for different ages using a ratio-based method. These parameters are then used in the lumped-parameter model. Our findings show that as age increases, there is a leftward and a rightward shift in the left ventricle and right ventricle pressure-volume loops, respectively. For the left ventricle, there is a decrease in stroke volume and an increase in ventricular pressure as the age increases. This correlates with the occurrence of arterial hypertension in the older population. Meanwhile, the right ventricular pressure is maintained as the population gets older, despite the increase in the stroke volume. This is possibly due to the shift in intraventricular septum that causes an enlargement of the right ventricle as the age increases. This study provides understanding on the effect of age on the occurrence of heart failure.This study demonstrates the relationship of aging with cardiac hemodynamics, which provides the potential risk of heart failure occurrence. Although there are many risk factors that can cause heart failure, aging has been strongly associated with its occurrence. Understanding how age affects heart failure can help to differentiate them from other effects such as dietary, gender, and early cardiovascular diseases including arrhythmia and myocardial infarction. Institute of Electrical and Electronics Engineers Inc. 2022 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf pdf en http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf Siti Munirah, Muhammad Ali and El-Bouri, Wahbi K. and Mohd Jamil, Mohamed Mokhtarudin (2022) Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling. In: 7th IEEE-EMBS Conference on Biomedical Engineering and Sciences, IECBES 2022 - Proceedings , 7-9 December 2022 , Virtual, Online. pp. 160-164. (187642). ISBN 978-166549469-4 (Published) https://doi.org/10.1109/IECBES54088.2022.10079315 |
| spellingShingle | T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering TS Manufactures Siti Munirah, Muhammad Ali El-Bouri, Wahbi K. Mohd Jamil, Mohamed Mokhtarudin Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title | Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title_full | Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title_fullStr | Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title_full_unstemmed | Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title_short | Age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| title_sort | age-based sensitivity analysis on cardiac hemodynamics using lumped-parameter modelling |
| topic | T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TK Electrical engineering. Electronics Nuclear engineering TS Manufactures |
| url | http://umpir.ump.edu.my/id/eprint/39079/ http://umpir.ump.edu.my/id/eprint/39079/ http://umpir.ump.edu.my/id/eprint/39079/1/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped.pdf http://umpir.ump.edu.my/id/eprint/39079/2/Age-based%20sensitivity%20analysis%20on%20cardiac%20hemodynamics%20using%20lumped-parameter%20modelling_ABS.pdf |