Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study
Cadmium (Cd) is a heavy metal with various human exposure sources. It accumulates in the liver, forming a complex with metallothionein protein and progresses to other organs. As a heavy metal, cadmium can replace calcium and other divalent ions and disturb their cascades, ultimately affecting the vi...
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| Format: | Article |
| Language: | English English |
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John Wiley and Sons
2023
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| Online Access: | http://umpir.ump.edu.my/id/eprint/37867/ http://umpir.ump.edu.my/id/eprint/37867/1/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs.pdf http://umpir.ump.edu.my/id/eprint/37867/2/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs_FULL.pdf |
| _version_ | 1848825366848733184 |
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| author | Syed, Murtaza H. Rubab, Syeda A. Abbas, Syed R. Qutaba, Syed Mior Ahmad Khushairi, Mohd Zahari |
| author_facet | Syed, Murtaza H. Rubab, Syeda A. Abbas, Syed R. Qutaba, Syed Mior Ahmad Khushairi, Mohd Zahari |
| author_sort | Syed, Murtaza H. |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | Cadmium (Cd) is a heavy metal with various human exposure sources. It accumulates in the liver, forming a complex with metallothionein protein and progresses to other organs. As a heavy metal, cadmium can replace calcium and other divalent ions and disturb their cascades, ultimately affecting the vital organs. Since cadmium acetate (CA) is considered more lethal than other Cd compounds, the current study examines the effect of different concentrations of CA doses in drinking water for different exposure times in murine models (Mus musculus). After the exposure period, the murine models were then examined histopathologically and biochemically. The histopathological examination of the heart, liver, and kidneys of the experimental group showed extensive degenerative effects. Atomic absorption spectroscopy was used to determine the quantity of cadmium in serum, kidney, and hepatic tissues. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of hepatic proteins, especially metallothionein, directly related to Cd administration. The biochemical parameters, including creatine kinase, alanine aminotransferase, aspartate aminotransferase, total proteins, glucose, urea, uric acid, and creatinine, were also analyzed. After thorough histochemical and biochemical analysis, it was concluded that even low dose exposure of CA is hazardous to murine models with damaging effects. |
| first_indexed | 2025-11-15T03:27:47Z |
| format | Article |
| id | ump-37867 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T03:27:47Z |
| publishDate | 2023 |
| publisher | John Wiley and Sons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-378672023-06-26T07:26:39Z http://umpir.ump.edu.my/id/eprint/37867/ Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study Syed, Murtaza H. Rubab, Syeda A. Abbas, Syed R. Qutaba, Syed Mior Ahmad Khushairi, Mohd Zahari QD Chemistry TP Chemical technology Cadmium (Cd) is a heavy metal with various human exposure sources. It accumulates in the liver, forming a complex with metallothionein protein and progresses to other organs. As a heavy metal, cadmium can replace calcium and other divalent ions and disturb their cascades, ultimately affecting the vital organs. Since cadmium acetate (CA) is considered more lethal than other Cd compounds, the current study examines the effect of different concentrations of CA doses in drinking water for different exposure times in murine models (Mus musculus). After the exposure period, the murine models were then examined histopathologically and biochemically. The histopathological examination of the heart, liver, and kidneys of the experimental group showed extensive degenerative effects. Atomic absorption spectroscopy was used to determine the quantity of cadmium in serum, kidney, and hepatic tissues. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of hepatic proteins, especially metallothionein, directly related to Cd administration. The biochemical parameters, including creatine kinase, alanine aminotransferase, aspartate aminotransferase, total proteins, glucose, urea, uric acid, and creatinine, were also analyzed. After thorough histochemical and biochemical analysis, it was concluded that even low dose exposure of CA is hazardous to murine models with damaging effects. John Wiley and Sons 2023-05 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/37867/1/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs.pdf pdf en http://umpir.ump.edu.my/id/eprint/37867/2/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs_FULL.pdf Syed, Murtaza H. and Rubab, Syeda A. and Abbas, Syed R. and Qutaba, Syed and Mior Ahmad Khushairi, Mohd Zahari (2023) Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study. Journal of Biochemical and Molecular Toxicology, ahead of print (ahead of print). pp. 1-20. ISSN 1095-6670. (In Press / Online First) (In Press / Online First) https://doi.org/10.1002/jbt.23382 https://doi.org/10.1002/jbt.23382 |
| spellingShingle | QD Chemistry TP Chemical technology Syed, Murtaza H. Rubab, Syeda A. Abbas, Syed R. Qutaba, Syed Mior Ahmad Khushairi, Mohd Zahari Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title | Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title_full | Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title_fullStr | Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title_full_unstemmed | Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title_short | Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study |
| title_sort | effects of cadmium acetate contaminated drinking water on vital organs: a histopathological and biochemical study |
| topic | QD Chemistry TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/37867/ http://umpir.ump.edu.my/id/eprint/37867/ http://umpir.ump.edu.my/id/eprint/37867/ http://umpir.ump.edu.my/id/eprint/37867/1/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs.pdf http://umpir.ump.edu.my/id/eprint/37867/2/Effects%20of%20cadmium%20acetate%20contaminated%20drinking%20water%20on%20vital%20organs_FULL.pdf |