Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery
The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and extracellular vesicles (EVs), require extensive reformulation to suit the requirements of PDD. LPs are artificial vesicles co...
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| Format: | Article |
| Language: | English |
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MDPI
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/38210/ http://umpir.ump.edu.my/id/eprint/38210/1/Liposomes%20or%20extracellular%20vesicles_A%20comprehensive%20comparison%20of%20both%20lipid%20bilayer%20vesicles.pdf |
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| author | Al-Jipouri, Ali Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Latifah Munirah, Bakar Doolaanea, Abd Almonem |
| author_facet | Al-Jipouri, Ali Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Latifah Munirah, Bakar Doolaanea, Abd Almonem |
| author_sort | Al-Jipouri, Ali |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and extracellular vesicles (EVs), require extensive reformulation to suit the requirements of PDD. LPs are artificial vesicles composed of lipid bilayers capable of encapsulating hydrophilic and hydrophobic substances, whereas EVs are natural vesicles secreted by cells. Additionally, novel LPs-EVs hybrid vesicles may confer the best of both. The preparation methods of EVs are distinguished from LPs since they rely mainly on extraction and purification, whereas the LPs are synthesized from their basic ingredients. Similarly, drug loading methods into/onto EVs are distinguished whereby they are cell- or non-cell-based, whereas LPs are loaded via passive or active approaches. This review discusses the progress in LPs and EVs as well as hybrid vesicles with a special focus on PDD. It also provides a perspective comparison between LPs and EVs from various aspects (composition, preparation/extraction, drug loading, and large-scale manufacturing) as well as the future prospects for inhaled therapeutics. In addition, it discusses the challenges that may be encountered in scaling up the production and presents our view regarding the clinical translation of the laboratory findings into commercial products. |
| first_indexed | 2025-11-15T03:29:07Z |
| format | Article |
| id | ump-38210 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:29:07Z |
| publishDate | 2023 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-382102023-09-05T03:35:37Z http://umpir.ump.edu.my/id/eprint/38210/ Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery Al-Jipouri, Ali Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Latifah Munirah, Bakar Doolaanea, Abd Almonem QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology The rapid and non-invasive pulmonary drug delivery (PDD) has attracted great attention compared to the other routes. However, nanoparticle platforms, like liposomes (LPs) and extracellular vesicles (EVs), require extensive reformulation to suit the requirements of PDD. LPs are artificial vesicles composed of lipid bilayers capable of encapsulating hydrophilic and hydrophobic substances, whereas EVs are natural vesicles secreted by cells. Additionally, novel LPs-EVs hybrid vesicles may confer the best of both. The preparation methods of EVs are distinguished from LPs since they rely mainly on extraction and purification, whereas the LPs are synthesized from their basic ingredients. Similarly, drug loading methods into/onto EVs are distinguished whereby they are cell- or non-cell-based, whereas LPs are loaded via passive or active approaches. This review discusses the progress in LPs and EVs as well as hybrid vesicles with a special focus on PDD. It also provides a perspective comparison between LPs and EVs from various aspects (composition, preparation/extraction, drug loading, and large-scale manufacturing) as well as the future prospects for inhaled therapeutics. In addition, it discusses the challenges that may be encountered in scaling up the production and presents our view regarding the clinical translation of the laboratory findings into commercial products. MDPI 2023-01 Article PeerReviewed pdf en cc_by_4 http://umpir.ump.edu.my/id/eprint/38210/1/Liposomes%20or%20extracellular%20vesicles_A%20comprehensive%20comparison%20of%20both%20lipid%20bilayer%20vesicles.pdf Al-Jipouri, Ali and Almurisi, Samah Hamed and AL-japairai, Khater Ahmed Saeed and Latifah Munirah, Bakar and Doolaanea, Abd Almonem (2023) Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery. Polymers, 15 (318). pp. 1-63. ISSN 2073-4360. (Published) https://doi.org/10.3390/polym15020318 https://doi.org/10.3390/polym15020318 |
| spellingShingle | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology Al-Jipouri, Ali Almurisi, Samah Hamed AL-japairai, Khater Ahmed Saeed Latifah Munirah, Bakar Doolaanea, Abd Almonem Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title | Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title_full | Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title_fullStr | Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title_full_unstemmed | Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title_short | Liposomes or extracellular vesicles : A comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| title_sort | liposomes or extracellular vesicles : a comprehensive comparison of both lipid bilayer vesicles for pulmonary drug delivery |
| topic | QD Chemistry T Technology (General) TA Engineering (General). Civil engineering (General) TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/38210/ http://umpir.ump.edu.my/id/eprint/38210/ http://umpir.ump.edu.my/id/eprint/38210/ http://umpir.ump.edu.my/id/eprint/38210/1/Liposomes%20or%20extracellular%20vesicles_A%20comprehensive%20comparison%20of%20both%20lipid%20bilayer%20vesicles.pdf |