Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application
The hard capsule market growth is mainly driven by the demand for gelatin capsules made of animals. Plant-based hard capsules, such as hydroxypropyl methylcellulose are currently in high demand for drug delivery, but the manufacturing process is costly with limited reagent supply. As an alternative,...
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| Language: | English |
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Trans Tech Publications Ltd
2022
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| Online Access: | http://umpir.ump.edu.my/id/eprint/37118/ http://umpir.ump.edu.my/id/eprint/37118/1/Ramli%202022_Solid%20State%20Phenomena%20%281%29.pdf |
| _version_ | 1848825170494488576 |
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| author | Nur Amalina, Ramli Nurul Natasya Amira, Kamaluddin Fatmawati, Adam |
| author_facet | Nur Amalina, Ramli Nurul Natasya Amira, Kamaluddin Fatmawati, Adam |
| author_sort | Nur Amalina, Ramli |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The hard capsule market growth is mainly driven by the demand for gelatin capsules made of animals. Plant-based hard capsules, such as hydroxypropyl methylcellulose are currently in high demand for drug delivery, but the manufacturing process is costly with limited reagent supply. As an alternative, carrageenan from seaweed was used as a film-forming agent in this work. Carrageenan film possesses low mechanical strength, thus gum Arabic is incorporated to strengthen the biocomposite film. The films and hard capsules were produced with different concentrations of gum Arabic, ranging from 0 to 2.0 w/v%. The tensile strength and elongation at break were enhanced to 56.8 MPa and 23.7%, respectively. The highest capsule loop strength is 32.5 N, which was achieved at 1.2 w/v% of gum Arabic. All biocomposite films were kept at a moisture content of 13%, which is comparable to gelatin hard capsules. These results demonstrate that gum Arabic can strengthen the carrageenan biocomposite to be an alternative to gelatin hard capsules. |
| first_indexed | 2025-11-15T03:24:40Z |
| format | Article |
| id | ump-37118 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T03:24:40Z |
| publishDate | 2022 |
| publisher | Trans Tech Publications Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-371182023-11-14T06:48:51Z http://umpir.ump.edu.my/id/eprint/37118/ Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application Nur Amalina, Ramli Nurul Natasya Amira, Kamaluddin Fatmawati, Adam TP Chemical technology The hard capsule market growth is mainly driven by the demand for gelatin capsules made of animals. Plant-based hard capsules, such as hydroxypropyl methylcellulose are currently in high demand for drug delivery, but the manufacturing process is costly with limited reagent supply. As an alternative, carrageenan from seaweed was used as a film-forming agent in this work. Carrageenan film possesses low mechanical strength, thus gum Arabic is incorporated to strengthen the biocomposite film. The films and hard capsules were produced with different concentrations of gum Arabic, ranging from 0 to 2.0 w/v%. The tensile strength and elongation at break were enhanced to 56.8 MPa and 23.7%, respectively. The highest capsule loop strength is 32.5 N, which was achieved at 1.2 w/v% of gum Arabic. All biocomposite films were kept at a moisture content of 13%, which is comparable to gelatin hard capsules. These results demonstrate that gum Arabic can strengthen the carrageenan biocomposite to be an alternative to gelatin hard capsules. Trans Tech Publications Ltd 2022-12 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/37118/1/Ramli%202022_Solid%20State%20Phenomena%20%281%29.pdf Nur Amalina, Ramli and Nurul Natasya Amira, Kamaluddin and Fatmawati, Adam (2022) Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application. Solid State Phenomena, 340. pp. 11-18. ISSN 1662-9779. (Published) https://doi.org/10.4028/p-c2wejl https://doi.org/10.4028/p-c2wejl |
| spellingShingle | TP Chemical technology Nur Amalina, Ramli Nurul Natasya Amira, Kamaluddin Fatmawati, Adam Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title | Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title_full | Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title_fullStr | Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title_full_unstemmed | Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title_short | Mechanical, Structural and Physical Properties of Carrageenan-Gum Arabic Biocomposite Film for Hard Capsule Application |
| title_sort | mechanical, structural and physical properties of carrageenan-gum arabic biocomposite film for hard capsule application |
| topic | TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/37118/ http://umpir.ump.edu.my/id/eprint/37118/ http://umpir.ump.edu.my/id/eprint/37118/ http://umpir.ump.edu.my/id/eprint/37118/1/Ramli%202022_Solid%20State%20Phenomena%20%281%29.pdf |