Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation
The current study offers controlled release of niacinamide from fibrous silica (KCC-1) loaded in a face serum formulation. Furthermore, three drug loading methods, namely physical mixing, melting, and solvent evaporation, denoted as (Phy)/Nia-KCC-1, (Mel)/Nia-KCC-1, and (Sol)/Nia-KCC-1, respectively...
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| Format: | Conference or Workshop Item |
| Language: | English English English |
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Elsevier Ltd
2023
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/36797/ http://umpir.ump.edu.my/id/eprint/36797/1/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier%20in%20face%20serum%20formulation.pdf http://umpir.ump.edu.my/id/eprint/36797/7/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier.pdf http://umpir.ump.edu.my/id/eprint/36797/8/Controlled%20release%20of%20niacinamide_ABST.pdf |
| _version_ | 1848825086927175680 |
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| author | Nuramira Fateha, Sukor Rohayu, Jusoh Nur Syahirah, Kamarudin |
| author_facet | Nuramira Fateha, Sukor Rohayu, Jusoh Nur Syahirah, Kamarudin |
| author_sort | Nuramira Fateha, Sukor |
| building | UMP Institutional Repository |
| collection | Online Access |
| description | The current study offers controlled release of niacinamide from fibrous silica (KCC-1) loaded in a face serum formulation. Furthermore, three drug loading methods, namely physical mixing, melting, and solvent evaporation, denoted as (Phy)/Nia-KCC-1, (Mel)/Nia-KCC-1, and (Sol)/Nia-KCC-1, respectively, were implemented, and the percentage loading efficiencies were compared. (Mel)/Nia-KCC-1 demonstrated the highest percentage of drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed a similar pattern, with (Mel)/Nia-KCC-1 recording the highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As the (Mel)/Nia-KCC-1 sample unveiled decent results in transporting the sample drug, the respective sample was then further loaded into the face serum formulation, and the pH stability was observed for 7 days. The pH readings remained constant at pH 4.3 throughout the 7 days, within the acceptance range according to the derma-cosmetic product that states the effective pH should lie between pH 4 and pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 loaded serum fulfills the acceptance criteria for the pH requirement of derma-cosmetic products. |
| first_indexed | 2025-11-15T03:23:20Z |
| format | Conference or Workshop Item |
| id | ump-36797 |
| institution | Universiti Malaysia Pahang |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-15T03:23:20Z |
| publishDate | 2023 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | ump-367972024-04-23T07:48:23Z http://umpir.ump.edu.my/id/eprint/36797/ Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation Nuramira Fateha, Sukor Rohayu, Jusoh Nur Syahirah, Kamarudin QD Chemistry TP Chemical technology The current study offers controlled release of niacinamide from fibrous silica (KCC-1) loaded in a face serum formulation. Furthermore, three drug loading methods, namely physical mixing, melting, and solvent evaporation, denoted as (Phy)/Nia-KCC-1, (Mel)/Nia-KCC-1, and (Sol)/Nia-KCC-1, respectively, were implemented, and the percentage loading efficiencies were compared. (Mel)/Nia-KCC-1 demonstrated the highest percentage of drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed a similar pattern, with (Mel)/Nia-KCC-1 recording the highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As the (Mel)/Nia-KCC-1 sample unveiled decent results in transporting the sample drug, the respective sample was then further loaded into the face serum formulation, and the pH stability was observed for 7 days. The pH readings remained constant at pH 4.3 throughout the 7 days, within the acceptance range according to the derma-cosmetic product that states the effective pH should lie between pH 4 and pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 loaded serum fulfills the acceptance criteria for the pH requirement of derma-cosmetic products. Elsevier Ltd 2023-07 Conference or Workshop Item PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/36797/1/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier%20in%20face%20serum%20formulation.pdf pdf en http://umpir.ump.edu.my/id/eprint/36797/7/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier.pdf pdf en http://umpir.ump.edu.my/id/eprint/36797/8/Controlled%20release%20of%20niacinamide_ABST.pdf Nuramira Fateha, Sukor and Rohayu, Jusoh and Nur Syahirah, Kamarudin (2023) Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation. In: Materials Today: Proceedings. The 6th National Conference for Postgraduate Research (NCON-PGR 2022) , 15 November 2022 , Virtual Conference, Universiti Malaysia Pahang, Malaysia. pp. 1-7.. ISSN 2214-7853 (In Press / Online First) (In Press / Online First) https://doi.org/10.1016/j.matpr.2023.06.379 |
| spellingShingle | QD Chemistry TP Chemical technology Nuramira Fateha, Sukor Rohayu, Jusoh Nur Syahirah, Kamarudin Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title | Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title_full | Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title_fullStr | Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title_full_unstemmed | Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title_short | Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| title_sort | controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation |
| topic | QD Chemistry TP Chemical technology |
| url | http://umpir.ump.edu.my/id/eprint/36797/ http://umpir.ump.edu.my/id/eprint/36797/ http://umpir.ump.edu.my/id/eprint/36797/1/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier%20in%20face%20serum%20formulation.pdf http://umpir.ump.edu.my/id/eprint/36797/7/Controlled%20release%20of%20niacinamide%20from%20fibrous%20silica%20nanocarrier.pdf http://umpir.ump.edu.my/id/eprint/36797/8/Controlled%20release%20of%20niacinamide_ABST.pdf |