Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms
Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and t...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2023
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/38330/ http://umpir.ump.edu.my/id/eprint/38330/1/Baicalein%20as%20promising%20anticancer%20agent_A%20comprehensive%20analysis%20on%20molecular%20mechanisms.pdf |
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| author | Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md. Sanower Hasan, Md. Mehedi Hasibuzzaman, Md. Al Rahaman, Tanjim Ishraq Mia, Md. Abdur Rashid Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md. Nazmul Ming, Long Chiau Tan, Ching Siang |
| author_facet | Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md. Sanower Hasan, Md. Mehedi Hasibuzzaman, Md. Al Rahaman, Tanjim Ishraq Mia, Md. Abdur Rashid Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md. Nazmul Ming, Long Chiau Tan, Ching Siang |
| author_sort | Morshed, A K M Helal |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein’s anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study. |
| first_indexed | 2025-11-15T03:29:37Z |
| format | Article |
| id | ump-38330 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:29:37Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-383302023-11-06T03:29:30Z http://umpir.ump.edu.my/id/eprint/38330/ Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md. Sanower Hasan, Md. Mehedi Hasibuzzaman, Md. Al Rahaman, Tanjim Ishraq Mia, Md. Abdur Rashid Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md. Nazmul Ming, Long Chiau Tan, Ching Siang RC Internal medicine TP Chemical technology Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) and radio- and chemo-resistance limit their effectiveness and result in unfavorable health consequences. Natural compounds are generally considered safer than synthetic drugs, and their use in cancer treatment alone, or in combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein in combination with conventional medicines have been reported, and some of them have also undergone clinical trials in later stages. As a result, we investigated the prospects of Baicalein, a naturally occurring substance extracted from the stems of Scutellaria baicalensis Georgi and Oroxylum indicum Kurz, which targets a wide range of molecular changes that are involved in cancer development. In other words, this review is primarily driven by the findings from studies of Baicalein therapy in several cancer cell populations based on promising pre-clinical research. The modifications of numerous signal transduction mechanisms and transcriptional agents have been highlighted as the major players for Baicalein’s anti-malignant properties at the micro level. These include AKT serine/threonine protein kinase B (AKT) as well as PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 & 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated protein kinase (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer and activator of transcription 3 (STAT3), Nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated protein kinase (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, and Sonic hedgehog (Shh) signaling cascades. The promise of Baicalein as an anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element for treating various malignancies and its capability to inhibit malignant stem cells, evidence of synergistic effects, and design of nanomedicine-based drugs are altogether well supported by the data presented in this review study. MDPI 2023-04 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/38330/1/Baicalein%20as%20promising%20anticancer%20agent_A%20comprehensive%20analysis%20on%20molecular%20mechanisms.pdf Morshed, A K M Helal and Paul, Supti and Hossain, Arafat and Basak, Tuli and Hossain, Md. Sanower and Hasan, Md. Mehedi and Hasibuzzaman, Md. Al and Rahaman, Tanjim Ishraq and Mia, Md. Abdur Rashid and Shing, Pollob and Sohel, Md and Bibi, Shabana and Dey, Dipta and Biswas, Partha and Hasan, Md. Nazmul and Ming, Long Chiau and Tan, Ching Siang (2023) Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms. Cancers, 15 (2128). pp. 1-28. ISSN 2072-6694. (Published) https://doi.org/10.3390/cancers15072128 https://doi.org/10.3390/cancers15072128 |
| spellingShingle | RC Internal medicine TP Chemical technology Morshed, A K M Helal Paul, Supti Hossain, Arafat Basak, Tuli Hossain, Md. Sanower Hasan, Md. Mehedi Hasibuzzaman, Md. Al Rahaman, Tanjim Ishraq Mia, Md. Abdur Rashid Shing, Pollob Sohel, Md Bibi, Shabana Dey, Dipta Biswas, Partha Hasan, Md. Nazmul Ming, Long Chiau Tan, Ching Siang Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title | Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title_full | Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title_fullStr | Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title_full_unstemmed | Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title_short | Baicalein as promising anticancer agent_A comprehensive analysis on molecular mechanisms |
| title_sort | baicalein as promising anticancer agent_a comprehensive analysis on molecular mechanisms |
| topic | RC Internal medicine TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/38330/ http://umpir.ump.edu.my/id/eprint/38330/ http://umpir.ump.edu.my/id/eprint/38330/ http://umpir.ump.edu.my/id/eprint/38330/1/Baicalein%20as%20promising%20anticancer%20agent_A%20comprehensive%20analysis%20on%20molecular%20mechanisms.pdf |