3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities
Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/38862/ http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf |
| _version_ | 1848825618154651648 |
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| author | Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin A. Elfadil, Abdelgadir |
| author_facet | Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin A. Elfadil, Abdelgadir |
| author_sort | Aldhaher, Abdullah |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. |
| first_indexed | 2025-11-15T03:31:47Z |
| format | Article |
| id | ump-38862 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:31:47Z |
| publishDate | 2023 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-388622023-10-12T06:16:28Z http://umpir.ump.edu.my/id/eprint/38862/ 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin A. Elfadil, Abdelgadir QD Chemistry TP Chemical technology Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials. Elsevier Ltd 2023 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf Aldhaher, Abdullah and Shahabipour, Fahimeh and Shaito, Abdullah and Al-Assaf, Saphwan and Elnour, Ahmed A.M. and Sallam, El Bashier and Teimourtash, Shahin and A. Elfadil, Abdelgadir (2023) 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities. Heliyon, 9 (7). ISSN 2405-8440. (Published) https://doi.org/10.1016/j.heliyon.2023.e17050 10.1016/j.heliyon.2023.e17050 |
| spellingShingle | QD Chemistry TP Chemical technology Aldhaher, Abdullah Shahabipour, Fahimeh Shaito, Abdullah Al-Assaf, Saphwan Elnour, Ahmed A.M. Sallam, El Bashier Teimourtash, Shahin A. Elfadil, Abdelgadir 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title_full | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title_fullStr | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title_full_unstemmed | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title_short | 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities |
| title_sort | 3d hydrogel/ bioactive glass scaffolds in bone tissue engineering: status and future opportunities |
| topic | QD Chemistry TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/38862/ http://umpir.ump.edu.my/id/eprint/38862/ http://umpir.ump.edu.my/id/eprint/38862/ http://umpir.ump.edu.my/id/eprint/38862/1/Dr.%20Ahmed_%20Helyion_Research%20Artical.pdf |